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DHPS

  • Official Full Name

    deoxyhypusine synthase

  • Overview

    This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms

    DHPS; deoxyhypusine synthase; MIG13; migration inducing gene 13; DHS; DHYS_HUMAN; DS; migration-inducing gene 13;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DHPS-11970H Recombinant Human DHPS, GST-tagged E.coli GST 1-369a.a.
Human DHPS-2592H Recombinant Human DHPS Protein, GST-tagged Wheat Germ GST
Human DHPS-568H Recombinant Human Deoxyhypusine Synthase, His-tagged E.coli His
Human DHPS-26684TH Recombinant Human DHPS, His-tagged E.coli His 369 amino acids
Human DHPS-26685TH Recombinant Human DHPS, His-tagged E.coli His
Human DHPS-6942HCL Recombinant Human DHPS 293 Cell Lysate HEK293 N/A
Human DHPS-2533HF Recombinant Full Length Human DHPS Protein, GST-tagged In Vitro Cell Free System GST 369 amino acids
Human DHPS-4650H Recombinant Human DHPS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DHPS-1963H Recombinant Human DHPS Protein (Met1-Asp369), N-His tagged E.coli N-His Met1-Asp369
Human DHPS-5177H Recombinant Human DHPS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DHPS-1962H Recombinant Human DHPS Protein (Met1-Asp369), C-His tagged E.coli C-His Met1-Asp369
Mouse DHPS-4559M Recombinant Mouse DHPS Protein Mammalian Cell His
Mouse DHPS-2356M Recombinant Mouse DHPS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DHPS-2356M-B Recombinant Mouse DHPS Protein Pre-coupled Magnetic Beads HEK293
Mouse Dhps-2547M Recombinant Mouse Dhps Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat DHPS-1860R Recombinant Rat DHPS Protein Mammalian Cell His
Rat DHPS-1518R-B Recombinant Rat DHPS Protein Pre-coupled Magnetic Beads HEK293
Rat DHPS-1518R Recombinant Rat DHPS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DHPS-1253R Recombinant Rhesus monkey DHPS Protein, His-tagged Mammalian Cell His
Rhesus Macaque DHPS-1078R Recombinant Rhesus Macaque DHPS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DHPS-1078R-B Recombinant Rhesus Macaque DHPS Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DHPS-12425Z Recombinant Zebrafish DHPS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DHPS Related Articles

DHPS involved in several pathways and played different roles in them. We selected most pathways DHPS participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHPS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gamma carboxylation, hypusine formation and arylsulfatase activationDPH2;ARSK;ARSE;DNAJC24;EEF2;ARSD;DOHH;F9B;ARSF
Hypusine synthesis from eIF5A-lysineDHPS;EIF5A;DOHH;EIF5A2
Metabolism of proteinsPPP6R3;MUC13;MAGT1;HSCB;MAN1B1;TRAPPC2;COX17;EEF1G;BET1
Post-translational protein modificationMAN1B1;NSMCE2;GALNTL2;MAGT1;SEC22A;TRAPPC6B;TRAPPC2L;C8orf84;SEC22C
hypusine biosynthesisDHPS;DOHH

DHPS has several biochemical functions, for example, deoxyhypusine synthase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHPS itself. We selected most functions DHPS had, and list some proteins which have the same functions with DHPS. You can find most of the proteins on our site.

Function Related Protein
deoxyhypusine synthase activity
protein bindingRYR2;ZFP36L1;RANBP6;TMEM231;ZNF643;TMEM147;SSR1;CBX3;CCDC108

DHPS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHPS here. Most of them are supplied by our site. Hope this information will be useful for your research of DHPS.

MAPK3; RPL9P7; EIF5A2; NUDT18; NIF3L1; RAB27B

Liang, X; Wang, ZH; et al. A proof-of-concept receptor-based assay for sulfonamides. ANALYTICAL BIOCHEMISTRY 438:110-116(2013).
Kyan, H; Taira, M; et al. Isolation and Characterization of Toxoplasma gondii Genotypes from Goats at an Abattoir in Okinawa. JAPANESE JOURNAL OF INFECTIOUS DISEASES 65:167-170(2012).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any resistance mechanisms against sulfonamides targeting DHPS? 04/30/2021

Yes, bacterial resistance to sulfonamides can arise due to mutations in DHPS that reduce the drug's binding affinity.

Can DHPS mutations affect the effectiveness of sulfonamides in treating bacterial infections? 06/26/2020

Yes, mutations in DHPS can lead to reduced effectiveness of sulfonamides, contributing to antibiotic resistance.

Are there any other clinical implications of DHPS beyond antibiotic treatment? 03/24/2020

DHPS mutations have been associated with resistance to sulfadoxine-pyrimethamine, a drug used to prevent and treat malaria.

In what clinical conditions are sulfonamides commonly used? 05/25/2018

Sulfonamides are used to treat urinary tract infections, respiratory tract infections, and other bacterial infections.

Can DHPS be a target for drug development beyond antibiotics? 05/16/2016

DHPS has potential as a target for developing new antiparasitic drugs due to its role in folate biosynthesis in parasites such as Plasmodium.

Customer Reviews (3)

Write a review
Reviews
12/26/2020

    Their expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.

    02/14/2019

      Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.

      02/05/2019

        The DHPS protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.

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