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DOCK2

  • Official Full Name

    dedicator of cytokinesis 2

  • Overview

    The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
  • Synonyms

    DOCK2; dedicator of cytokinesis 2; dedicator of cytokinesis protein 2; dedicator of cyto-kinesis 2;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOCK2-2805H Recombinant Human DOCK2 Protein, GST-tagged Wheat Germ GST
Human DOCK2-503HCL Recombinant Human DOCK2 cell lysate N/A
Human DOCK2-3935HF Recombinant Full Length Human DOCK2 Protein, GST-tagged In Vitro Cell Free System GST 336 amino acids
Human DOCK2-402H Recombinant Human DOCK2 Protein, His-tagged E.coli His Ile390~Glu635
Human DOCK2-1981H Recombinant Human DOCK2 Protein (Ile390-Glu635), His tagged E.coli His Ile390-Glu635
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DOCK2 Related Articles
  • DOCK2 Related Research Area
  • DOCK2 Related Signal Pathway

DOCK2 involved in several pathways and played different roles in them. We selected most pathways DOCK2 participated on our site, such as Chemokine signaling pathway, Disease, Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayPIK3CD;BCAR1;RAC1;GNAI3;CXCL10;CCR7;RAC2;Cxcl15;IL-8
DiseaseARF1;AP1M2;CCDC167;CFTR;OPN1SW;RNF43;CCR5;RPL35;HEY2
Factors involved in megakaryocyte development and platelet productionKIF2A;KIFC1;BA2;AKAP1B;KIF22;ITPK1;DOCK8;GATA5;DOCK10
Fc gamma R-mediated phagocytosisLAT;RPS6KB2;INPPL1;SCIN;FCGR1A;PLD1;PIK3CG;ARPC1A;GSN
HIV InfectionCHMP4B;TCEB3;PPIAL4A;AP1B1;CHMP4C;APOBEC3G;SSRP1;ELL;PDCD6IP
HemostasisGATA2;GRB7;TRPC3;ABHD6B;HMG20B;CLU;TFA;DOCK10;SPARC
Host Interactions of HIV factorsAP1S1;PSIP1;AP1G1;AP1M2;AP1B1;PACS1;PPIAL4A;DOCK2;APOBEC3G
Infectious diseaseSTX1B;IPO5;NMT1;CHMP4C;SYT2;LTF;PDCD6IP;APOBEC3G;CCDC167

DOCK2 has several biochemical functions, for example, GTPase activator activity, Rac guanyl-nucleotide exchange factor activity, T cell receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK2 itself. We selected most functions DOCK2 had, and list some proteins which have the same functions with DOCK2. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityEVI5L;RIC8B;TBC1D17;THY1;ALDH1A2;CHML;TBC1D13;AGAP2;ARFGAP3
Rac guanyl-nucleotide exchange factor activityVAV1;SPATA13;ARHGEF2;DOCK2;ALS2;VAV3;FARP2;FARP1;ARHGEF4
T cell receptor bindingHLA-A;EPS8L1;H2-Q10;CD1d1;DOCK2;FYN;CD3G;CD3E
protein bindingCD164;ATP6V1G1;TERF1;GATSL3;CIB2;CBX4;MOBKL2B;SNAPIN;HIST2H4A

DOCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK2.

RAC1; PLSCR1; CCNDBP1; KRTAP5-9; TRIM23

Thackray, LB; Shrestha, B; et al. Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection. JOURNAL OF VIROLOGY 88:11007-11021(2014).
Eguchi, K; Yoshioka, Y; et al. The Drosophila DOCK family protein sponge is involved in differentiation of R7 photoreceptor cells. EXPERIMENTAL CELL RESEARCH 319:2179-2195(2013).
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