dock2
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  • Official Full Name
  • dedicator of cytokinesis 2
  • Background
  • The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
  • Synonyms
  • DOCK2; dedicator of cytokinesis 2; dedicator of cytokinesis protein 2; dedicator of cyto-kinesis 2;
Cat.#:DOCK2-2805HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DOCK2 Protein, GST-tagged
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Cat.#:DOCK2-402HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DOCK2 Protein, His-tagged
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Cat.#:DOCK2-503HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DOCK2 cell lysate
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Involved Pathway

DOCK2 involved in several pathways and played different roles in them. We selected most pathways DOCK2 participated on our site, such as Chemokine signaling pathway, Disease, Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
CCL28; GM13304; PIK3R3; CCL6; PIK3R1; GNG8; JAK2; GNG12; CCL15; SHC2
Disease
MMAA; SFTPC; FDX1; KREMEN1; HDAC6; TIRAP; PPIAL4A; SYT2; CHMP4B; COBRA1
Factors involved in megakaryocyte development and platelet production
KIF3B; IRF1B; KIF3A; GATA6; DOCK9; H3F3B.1; MYB; HBG2; KIF9; KDM1A
Fc gamma R-mediated phagocytosis
VAV3; PPAP2A; ARPC1A; PLCG2; GSN; ARPC5L; MARCKSL1; PRKCE; LYN; SCIN
HIV Infection
VPS37A; PDCD6IP; CHMP4C; TAF1L; NMT2; AP1G1; PACS1; CDK9; RCC1; AP1B1
Hemostasis
CD177; DOK2; F3A; BRPF3; PLEK; CENPE; SPARC; GNA13B; OSTN; ANXA2
Host Interactions of HIV factors
AP1S1; PPIAL4A; AP1B1; RCC1; PSIP1; AP1G1; AP1M2; PACS1; APOBEC3G; DOCK2
Infectious disease
LTF; VPS37A; NMT2; PACS1; RCC1; AP1S1; TAF1L; NMT1; IPO5; KPNA5

Protein Function

DOCK2 has several biochemical functions, for example, GTPase activator activity, Rac guanyl-nucleotide exchange factor activity, T cell receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK2 itself. We selected most functions DOCK2 had, and list some proteins which have the same functions with DOCK2. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein ARHGAP35; RIN1; SRGAP1; RGS19; RGS14A; ARHGAP40; RAP1GDS1; ARHGDIG; RGS6; TBC1D9
Function Rac guanyl-nucleotide exchange factor activity
Related Protein DOCK2; SPATA13; FARP2; ALS2; FARP1; ARHGEF4; ARHGEF2; PREX2; VAV3; VAV1
Function T cell receptor binding
Related Protein CD1d1; H2-Q10; CD3G; EPS8L1; FYN; HLA-A; CD3E; DOCK2
Function protein binding
Related Protein SSTR2; PYCRL; ZNF329; ADORA1; CRYBB3; Unc5b; BMPR1B; SMARCD1; HSPB6; CLTC

Interacting Protein

DOCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK2.
RAC1; PLSCR1; CCNDBP1; KRTAP5-9; TRIM23

DOCK2 Related Articles

Thackray, LB; Shrestha, B; et al. Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection. JOURNAL OF VIROLOGY 88:11007-11021(2014).
Eguchi, K; Yoshioka, Y; et al. The Drosophila DOCK family protein sponge is involved in differentiation of R7 photoreceptor cells. EXPERIMENTAL CELL RESEARCH 319:2179-2195(2013).