DOT1L
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Official Full Name
DOT1-like histone H3K79 methyltransferase
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Overview
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011] -
Synonyms
DOT1L; DOT1-like histone H3K79 methyltransferase; DOT1; KMT4; histone-lysine N-methyltransferase, H3 lysine-79 specific; H3-K79-HMTase; DOT1-like protein; lysine N-methyltransferase 4; histone methyltransferase DOT1L; histone H3-K79 methyltransferase; DOT1-like, histone H3 methyltransferase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- E. coli
- E.coli
- HEK293
- Insect Cell
- Wheat Germ
- GST
- His
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | DOT1L-180H | Active Recombinant Human DOT1L protein, GST-tagged | Insect Cell | GST | 1-435 aa | |
Human | DOT1L-2821H | Recombinant Human DOT1L Protein, GST-tagged | Wheat Germ | GST | ||
Human | DOT1L-658H | Recombinant Human DOT1L, GST-tagged | E.coli | GST | ||
Human | DOT1L-27742TH | Recombinant Human DOT1L | E.coli | N/A | ||
Human | DOT1L-767H | Recombinant Human DOT1L protein | E.coli | N/A | Gly2-Lys416 | |
Human | DOT1L-6841HCL | Recombinant Human DOT1L 293 Cell Lysate | HEK293 | N/A | ||
Human | DOT1L-006H | Recombinant Human DOT1L Protein, GST-tagged | E.coli | GST | 2-416 | |
Human | DOT1L-2979H | Recombinant Human DOT1L protein, His-tagged | E.coli | His | 511-698 aa | |
Human | DOT1L21203H | Recombinant Human Dot1L (1-351) Protein | ||||
Human | DOT1L3226H | Recombinant Human Dot1L (1-416) Protein | ||||
Human | DOT1L-130H | Recombinant Human DOT1L Protein, GST-tagged | E. coli | GST | 2-416 |
- Involved Pathway
- Protein Function
- Interacting Protein
- DOT1L Related Research Area
DOT1L involved in several pathways and played different roles in them. We selected most pathways DOT1L participated on our site, such as Lysine degradation, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOT1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Lysine degradation | ALDH7A1;ALDH9A1B;SETD1BA;SETD1B;GCDHA;SUV39H2;AGXT2L2;PLOD1;COLGALT2 |
Transcriptional misregulation in cancer | HIST1H3F;FLT3;HIST1H3A;ETV7;MDM2;MPO;H3F3C;EWSR1;TSPAN7 |
DOT1L has several biochemical functions, for example, DNA binding, histone methyltransferase activity (H3-K79 specific), histone-lysine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOT1L itself. We selected most functions DOT1L had, and list some proteins which have the same functions with DOT1L. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
DNA binding | RXRA;SOX1A;HIST1H4E;FANCI;EGR3;ENG2A;PBRM1;PAX3A;ARID3C |
histone methyltransferase activity (H3-K79 specific) | |
histone-lysine N-methyltransferase activity | PRDM7;EZH2;SMYD1;SUV39H1B;EHMT2;SETD1BA;SETD8;WHSC1L1;SMYD3 |
protein binding | PHAX;MED26;ZNF695;TLR3;RAB3B;NAMPT;SPOP;CCL3;RCBTB2 |
transcription factor binding | UBE2I;PBX2;RB1;RORA;PPARGC1A;PPP1R13B;NAB2;SLC26A5;C1QBP |
DOT1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOT1L here. Most of them are supplied by our site. Hope this information will be useful for your research of DOT1L.
MLLT3; MLLT1; MLLT10; MLLT6; HIST2H3D
- Q&As
- Reviews
Q&As (7)
Ask a questionDOT1L modulates transcriptional regulation, affecting gene expression patterns in different cell types.
Variations in DOT1L activity impact cellular aging and may contribute to age-related diseases.
DOT1L influences embryonic development and stem cell differentiation through epigenetic regulation.
DOT1L contributes to leukemia development, especially in MLL-rearranged cases, by altering gene expression.
DOT1L regulates gene expression by methylating histone H3, affecting chromatin and gene activity.
DOT1L plays a crucial role in chromatin structure and stability, influencing genomic integrity.
Inhibiting DOT1L shows promise in epigenetic cancer therapies by modifying disease-related gene expression.
Customer Reviews (3)
Write a reviewEfficient protein purification, consistently delivers high yield and purity.
Precise protein quantification, ensures data precision in our experiments.
Dependable peptide synthesis, accelerates our peptide-focused projects effectively.
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