ddost
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  • Official Full Name
  • dolichyl-diphosphooligosaccharide--protein glycosyltransferase
  • Background
  • This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.
  • Synonyms
  • DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; KIAA0115; MGC2191; OK/SW-cl.45; OST; OST48; WBP1; AGE R1; DDOST 48 kDa subunit; Dolichyl-diphosphooligosaccharide-protein glycosyltransferase; EC 2.4.1.119; Oligosaccharyl transferase 48 kDa subunit; RP23-25C1.4; wu:fa11d01; zgc:66068; zgc:77478; advanced glycation endproduct receptor 1; oligosaccharyltransferase 48 kDa subunit; dolichyl-diphosphooligosaccharide-protein glycotransferase; AGER1; OKSWcl45
Cat.#:DDOST-211HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDOST Protein, MYC/DDK-tagged
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Cat.#:DDOST-2451HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDOST Protein, GST-tagged
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Cat.#:DDOST-1127HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDOST, None tagged
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Cat.#:DDOST-11884HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDOST, His-tagged
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Cat.#:Ddost-1653MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ddost protein, His-tagged
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Cat.#:DDOST-4392MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DDOST Protein
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Cat.#:DDOST-1814RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DDOST Protein
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Cat.#:DDOST-4040CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DDOST
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Cat.#:DDOST-12319ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DDOST
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Cat.#:DDOST-7024HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DDOST 293 Cell Lysate
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Involved Pathway

DDOST involved in several pathways and played different roles in them. We selected most pathways DDOST participated on our site, such as AGE/RAGE pathway, Advanced glycosylation endproduct receptor signaling, Asparagine N-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDOST were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AGE/RAGE pathway
MAPK14; LGALS3; CHUK; ATF2; EGFR; DDOST; JUN; DIAPH1; TIRAP; AGER
Advanced glycosylation endproduct receptor signaling
S100B; SAA1; DDOST; APPA; AGER; LGALS3; ALCAMB; S100A12; APPB
Asparagine N-linked glycosylation
SEC22C; SEC23A; OS9; NAPAA; SEC16B; DAD1; CNIH; ST3GAL3A; TRAPPC3; TRAPPC9
Gene Expression
ZNF254; TSEN54; AIMP1; SSRP1; ZNF625; ZNF483; NR1D2; RPP14; ZNF443; EFCAB11
Immune System
GRAP2B; CTSLL; KIF4A; CLEC6A; RNF135; GZMM; CASPBL; TREML2; XAF1; SIGLEC8
Innate Immune System
CNPY3; BTR22; NLRP4C; PPAPDC1A; ABI1; HERC5; BAIAP2; CASP2; TRIM56; DEFB116
Metabolic pathways
GCNT1; SPTLC3; ST3GAL3B; PLCD3A; COX8C; LDHAL6B; CYP2P10; ACACA; AMPD2; UGDH
Metabolism of proteins
ALG2; SPON1B; DPH3; ARSD; CDX2; ST6GALNAC2; ARSF; CNIH3; SERP1; DHPS

Protein Function

DDOST has several biochemical functions, for example, contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity, contributes_to oligosaccharyl transferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDOST itself. We selected most functions DDOST had, and list some proteins which have the same functions with DDOST. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity
Related Protein OSTC; STT3A; DDOST; TUSC3; RPN2; DAD1; RPN1
Function contributes_to oligosaccharyl transferase activity
Related Protein DDOST; DAD1
Function protein binding
Related Protein MCCC2; MICA; MSH6; C1orf38; MLF1IP; LIMD2; CCL11; HNRNPH1; DCP2; Car8

Interacting Protein

DDOST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDOST here. Most of them are supplied by our site. Hope this information will be useful for your research of DDOST.
TMEM173; SEC27; copa_schpo; 7242199; PGRMC1; SAP18; RFXANK; PTP4A3; TNFRSF1A; TNFRSF1B; MCC; HLA-B; MAGEA6; BRCC3; COP1; EIF6; ARF6; SMYD3; TMBIM4