dcp2
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  • Official Full Name
  • decapping mRNA 2
  • Background
  • The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5 end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
  • Synonyms
  • DCP2; decapping mRNA 2; NUDT20; m7GpppN-mRNA hydrolase; hDpc; mRNA-decapping enzyme 2; DCP2 decapping enzyme homolog; nudix (nucleoside diphosphate linked moiety X)-type motif 20;
Cat.#:DCP2-2402HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DCP2 Protein, GST-tagged
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Cat.#:DCP2-11861HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DCP2, His-tagged
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Cat.#:DCP2-1570HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human DCP2 protein
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Cat.#:DCP2-1193RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DCP2 Protein, His-tagged
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Cat.#:DCP2-10499ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DCP2
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Cat.#:DCP2-446HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DCP2 cell lysate
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Involved Pathway

DCP2 involved in several pathways and played different roles in them. We selected most pathways DCP2 participated on our site, such as ATF4 activates genes, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCP2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ATF4 activates genes
KCNA3; DCP2; DDIT3; EXOSC8
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
ZFP36L1A; ZFP36L1B; EXOSC8; ZFP36L1; DCP2; MAPKAPK2B
Deadenylation-dependent mRNA decay
DCP2; EIF4EB; EIF4A2; PAIP1; NT5C3B; EIF4G1; EIF4E; C2orf29; TNKS1BP1; EIF4B
Gene Expression
ZNF43; RPP14; ZNF697; ZNF398; RRAGB; ZNF471; GLS2B; FARSB; TSEN54; COX14
KSRP (KHSRP) binds and destabilizes mRNA
EXOSC8; KHSRP; DCP2
Metabolism of proteins
GALNTL5; IGFBP2A; CBX4; NOP56; PROZ; DHPS; PFDN2; FBXW9; ARSJ; ST8SIA2
PERK regulates gene expression
EXOSC8; DCP2
RNA degradation
CNOT2; XRN1; DDX6; CNOT4; EXOSC10; CNOT3; HSPA9; EXOSC6; TOB1; TTC37

Protein Function

DCP2 has several biochemical functions, for example, RNA binding, exoribonuclease activity, producing 5-phosphomonoesters, m7G(5)pppN diphosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCP2 itself. We selected most functions DCP2 had, and list some proteins which have the same functions with DCP2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein YTHDC2; UNC50; PRPF40B; QKIA; SF1; RBM23; WT1; WDHD1; PPIE; EIF4B
Function exoribonuclease activity, producing 5-phosphomonoesters
Related Protein DCP2
Function m7G(5)pppN diphosphatase activity
Related Protein DCPS; NUDT16; DCP2
Function manganese ion binding
Related Protein PPM1N; PPM1M; FAM20C; ENDOU; PCK1; SLC11A2; PPEF2; PIM1; B4GALT7; PAPOLA
Function protein binding
Related Protein DNMT3L; HMGB2; ATG12; MFAP4; MICALL1; DPYSL5; EVC2; EML1; ECHS1; PRNP

Interacting Protein

DCP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCP2.
DCP1A; UPF1; EDC4; Edc4; DCP1B