dkc1
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  • Official Full Name
  • dyskeratosis congenita 1, dyskerin
  • Background
  • This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
  • Synonyms
  • DKC1; dyskeratosis congenita 1, dyskerin; DKC; CBF5; DKCX; NAP57; NOLA4; XAP101; H/ACA ribonucleoprotein complex subunit 4; CBF5 homolog; snoRNP protein DKC1; nucleolar protein NAP57; nucleolar protein family A member 4; nopp140-associated protein of 57 kDa;
Cat.#:DKC1-685HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DKC1 Protein, His-tagged
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Cat.#:Dkc1-686MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dkc1 Protein, His-tagged
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Cat.#:Dkc1-687RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Dkc1 Protein, His-tagged
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Cat.#:DKC1-261HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DKC1 protein, GST-tagged
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Cat.#:DKC1-1875RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DKC1 Protein
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Cat.#:DKC1-1272RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DKC1 Protein, His-tagged
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Cat.#:DKC1-2787CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DKC1
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Cat.#:DKC1-3393ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DKC1
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Cat.#:DKC1-6916HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DKC1 293 Cell Lysate
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Involved Pathway

DKC1 involved in several pathways and played different roles in them. We selected most pathways DKC1 participated on our site, such as Cell Cycle, Chromosome Maintenance, Extension of Telomeres, which may be useful for your reference. Also, other proteins which involved in the same pathway with DKC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
GINS4; MCM8; H3F3B.1; CENPL; CENPA; ITGB3BP; GADD45B; CEP78; ORC4; CCNH
Chromosome Maintenance
HJURP; SMARCA5; RUVBL2; CENPH; POT1A; CENPI; MIS18BP1; MLF1IP; CENPQ; TERF1
Extension of Telomeres
RUVBL2; DKC1; WRAP53
Regulation of Telomerase
CMTM2A; PINX1; TNKS; SP3; DKC1; NR2F2; MXD1
Ribosome biogenesis in eukaryotes
DKC1; WDR36; NVL; SPATA5; XPO1; XRN2; SMFN; UTP18; NHP2; RIOK1
Telomere Extension By Telomerase
WRAP53; DKC1
Telomere Maintenance
DKC1; WRAP53

Protein Function

DKC1 has several biochemical functions, for example, RNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DKC1 itself. We selected most functions DKC1 had, and list some proteins which have the same functions with DKC1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein RPL30; DDX25; SRRM4; NHP2L1B; MRPL23; MIF4GDA; RNASEH2A; RBM4B; ZBP1; CELF1
Function poly(A) RNA binding
Related Protein PPP1R2P9; FXR2; MTERF; EBNA1BP2; PRKDC; NGDN; SNRPN; ZFP768; FASTKD2; RPGR
Function protein binding
Related Protein FAM164C; TBX24; GH1; PHF16; ALCAM; IL23; HNRNPUL1; SEC23IP; NRBF2; SF3B2
Function pseudouridine synthase activity
Related Protein RPUSD1; PUSL1; PUS7L; TRUB2; PUS3; DKC1; PUS1; RPUSD3; RPUSD4; PUS7
Function telomerase RNA binding
Related Protein TERT; HNRNPC; PINX1; NOP10; GAR1; NHP2; WRAP53; DKC1; HNRNPU
Function telomerase activity
Related Protein PRIM2; TERT; PTGES3; CCDC111; CTU1; UAP1L1; DKC1

Interacting Protein

DKC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DKC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DKC1.
NAF1; WRAP53; RUVBL1

DKC1 Related Articles

Cerrudo, CS; Gomez, DLM; et al. Novel Insights into the Evolution and Structural Characterization of Dyskerin Using Comprehensive Bioinformatics Analysis. JOURNAL OF PROTEOME RESEARCH 14:874-887(2015).
Gao, JJ; Roy, S; et al. Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. ENVIRONMENTAL RESEARCH 136:462-469(2015).