dgkd
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  • Official Full Name
  • diacylglycerol kinase, delta 130kDa
  • Background
  • This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.
  • Synonyms
  • DGKD; diacylglycerol kinase, delta 130kDa; diacylglycerol kinase, delta (130kD); diacylglycerol kinase delta; DGKdelta; diglyceride kinase; KIAA0145; DGK-delta; DAG kinase delta; diglyceride kinase delta; dgkd-2; FLJ26930
Cat.#:DGKD-26772THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DGKD, His-tagged
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Involved Pathway

DGKD involved in several pathways and played different roles in them. We selected most pathways DGKD participated on our site, such as Glycerolipid metabolism, Glycerophospholipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKD were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerolipid metabolism
LCLAT1; DGAT2; ALDH2.2; DGKG; PNPLA3; CELL; DGAT1; MOGAT3; ALDH1B1; Akr1b3
Glycerophospholipid metabolism
PEMT; PLA2G4AA; PLA2G2A; PLD1; LPCAT4; CDS2; DGKAA; LPIN2; GPAT2; LPIN1
Metabolic pathways
GALNT1; IDH3B; HADHB; PIGS; CDS1; NADK2; IDI2; MAN1C1; C1GALT1B; DAO.1
Phosphatidylinositol signaling system
INPP5KA; PIK3R5; PI4KB; PIK3R3B; PIKFYVE; ITPK1A; PTENB; PLCB1; PIP4K2AA; INPP5E
Phospholipase D signaling pathway
DNM3; RRAS2; PPAP2B; AVPR2; PPAP2C; CYTH3; PLD1; GRM2; GRM3; DGKZ
Choline metabolism in cancer
PDGFRA; FOS; PIP5K1C; AKT2; PLD1; PIP5K1B; GRB2; SOS1; PRKCA; RPS6KB2

Protein Function

DGKD has several biochemical functions, for example, ATP binding, diacylglycerol kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKD itself. We selected most functions DGKD had, and list some proteins which have the same functions with DGKD. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein BMP2K; MAP2K1; ABCB6; RPS6KA3A; HSP90AB1; AARSD1; PPP1CA; PDK4; KITA; RARS
Function diacylglycerol kinase activity
Related Protein TAE1; DGKG; DGKB; DGKE; DGKAA; DGKD; DGKA; AGK; DGKZ; DGKQ
Function metal ion binding
Related Protein TP73; PHF23B; DMRT3A; ZFY1; DEAF1; RNF149; GALNT7; SH3RF3; S100T; ATP1A1A.3

Interacting Protein

DGKD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKD here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKD.
DYSF; MYH13; HAX1; q74yg8_yerpe; TNFRSF14; IGSF21; Srek1

DGKD Related Articles

Toriumi, K; Horikoshi, Y; et al. Carbon tetrachloride-induced hepatic injury through formation of oxidized diacylglycerol and activation of the PKC/NF-kappa B pathway. LABORATORY INVESTIGATION 93:218-229(2013).
Carracedo, S; Braun, U; et al. Expression pattern of protein kinase C delta during mouse embryogenesis. BMC DEVELOPMENTAL BIOLOGY 13:-(2013).