drd3
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  • Official Full Name
  • dopamine receptor D3
  • Background
  • This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is expressed in phylogenetically older regions of the brain, suggesting that it plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
  • Synonyms
  • D3DR; ETM1; FET1; MGC149204; MGC149205; dopamine receptor D3; DRD3; D(3) dopamine receptor; OTTHUMP00000214909; OTTHUMP00000214910; OTTHUMP00000214911; essential tremor 1; dopamine D3 receptor
Cat.#:DRD3-4824MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DRD3 Protein
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Cat.#:DRD3-1957RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DRD3 Protein
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Cat.#:DRD3-1330RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DRD3 Protein, His-tagged
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Cat.#:DRD3-9690ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DRD3
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Cat.#:Kit-0983Tag:
Source (Host):Species:
Product nameFluorimetric HDAC Activity Assay Kit (Green)
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Cat.#:Kit-1216Tag:
Source (Host):Species:
Product nameDRD3 U2OS β-Arrestin GPCR Assay Kit
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Involved Pathway

DRD3 involved in several pathways and played different roles in them. We selected most pathways DRD3 participated on our site, such as Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), Dopamine receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amine ligand-binding receptors
ADRa1A; ADRA2A; CHRM4; CHRM2; DRD4; ADRB3; ADRA1D; CHRM3; ADRB2; DRD5
Class A/1 (Rhodopsin-like receptors)
EDNRB; ADRa1A; TAAR1; MLN; CHRM5; ADRB3; CCR8; GPR37L1; OPN1LW1; PPY
Dopamine receptors
DRD2; DRD3; DRD1; DRD4; DRD5
Dopaminergic synapse
PPP2R1B; DRD2; ITPR3; GNG7; DRD5; DRD4; SLC18A1; GNGT2; GRIN2A; KCNJ9
G alpha (i) signalling events
CNR1; OXGR1A.1; SSTR1; TAS2R7; LPAR2A; CCL35.2; CXCR7B; SST1.1; RGS18; CHRM4
GPCR downstream signaling
GCGA; MLN; CNR1; LPAR2A; FPR-RS6; OXGR1A.3; CCR6; RHOGA; PIK3R6; SSTR4
GPCR ligand binding
KISS1; LPAR2A; PYY; NMBA; CCL27; CYSLTR1; ADRA2B; GPBAR1; CALCA; NMB
GPCRs, Class A Rhodopsin-like
OPN1MW; CCR3; SSTR5; CCRL2; GPR77; GPR68; FPR-RS4; OR3A4P; GPR20; CCR7

Protein Function

DRD3 has several biochemical functions, for example, D1 dopamine receptor binding, G-protein coupled amine receptor activity, dopamine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DRD3 itself. We selected most functions DRD3 had, and list some proteins which have the same functions with DRD3. You can find most of the proteins on our site.
Function
Related Protein
Function D1 dopamine receptor binding
Related Protein CAV2; GNAS; PTPN11; DLG4; AGTR1A; ATP1A3; ARRB2; DRD3
Function G-protein coupled amine receptor activity
Related Protein DRD4-RS; DRD1B; TAAR7D; DRD4A; DRD1A; DRD5; TAAR8A; TAAR13C; TAAR7B; DRD1
Function dopamine binding
Related Protein DRD1B; SLC6A3; DRD5; DRD1A; ADRB2; DRD2L; GPR143; DRD1; DRD2A; DRD2B
Function dopamine neurotransmitter receptor activity, coupled via Gi/Go
Related Protein DRD2L; DRD2B; DRD2; DRD3; DRD4-RS; DRD4; DRD2A; DRD4A; DRD4B
Function drug binding
Related Protein CHRNB3; GSTP2; HMGCS1; HTR2B; Alb; ABP1; GLRB; DHFR; PDE10A; HTR1B
Function protein binding
Related Protein SNAPC3; EME1; PTGES2; GCC1; BRIP1; TBC1D17; EID1; SPG7; ZNF223; TRIM33
Function protein domain specific binding
Related Protein PKD1; TRP63; MYH9; HIST1H4D; SNCA; SLC34A2; YWHAG1; ARL1; ACTN2; ANGEL1