dhrs9
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  • Official Full Name
  • dehydrogenase/reductase (SDR family) member 9
  • Background
  • 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH.
  • Synonyms
  • DHRS9; dehydrogenase/reductase (SDR family) member 9; dehydrogenase/reductase SDR family member 9; 3 alpha hydroxysteroid dehydrogenase; 3alpha HSD; NADP dependent retinol dehydrogenase/reductase; RDH15; RDHL; retinol dehydrogenase homolog; RETSDR8; SDR9C4; short chain dehydrogenase/reductase family 9C; member 4; 3-@alpha-HSD; 3-@alpha-hydroxysteroid dehydrogenase; 3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; DHRS9_HUMAN; NADP-dependent retinol dehydrogenase/reductase; RDH-E2; RDHE2; RDHTBE; Retinol dehydrogenase, tracheobronchiol epithelail cell-specific; SDR family, member 9; short chain dehydrogenase/reductase family 9; short chain dehydrogenase/reductase family 9C, member 4; Short chain dehydrogenase/reductase retSDR8; Short-chain dehydrogenase/reductase retSDR8; OTTHUMP00000163043; OTTHUMP00000204923; OTTHUMP00000204925; OTTHUMP00000204926; OTTHUMP00000205057; 3ALPHA-HSD
Cat.#:DHRS9-2603HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DHRS9 Protein, GST-tagged
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Cat.#:DHRS9-1561HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Dehydrogenase/Reductase (SDR Family) Member 9, His-tagged
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Cat.#:DHRS9-270HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DHRS9, His-tagged
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Cat.#:DHRS9-1863RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DHRS9 Protein
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Cat.#:DHRS9-10010ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DHRS9
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Cat.#:DHRS9-6934HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DHRS9 293 Cell Lysate
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Involved Pathway

DHRS9 involved in several pathways and played different roles in them. We selected most pathways DHRS9 participated on our site, such as Metabolic pathways, RA biosynthesis pathway, Retinol metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHRS9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolic pathways
SPTLC3; GPT; ATP6AP1; URAD; CBR3; MGAT1A; KLF15; PLD1; P4HA1; PLCD3A
RA biosynthesis pathway
RDH13; RDH10; DHRS9; ADH8A; RDH7; DHRS4; ADH8B; RDH14; SDR16C5; CRABP1A
Retinol metabolism
AOX4; RDH8A; CYP3A25; RDH10B; UGT2A2; UGT5G1; DHRS4; UGT1A1; BCO1; AOX2P
Signal Transduction
JUPA; USP9; SOX6; AKR1C6; ARHGAP17A; CSHL1; DISP2; NOXA1; PNOCB; CGNB
Signaling by Retinoic Acid
DHRS4; SDR16C5; RDH7; PDK3; RARGA; PDK2; CRABP2; ALDH8A1; PDK4; PDK3B
The canonical retinoid cycle in rods (twilight vision)
MYO7A; RDH12; RLBP1B; IRBP; RLBP1A; RPE65A; RLBP1; RPE65B; DHRS9; MYO7AA
Visual phototransduction
RGS9BP; DHRS9; APOA4B.2; IRBP; ABCA4A; RLN1; CLPS; RLBP1B; NMT1B; BCO2L
retinol biosynthesis
DHRS9; CES5A; RBP5; DHRS4

Protein Function

DHRS9 has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity, racemase and epimerase activity, retinol dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHRS9 itself. We selected most functions DHRS9 had, and list some proteins which have the same functions with DHRS9. You can find most of the proteins on our site.
Function
Related Protein
Function alcohol dehydrogenase (NAD) activity
Related Protein ADH1; ADH1A; ADH6; ADH8A; ADH7; ADH1C; ADH4; DHRS9; ADH5; ADH8B
Function racemase and epimerase activity
Related Protein DHRS9
Function retinol dehydrogenase activity
Related Protein ADH7; SDR16C5; DHRS7C; SDR9C7; BMP2; AKR1C3; HSD17B6; DHRS3; RDH11; RDH10
Function testosterone dehydrogenase (NAD+) activity
Related Protein DHRS9; H2-KE6; HSD17B8; AKR1C3; HSD17B1; HSD17B2; HSD17B6

DHRS9 Related Articles

Zubair, N; Kooperberg, C; et al. Genetic Variation Predicts Serum Lycopene Concentrations in a Multiethnic Population of Postmenopausal Women. JOURNAL OF NUTRITION 145:187-192(2015).
Lord, DM; Baran, AU; et al. BdcA, a Protein Important for Escherichia coli Biofilm Dispersal, Is a Short-Chain Dehydrogenase/Reductase that Binds Specifically to NADPH. PLOS ONE 9:-(2014).