ddc
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  • Official Full Name
  • dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • Background
  • The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine,;L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic;L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that;leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding;different isoforms have been identified for this gene.
  • Synonyms
  • DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase); aromatic-L-amino-acid decarboxylase; AADC
Cat.#:DDC-223HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDC Protein, MYC/DDK-tagged
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Cat.#:DDC-2433HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDC Protein, GST-tagged
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Cat.#:DDC-491HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDC Protein, His-tagged
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Cat.#:Ddc-2510MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dopa Decarboxylase, His-tagged
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Cat.#:DDC-26888THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDC, His-tagged
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Cat.#:DDC-28085THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDC
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Cat.#:DDC-284HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DDC, His tagged
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Cat.#:DDC-848HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDC, T7-tagged
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Cat.#:DDC-915MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse DDC Protein, His-tagged
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Cat.#:Ddc-3638RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Ddc, His-tagged
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Cat.#:DDC-12525ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DDC
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Cat.#:DDC-141HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Dopa Decarboxylase, His-tagged
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Cat.#:DDC-724HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DDC cell lysate
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Cat.#:DDC-513MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse DDC cell lysate
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Involved Pathway

DDC involved in several pathways and played different roles in them. We selected most pathways DDC participated on our site, such as Alcoholism, Amine-derived hormones, Amphetamine addiction, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
HIST1H3A; HIST2H2BE; NTRK2; CREB3L3; GRIN2A; HIST1H3D; ADORA2B; H2AFB1; GM14479; HIST1H4J
Amine-derived hormones
DDC; TPH2; DIO2; CGA; DBH
Amphetamine addiction
GRIN2B; PPP3CB; GRIN3B; MAOB; GRIA1; DRD1; ATF4; DRD1A; GRIN2C; GNAS
Biogenic Amine Synthesis
CHAT; COMT; DBH; DDC
Catecholamine biosynthesis
DBH; MOXD2; DDC
Cocaine addiction
DLG4; GNAI2; PRKACA; CREB3L1; SLC18A1; GRIN2D; PRKACB; GRIA2; GRIN3A; PDYN
Dopamine metabolism
COMT; DDC; NQO1
Dopaminergic synapse
KIF5C; PLCB3; DRD1A; CALML5; AKT1; PPP2R5B; CLOCK; PPP2R3A; GRIA3; PRKACG

Protein Function

DDC has several biochemical functions, for example, L-dopa decarboxylase activity, amino acid binding, aromatic-L-amino-acid decarboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDC itself. We selected most functions DDC had, and list some proteins which have the same functions with DDC. You can find most of the proteins on our site.
Function
Related Protein
Function L-dopa decarboxylase activity
Related Protein DDC
Function amino acid binding
Related Protein AGXT; DDC; GCHFR; DDAH2; TH; TPH1A; PAH; TPH1; SHMT2; GOT2
Function aromatic-L-amino-acid decarboxylase activity
Related Protein DDC
Function enzyme binding
Related Protein PIAS1; ITGB3; TOP2A; EIF4E; TARBP2; RPA3; GOLPH3; PARK7; CAV1; CTNNB1
Function protein binding
Related Protein CDKN1C; RIPPLY1; FGD5; ZSCAN10; ICK; RMI1; EIF2B1; PTPN11; NLRP12; DROSHA
Function protein domain specific binding
Related Protein PKD1; FOXA3; STXBP1; MED12; SKI; TFDP2; CALM2; HIST1H4E; VRK2; YWHAE
Function pyridoxal phosphate binding
Related Protein SPTLC2; SPTLC2A; GPT2L; SDS; SGPL1; PHYKPL; SRR; MOSC2; LOC650128; NFS1

Interacting Protein

DDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDC here. Most of them are supplied by our site. Hope this information will be useful for your research of DDC.
AR; Ar; ATF6; RELA

DDC Related Articles

Pi, LY; Robinson, PM; et al. Connective Tissue Growth Factor and Integrin alpha v beta 6: A New Pair of Regulators Critical for Ductular Reaction and Biliary Fibrosis in Mice. HEPATOLOGY 61:678-691(2015).
Yoshida, S; Ikenaga, N; et al. Extrahepatic Platelet-Derived Growth Factor-beta, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice. GASTROENTEROLOGY 147:1378-1392(2014).