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DCTN1

  • Official Full Name

    dynactin 1

  • Overview

    This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
  • Synonyms

    DCTN1; dynactin 1; dynactin 1 (p150, Glued (Drosophila) homolog); dynactin subunit 1; p150 glued homolog (Drosophila); 150 kDa dynein-associated polypeptide; dynactin 1 (p150, glued homolog, Drosophila); P135; DP-150; DAP-150;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DCTN1-2410H Recombinant Human DCTN1 Protein, GST-tagged Wheat Germ GST
Human DCTN1-27132TH Recombinant Human DCTN1, His-tagged E.coli His
Human DCTN1-1184H Recombinant Human DCTN1 Protein, His-SUMO-tagged E.coli His/SUMO
Human DCTN1-7043HCL Recombinant Human DCTN1 293 Cell Lysate HEK293 N/A
Human DCTN1-2938HF Recombinant Full Length Human DCTN1 Protein, GST-tagged In Vitro Cell Free System GST 198 amino acids
Rat DCTN1-1800R Recombinant Rat DCTN1 Protein Mammalian Cell His
Rat DCTN1-1458R Recombinant Rat DCTN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DCTN1-1458R-B Recombinant Rat DCTN1 Protein Pre-coupled Magnetic Beads HEK293
Chicken DCTN1-3018C Recombinant Chicken DCTN1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DCTN1 Related Research Area

DCTN1 involved in several pathways and played different roles in them. We selected most pathways DCTN1 participated on our site, such as Adaptive Immune System, Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCTN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemLTN1;CTSO;SRMS;TRIM41;CTSK;CLTA;CTS7;MGC174857;MGC174155
Anchoring of the basal body to the plasma membraneNDE1;CEP164;DYNC1I2;TUBB4B;AKAP9;CETN2;B9D1;CLASP1;CKAP5
Assembly of the primary ciliumB9D2;PCM1;TTC21B;PKD1;TCP1;MAPRE1;TTC30B;FGFR1OP;CEP76
Cell CycleMCM6;GINS1;LIN37;ANAPC2;CDK1;PIANP;ANAPC11;FGFR1OP;LIN52
Cell Cycle, MitoticNUMA1;CETN2;TUBB4B;RBBP4;CKS1B;CDK6;ENSA;NCAPH;KIF2C
Centrosome maturationACTR1A;MAPRE1;ODF2;DYNC1H1;TSGA14;NEDD1;CEP164;CEP72;TUBGCP2
G2/M TransitionOFD1;CCP110;SDCCAG8;MAPRE1B;CEP290;CLASP1;MYBL2;CKAP5;ODF2B
Huntingtons diseaseGRIN1;POLR2B;NDUFA12;COX7C;COX7B2;PLCB1;POLR2J2;NDUFV3;NDUFA13

DCTN1 has several biochemical functions, for example, dynein binding, motor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCTN1 itself. We selected most functions DCTN1 had, and list some proteins which have the same functions with DCTN1. You can find most of the proteins on our site.

Function Related Protein
dynein bindingPAFAH1B1B;ATMIN;DNAAF1;LRRC50;PAFAH1B1A;WDR43;DCTN1;SERPINB1A;DCTN6
motor activityMYO15;MYO5A;MYH9;MYHZ1.1;DYNLT3;MYH1E;DYNC2LI1;MYH15;MYO1C
protein bindingSTOML2;AKAP1;DAP3;SMCO4;PBX4;GJD3;TSKS;FRAG1;MEF2C

DCTN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCTN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCTN1.

Hap1; BBS4; MAPT; Dctn1; Dctn2; Dctn3

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