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DRD3

  • Official Full Name

    dopamine receptor D3

  • Overview

    This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is expressed in phylogenetically older regions of the brain, suggesting that it plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
  • Synonyms

    D3DR; ETM1; FET1; MGC149204; MGC149205; dopamine receptor D3; DRD3; D(3) dopamine receptor; OTTHUMP00000214909; OTTHUMP00000214910; OTTHUMP00000214911; essential tremor 1; dopamine D3 receptor;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DRD3-2945H Recombinant Human DRD3 protein, His-tagged E.coli His
Human DRD3-1100HFL Recombinant Human DRD3 protein, His&Flag-tagged HEK293 His&Flag 1-400 aa
Mouse DRD3-4824M Recombinant Mouse DRD3 Protein Mammalian Cell His
Mouse DRD3-2528M Recombinant Mouse DRD3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DRD3-2528M-B Recombinant Mouse DRD3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Drd3-1382M Recombinant Mouse Drd3 Protein, His&GST-tagged E.coli N-His&GST Met1-Asn65
Rat DRD3-1957R Recombinant Rat DRD3 Protein Mammalian Cell His
Rat DRD3-1616R Recombinant Rat DRD3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DRD3-1616R-B Recombinant Rat DRD3 Protein Pre-coupled Magnetic Beads HEK293
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) RFL3385CF Recombinant Full Length Chlorocebus Aethiops D(3) Dopamine Receptor Protein, His-Tagged E.coli expression system His Full Length (1-400)
Homo sapiens (Human) RFL12868HF Recombinant Full Length Human D(3) Dopamine Receptor(Drd3) Protein, His-Tagged E.coli expression system His Full Length (1-400)
Mus musculus (Mouse) RFL29108MF Recombinant Full Length Mouse D(3) Dopamine Receptor(Drd3) Protein, His-Tagged E.coli expression system His Full Length (1-446)
Pan troglodytes (Chimpanzee) RFL32890PF Recombinant Full Length Pan Troglodytes D(3) Dopamine Receptor(Drd3) Protein, His-Tagged E.coli expression system His Full Length (1-400)
Rattus norvegicus (Rat) RFL28067RF Recombinant Full Length Rat D(3) Dopamine Receptor(Drd3) Protein, His-Tagged E.coli expression system His Full Length (1-446)
Rhesus Macaque DRD3-1330R Recombinant Rhesus monkey DRD3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DRD3-1155R-B Recombinant Rhesus Macaque DRD3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DRD3-1155R Recombinant Rhesus Macaque DRD3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DRD3-9690Z Recombinant Zebrafish DRD3 Mammalian Cell His
Kit-0983 Fluorimetric HDAC Activity Assay Kit (Green) N/A
Kit-1216 DRD3 U2OS β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DRD3 involved in several pathways and played different roles in them. We selected most pathways DRD3 participated on our site, such as Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), Dopamine receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amine ligand-binding receptorsCHRM1;DRD2;CHRM5;ADRA2A;ADRA1D;TAAR1;ADRA2B;DRD4;ADRA1B
Class A/1 (Rhodopsin-like receptors)CCR9;ANXA1;SSTR5;EDN3;PYY;GPR18;ADRB2;TRH;DRD3
Dopamine receptorsDRD3;DRD5;DRD4;DRD2;DRD1
Dopaminergic synapseARNTL;PLCB4;PPP2R5C;KCNJ6;GNG7;CALY;KCNJ9;CAMK2G;SLC18A1
G alpha (i) signalling eventsHCAR1-2;POMCB;RGS21;CXCL13;ANXA1;CCR1;FPR-RS4;ADORA1;OPN1MW
GPCR downstream signalingEDN1;RGS1;PROKR2;CXCR6;ADRA2B;SCT;GPR132B;ADORA2A;CHRM2
GPCR ligand bindingQRFP;CCL35.1;TAC2;OPN1MW;GNB5A;NTS;NMUR1;ZFPM2B;SCT
GPCRs, Class A Rhodopsin-likeACKR4;GPR171;CNR2;OPN1LW;GPR18;GPR32;GPR65;CCR1;PTGDR2

DRD3 has several biochemical functions, for example, D1 dopamine receptor binding, G-protein coupled amine receptor activity, dopamine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DRD3 itself. We selected most functions DRD3 had, and list some proteins which have the same functions with DRD3. You can find most of the proteins on our site.

Function Related Protein
D1 dopamine receptor bindingATP1A3;GNAS;DRD3;ARRB2;AGTR1A;PTPN11;DLG4;CAV2
G-protein coupled amine receptor activityDRD4B;TAAR4;TAAR8A;TAAR2;GPR161;DRD4-RS;TAAR8C;DRD4A;DRD5
dopamine bindingADRB2;DRD5;DRD1A;DRD2;DRD2A;SLC6A3;DRD1B;DRD3;GPR143
dopamine neurotransmitter receptor activity, coupled via Gi/GoDRD3;DRD2B;DRD2;DRD2A;DRD2L;DRD4A;DRD4B;DRD4;DRD4-RS
drug bindingPPARG;DRD4;FSCN1;MT3;GRIK1;DHODH;RARB;TLR7;DRD3
protein bindingSUN1;CDKN1A;MUM1;CCDC86;FOXH1;BRAT1;SSX3;DNAJC15;CHPF
protein domain specific bindingSTRN4;ERCC1;AIDA;CALM;WHRN;DRD3;XPO1;CALM1;HIST1H4D

DRD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRD3.

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