dctn1
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  • Official Full Name
  • dynactin 1
  • Background
  • This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
  • Synonyms
  • DCTN1; dynactin 1; dynactin 1 (p150, Glued (Drosophila) homolog); dynactin subunit 1; p150 glued homolog (Drosophila); 150 kDa dynein-associated polypeptide; dynactin 1 (p150, glued homolog, Drosophila); P135; DP-150; DAP-150
Cat.#:DCTN1-1184HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DCTN1 Protein, His-SUMO-tagged
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Cat.#:DCTN1-2410HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DCTN1 Protein, GST-tagged
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Cat.#:DCTN1-27132THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DCTN1, His-tagged
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Cat.#:DCTN1-1800RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DCTN1 Protein
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Cat.#:DCTN1-3018CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DCTN1
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Cat.#:DCTN1-7043HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DCTN1 293 Cell Lysate
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Involved Pathway

DCTN1 involved in several pathways and played different roles in them. We selected most pathways DCTN1 participated on our site, such as Adaptive Immune System, Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCTN1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
HLA-DQB2; HBEGF; CLEC2D; AP2S1; UBE2V2; RBCK1; AP2B1; CTLA4; KLRB1A; RAPGEF3
Anchoring of the basal body to the plasma membrane
CEP290; CEP72; MAPRE1B; NEDD1; DCTN1A; TUBG1; CCP110; CEP152; ACTR1A; TCTN3
Assembly of the primary cilium
CSNK1E; IFT80; TTC26; CLASP1A; BBS10; MAPRE1; CCP110; EXOC6; MKS1; ODF2
Cell Cycle
CDCA5; HUS1; DCTN3; DHFR; ANAPC2; KIF2C; SMAD2; TGFB3; POT1A; USO1
Cell Cycle, Mitotic
CSNK2A1; RANGAP1B; MYBL2; GMNN; NEK9; DYRK1A; DCTN1; TCTN2; PMF1; NCAPG2
Centrosome maturation
TUBG1; ACTR1A; PCM1; CEP152; PLK4; MAPRE1B; OFD1; TUBGCP4; SDCCAG8; CEP57
G2/M Transition
CCP110; ODF2B; MAPRE1A; DCTN1A; NEDD1; LIN9; NINL; CP110; TUBG1; MAPRE1B
Huntingtons disease
PLCB3; NDUFS8; ATP5F1; UQCRB; ATP5H; HIP1; NDUFS7; POLR2I; NDUFA8; COX7B

Protein Function

DCTN1 has several biochemical functions, for example, dynein binding, motor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCTN1 itself. We selected most functions DCTN1 had, and list some proteins which have the same functions with DCTN1. You can find most of the proteins on our site.
Function
Related Protein
Function dynein binding
Related Protein SNCA; SMC3; KATNA1; DCTN6; BICD1; SERPINB1A; WDR43; PAFAH1B1A; DCTN1; PAFAH1B1
Function motor activity
Related Protein DYNC1I1; DYNC2LI1; DYNLRB1; CGNL1; MYL6; MYHC4; KIF3C; MYHZ1.2; MYO1EB; MYH8
Function protein binding
Related Protein MEIS1; SH3GL2; IL23; BBS12; MACF1; INHA; TET2; NECAB2; MMP20; FEM1B

Interacting Protein

DCTN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCTN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCTN1.
Hap1; BBS4; MAPT; Dctn1; Dctn2; Dctn3