DDIT4
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Official Full Name
DNA-damage-inducible transcript 4
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Overview
Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. -
Synonyms
DDIT4; DNA-damage-inducible transcript 4; DNA damage-inducible transcript 4 protein; Dig2; FLJ20500; HIF 1 responsive RTP801; REDD 1; REDD1; RTP801; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801 (RTP801); protein regulated in development and DN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
DDIT4 involved in several pathways and played different roles in them. We selected most pathways DDIT4 participated on our site, such as mTOR signaling pathway, PIK-Akt signaling pathway, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDIT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mTOR signaling pathway | ULK3;MTOR;PRKCA;PTEN;PIK3R1;TSC1A;RRAGD;PRKAA2;EIF4E2 |
| PIK-Akt signaling pathway | MAP2K1;FOXO3;PRKAA1;IFNA1;Itga10&Itgb1;PRLR;IL2RA;PDGFB;GRB2 |
| MicroRNAs in cancer | CCND1;RECK;CD44;TRIM71;EP300;TGFB2;HOXD10;SLC45A3;THBS1 |
DDIT4 has several biochemical functions, for example, 14-3-3 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDIT4 itself. We selected most functions DDIT4 had, and list some proteins which have the same functions with DDIT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 14-3-3 protein binding | PPP1R12A;DDIT4;HDAC7A;RPTOR;KCNH1;YWHAQ;KIF13B;AKT1;IRS2 |
DDIT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDIT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDIT4.
DDB1; BTRC; PDPK1; HSPA4; RIF1; q8czf9_yerpe; UBC; PLCG1; YWHAZ; CUL4A
- Q&As
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