DHPS
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Official Full Name
deoxyhypusine synthase
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Overview
This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
DHPS; deoxyhypusine synthase; MIG13; migration inducing gene 13; DHS; DHYS_HUMAN; DS; migration-inducing gene 13;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- DHPS Related Articles
DHPS involved in several pathways and played different roles in them. We selected most pathways DHPS participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHPS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Gamma carboxylation, hypusine formation and arylsulfatase activation | DPH2;ARSK;ARSE;DNAJC24;EEF2;ARSD;DOHH;F9B;ARSF |
Hypusine synthesis from eIF5A-lysine | DHPS;EIF5A;DOHH;EIF5A2 |
Metabolism of proteins | PPP6R3;MUC13;MAGT1;HSCB;MAN1B1;TRAPPC2;COX17;EEF1G;BET1 |
Post-translational protein modification | MAN1B1;NSMCE2;GALNTL2;MAGT1;SEC22A;TRAPPC6B;TRAPPC2L;C8orf84;SEC22C |
hypusine biosynthesis | DHPS;DOHH |
DHPS has several biochemical functions, for example, deoxyhypusine synthase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHPS itself. We selected most functions DHPS had, and list some proteins which have the same functions with DHPS. You can find most of the proteins on our site.
Function | Related Protein |
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deoxyhypusine synthase activity | |
protein binding | RYR2;ZFP36L1;RANBP6;TMEM231;ZNF643;TMEM147;SSR1;CBX3;CCDC108 |
DHPS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHPS here. Most of them are supplied by our site. Hope this information will be useful for your research of DHPS.
MAPK3; RPL9P7; EIF5A2; NUDT18; NIF3L1; RAB27B
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, bacterial resistance to sulfonamides can arise due to mutations in DHPS that reduce the drug's binding affinity.
Yes, mutations in DHPS can lead to reduced effectiveness of sulfonamides, contributing to antibiotic resistance.
DHPS mutations have been associated with resistance to sulfadoxine-pyrimethamine, a drug used to prevent and treat malaria.
Sulfonamides are used to treat urinary tract infections, respiratory tract infections, and other bacterial infections.
DHPS has potential as a target for developing new antiparasitic drugs due to its role in folate biosynthesis in parasites such as Plasmodium.
Customer Reviews (3)
Write a reviewTheir expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.
Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.
The DHPS protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.
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