ddit4
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  • Official Full Name
  • DNA-damage-inducible transcript 4
  • Background
  • Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death.
  • Synonyms
  • DDIT4; DNA-damage-inducible transcript 4; DNA damage-inducible transcript 4 protein; Dig2; FLJ20500; HIF 1 responsive RTP801; REDD 1; REDD1; RTP801; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801 (RTP801); protein regulated in development and DN
Cat.#:DDIT4-214HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDIT4 Protein, MYC/DDK-tagged
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Cat.#:DDIT4-2445HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDIT4 Protein, GST-tagged
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Cat.#:DDIT4-28311THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDIT4
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Cat.#:DDIT4-3433HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDIT4 protein, His-tagged
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Cat.#:REDD1-2245HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human REDD1 protein
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Cat.#:DDIT4-1811RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DDIT4 Protein
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Cat.#:DDIT4-1207RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DDIT4 Protein, His-tagged
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Cat.#:DDIT4-10459ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DDIT4
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Cat.#:DDIT4-7026HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DDIT4 293 Cell Lysate
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Involved Pathway

DDIT4 involved in several pathways and played different roles in them. We selected most pathways DDIT4 participated on our site, such as mTOR signaling pathway, PIK-Akt signaling pathway, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDIT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mTOR signaling pathway
PRKAA2; STK11; MTOR; CAB39L; PIK3R3A; RPS6KA3B; RPS6KA2; TSC1A; PIK3R1; PTEN
PIK-Akt signaling pathway
VTN; IL3RA; PPP2CB; ITGB6; TP53; CRTC2; GNB2; RPS6; IFNA21; PRL
MicroRNAs in cancer
DNMT3B; TRP63; CDCA5; HDAC1; STMN1; PLCG2; RAF1; ERBB3; CCND2; IRS1

Protein Function

DDIT4 has several biochemical functions, for example, 14-3-3 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDIT4 itself. We selected most functions DDIT4 had, and list some proteins which have the same functions with DDIT4. You can find most of the proteins on our site.
Function
Related Protein
Function 14-3-3 protein binding
Related Protein ARRB2; PRKCZ; ZFP36; HDAC7; RPTOR; DDIT4; TSC2; KCNH1; SRPK2; IRS2

Interacting Protein

DDIT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDIT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDIT4.
DDB1; BTRC; PDPK1; HSPA4; RIF1; q8czf9_yerpe; UBC; PLCG1; YWHAZ; CUL4A