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DIAPH1

Official Full Name

diaphanous homolog 1 (Drosophila)
Overview

This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms

DIAPH1; diaphanous homolog 1 (Drosophila); DFNA1, diaphanous (Drosophila, homolog) 1; protein diaphanous homolog 1; hDIA1; LFHL1; FLJ25265; Deafness autosomal dominant 1; deafness, autosomal dominant 1; DFNA1; DIAP1; DIAP1_HUMAN; diaphanous homolog 1; Diaphanous protein homolog 1; Diaphanous related formin 1; Diaphanous-related formin-1; DRF1; low frequency hearing loss 1; p140DIA; OTTHUMP00000195047; OTTHUMP00000195048; OTTHUMP00000195049; OTTHUMP00000224777; diaphanous-related formin 1; DIA1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

Flag
GST
His
His (Fc)
Avi
His|GST
Myc
DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DIAPH1-2621H	Recombinant Human DIAPH1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DIAPH1-6925HCL	Recombinant Human DIAPH1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	DIAPH1-720HFL	Recombinant Full Length Human DIAPH1 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	DIAPH1-761H	Recombinant Human DIAPH1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	DIAPH1-1965H	Recombinant Human DIAPH1 Protein (Asp389-Pro583), N-His tagged	E.coli	N-His	Asp389-Pro583	Inquiry
Human	DIAPH1-1649H	Recombinant Human DIAPH1 protein, His & GST-tagged	E.coli	His/GST	Asp389~Pro583 (Accession # O60610)	Inquiry
Human	DIAPH1-761H-B	Recombinant Human DIAPH1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	DIAPH1-852H	Recombinant Human DIAPH1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	DIAPH1-4912H	Recombinant Human DIAPH1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Diaph1-2564M	Recombinant Mouse Diaph1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Chicken	DIAPH1-5784C	Recombinant Chicken DIAPH1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
DIAPH1 Related Articles

DIAPH1 involved in several pathways and played different roles in them. We selected most pathways DIAPH1 participated on our site, such as AGE/RAGE pathway, Focal adhesion, G13 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIAPH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
AGE/RAGE pathway	DIAPH1;JUN;LGALS3;TIRAP;MAPK14;MMP13;DDOST;EGFR;CHUK
Focal adhesion	ITGB1B.2;SHC1;PIK3R2;IBSP;CAPN2;PIK3R3;PTK2;ITGB1;Pdgfa&Pdgfb
G13 Signaling Pathway	SH3RF1;RHPN2;ARHGEF1A;MYL1;CIT;GNA13;CFL2;TNK2;RTKN
RHO GTPase Effectors	RHOAE;SPC24;CIT;SKA1;PRC1;EVL;NOXO1A;ABI1A;KTN1
RHO GTPases Activate Formins	NDEL1B;RANGAP1B;SKA1;RHOAE;DIAPH1;SKA2;FMNL2;DSN1;NSL1
Regulation of actin cytoskeleton	FGF12A;PDGFB;ACTN2;F2;Itga10&Itgb1;FGF6B;ITGA9;RAC3;PAK7
RhoA signaling pathway	MKL1;CYR61;ACTA1;DIAPH1
Shigellosis	U2AF1L4;ROCK2;ACTB;SRC;HCLS1;MAPK12;MAD2L2;UBE2D2;CDC42

DIAPH1 has several biochemical functions, for example, Rho GTPase binding, actin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DIAPH1 itself. We selected most functions DIAPH1 had, and list some proteins which have the same functions with DIAPH1. You can find most of the proteins on our site.

Function	Related Protein
Rho GTPase binding	ROCK2;FMNL2;RHOH;DOCK11;DAAM1B;DIAP3;CSDA;AKAP13;DAPK3
actin binding	ADD3;CFL2L;VILL;SPTAN1;SCINLB;ALDOA;PARVA;ACTR2A;EPB41L3A
identical protein binding	TRAF2;DAPK1;DYNLT1F;NCAM1;INHBA;MDM2;PSME3;PLDN;SSNA1
ion channel binding	DIAPH1;PACS2;PRKCSH;AKAP9;FKBP1A;ASPH;CDH5;FXYD1;SCN5A
poly(A) RNA binding	SUGP1;SRSF3;SNW1;RPL35;LBR;EIF4H;HNRNPA2B1;LSM6;PPP1R2P9
profilin binding	DIAP1;CTTN;EVL;FMNL1;PCLO;CYFIP1;DIAPH1;RHOQ;WIPF1
protein binding	STRA13;MRPL44;HTR6;TICAM2;CTCF;GATA3;RHOXF2;PROP1;R3HDM2
receptor binding	CSNK2B;SLC9A3R1;LAMA3;CD160;CADM1;PKD2;FGF18A;PTK2B;HFE

DIAPH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIAPH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DIAPH1.

RHOA; AGER; PPM1F; PKD2; ORF; RHOD; RHOC; RHOB; RHOF; GAS7; WBP4

Chang, ALS; Atzmon, G; et al. Identification of Genes Promoting Skin Youthfulness by Genome-Wide Association Study. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:651-657(2014).

Schoen, CJ; Burmeister, M; et al. Diaphanous homolog 3 (Diap3) Overexpression Causes Progressive Hearing Loss and Inner Hair Cell Defects in a Transgenic Mouse Model of Human Deafness. PLOS ONE 8:-(2013).