dock9
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  • Official Full Name
  • dedicator of cytokinesis 9
  • Background
  • Dock9 (Dedicator of cytokinesis 9), also known as Zizimin1, is a large (~230 kDa) protein involved in intracellular signalling networks.It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins. Dock9 activates the small G protein Cdc42.
  • Synonyms
  • DOCK9; dedicator of cytokinesis 9; dedicator of cytokinesis protein 9; KIAA1058; ZIZ1; zizimin1; Cdc42 guanine nucleotide exchange factor zizimin 1; DKFZp686C11110; DKFZp686D2047; DKFZp686N04132; DOCK 9; FLJ16744; FLJ44528; FLJ45282; FLJ45601; KIAA1085; cdc42 guanine nucleotide exchange factor zizimin-1; RP11-155N3.2
Cat.#:DOCK9-12124HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DOCK9, His-tagged
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Involved Pathway

DOCK9 involved in several pathways and played different roles in them. We selected most pathways DOCK9 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, Regulation of CDC42 activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK9 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Factors involved in megakaryocyte development and platelet production
IRF2; AKAP10; D-AKAP2; KIF18A; ZFPM1; MFN2; ZFPM2A; DOCK11; GATA2; KIF9
Hemostasis
PRKCHB; IRF2; SLC7A11; AKAP1B; GNA13; CAP1; KIF11; CALU; SERPINF2B; RACGAP1
Regulation of CDC42 activity
RALBP1; SPATA13; DNMBP; ITSN2; MCF2L; ARHGAP1; ARHGEF25; BCAR3; DOCK10; ARHGAP17

Protein Function

DOCK9 has several biochemical functions, for example, Rho GTPase binding, Rho guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK9 itself. We selected most functions DOCK9 had, and list some proteins which have the same functions with DOCK9. You can find most of the proteins on our site.
Function
Related Protein
Function Rho GTPase binding
Related Protein IQGAP3; PARD6A; DAAM1B; ECT2; DIAPH3; FLNA; LRRK2; DIAP1; ARHGEF16; ROCK2A
Function Rho guanyl-nucleotide exchange factor activity
Related Protein FARP1; ARHGEF7A; ARHGEF39; SOS1; DOCK11; MCF2L; ARHGEF17; FGD4A; ARHGEF15; ARHGEF40
Function protein binding
Related Protein RYR2; TXN2; PPM1B; C2orf51; SKA1; PSAP; DLGAP1; ITCH; CRNKL1; IL36RN

Interacting Protein

DOCK9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK9 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK9.
SMAD3; SMAD2; NEB; ATG12; SNAPIN; TAF1; HTT; CLK1; FHL1; NEDD9; PPP2R5E; NUCKS1; MYOT

DOCK9 Related Articles

Gadea, G; Blangy, A; et al. Dock-family exchange factors in cell migration and disease. EUROPEAN JOURNAL OF CELL BIOLOGY 93:466-477(2014).
Burdon, KP; Vincent, AL; et al. Insights into keratoconus from a genetic perspective. CLINICAL AND EXPERIMENTAL OPTOMETRY 96:146-154(2013).