def6
Share
  • Official Full Name
  • differentially expressed in FDCP 6 homolog (mouse)
  • Background
  • DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly;expressed in B and T cells (Gupta et al., 2003 (PubMed 12923183)).
  • Synonyms
  • DEF6; differentially expressed in FDCP 6 homolog (mouse); differentially expressed in FDCP (mouse homolog) 6; differentially expressed in FDCP 6 homolog; IBP; SLAT; SWAP 70 like adaptor protein of T cells; SWAP70L; DEF-6; IRF4-binding protein; SWAP-70-lik
Cat.#:DEF6-2516HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DEF6 Protein, GST-tagged
+Inquiry
Cat.#:DEF6-460HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DEF6 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:DEF6-11923HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DEF6, GST-tagged
+Inquiry
Cat.#:DEF6-491HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DEF6 Protein, His-tagged
+Inquiry
Cat.#:DEF6-4442MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DEF6 Protein
+Inquiry
Cat.#:DEF6-6993HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DEF6 293 Cell Lysate
+Inquiry

Involved Pathway

DEF6 involved in several pathways and played different roles in them. We selected most pathways DEF6 participated on our site, such as Regulation of RAC1 activity, Regulation of RhoA activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEF6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Regulation of RAC1 activity
CHN2; RALBP1; RAP1GDS1; ARHGAP17; ARHGAP1; EPS8; SPATA13; DEF6; ARHGEF25; CHN1
Regulation of RhoA activity
DLC1; ARHGEF18; DEF6; AKAP13; ARHGEF25; ABR; ARHGEF10L; ARHGAP9; ARAP1; ARHGEF28

Protein Function

DEF6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DEF6 itself. We selected most functions DEF6 had, and list some proteins which have the same functions with DEF6. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein PAGE2; PALLD; GOPC; NME1; MCM2; OIP5; RYR2; RAB34; GRHL3; ZNF385C

Interacting Protein

DEF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEF6.
PTK2; PLSCR1; TCF4; CDC42EP1; HOMEZ; PBXIP1; EIF4ENIF1