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DST

Official Full Name

dystonin
Overview

This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration.
Synonyms

DST; dystonin; BPAG1, bullous pemphigoid antigen 1, 230/240kDa; bullous pemphigoid antigen 1; BP240; BPA; CATX 15; FLJ13425; FLJ21489; FLJ30627; FLJ32235; KIAA0728; MACF2; 230 kDa bullous pemphigoid antigen; 230/240 kDa bullous pemphigoid antigen; BP230; BPAG1; Bullous pemphigoid antigen; DMH; DT; Dystonia musculorum protein; Hemidesmosomal plaque protein; trabeculin-beta; OTTHUMP00000016653; OTTHUMP00000016654; OTTHUMP00000016655; OTTHUMP00000016657; OTTHUMP00000016658; OTTHUMP00000224445; CATX15; CATX-15; D6S1101;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human

Source

E. coli
E.coli
HEK293
Mammalian Cell
Wheat Germ
Yeast

Tag

C
His
GST
His|SUMO
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DST-2893H	Recombinant Human DST Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DST-1196H	Recombinant Human DST Protein, His-SUMO-tagged	E.coli	His/SUMO		Inquiry
Human	DST-26933TH	Recombinant Human DST	Wheat Germ	N/A	100 amino acids	Inquiry
Human	DST-156H	Recombinant Human DST	Mammalian Cell	His		Inquiry
Human	DST-688H	Recombinant Human DST Protein, His-tagged	E.coli	His	Met1~Thr252	Inquiry
Human	DST-2823H	Recombinant Human DST protein(6011-6580 aa), C-His-tagged	E. coli	C-His	6011-6580 aa	Inquiry
Human	DST-2208H	Recombinant Human DST Protein (Met1-Trp979), N-His tagged	E.coli	N-His	Met1-Trp979	Inquiry
Human	DST-2823H-B	Recombinant Human DST Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	DST-1693H	Recombinant Human DST Protein (1-195 aa), His-tagged	Yeast	His	1-195 aa	Inquiry
Human	DST-301443H	Recombinant Human DST protein, GST-tagged	E.coli	GST	Ser420-Asp610	Inquiry

Involved Pathway
Protein Function
Interacting Protein
DST Related Articles

DST involved in several pathways and played different roles in them. We selected most pathways DST participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Assembly of collagen fibrils and other multimeric structures, Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with DST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Alpha6-Beta4 Integrin Signaling Pathway	EIF4EBP1;EIF4E;SMAD3B;MST1R;CDKN1A;CD151L;EIF4EB;CD151;DSP
Assembly of collagen fibrils and other multimeric structures	COL11A1B;LOXL4;COL5A1;COL5A2;COL1A1;COL8A1;COL2A1;CTSL1;COL6A2
Cell junction organization	CDH6;CDH12;CLDN16;CDH11;CDH9;ITGB1B.1;F11R.2;JUP;CDH17
Cell-Cell communication	CLDN3;CDH11;CDH4;CDH2;CADM2;JUP;F11R.2;DSCAML1;CDH5
Collagen formation	COL5A1;COL1A2;COL28A1A;COL6A2;CTSS;LOXL2;LEPREL2;LEPREL1;COL13A1
Extracellular matrix organization	TLL2;TTR;MFAP4;MFAP3;TIMP2;DST;TIMP2A;COL4A3;LEPRE1
Type I hemidesmosome assembly	DST;CD151;PLECA;COL17A1A

DST has several biochemical functions, for example, actin binding, calcium ion binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DST itself. We selected most functions DST had, and list some proteins which have the same functions with DST. You can find most of the proteins on our site.

Function	Related Protein
actin binding	SYN1;PARVA;GBP1;C19orf21;WASF1;EPB49;LRRC10;MACF1;FHL3
calcium ion binding	CABP1B;BGLAP-RS1;EFEMP2B;SYT1B;CETN1;CIB4;CALM4;RCVRNA;PCDHGA6
integrin binding	NISCH;DST;ICAM3;COL3A1;GFAP;GPNMB;WISP1A;FCER2;TNN
microtubule plus-end binding	DST;MAPRE1;CLIP1;APC;CLASP1A;CLIP2;CLASP1;KIF2C;STIM1
protein C-terminus binding	OPRL1;SIAH1A;CSK;ZBTB16;PPP2CB;PABPC1;KCNIP3;SDCBP;DAB2
protein binding	LACTB2;RYR1B;PCBD2;TREML1;EIF2S1;UBE2E3;TESK2;RNF139;HYPM
protein homodimerization activity	CLIC6;DRD2;HMGCS1;UGT1A9;RXRB;NR4A2;IRAK1;DMRTB1;HOMER2

DST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DST here. Most of them are supplied by our site. Hope this information will be useful for your research of DST.

Mapre1; MAPRE1; OPTN; APPL1; AKR1B1; NFKB1; CBFB; RNPS1; PUF60; SMAD9; TULP3

Kalache, S; Lakhani, P; et al. Effects of Preexisting Autoimmunity on Heart Graft Prolongation After Donor-Specific Transfusion and Anti-CD154. TRANSPLANTATION 97:12-19(2014).

Wang, YT; Wang, H; et al. Rapid Dendritic Cell Activation and Resistance to Allotolerance Induction in Anti-CD154-Treated Mice Receiving CD47-Deficient Donor-Specific Transfusion. CELL TRANSPLANTATION 23:355-363(2014).