DYSF
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Official Full Name
dysferlin
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Overview
The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2008] -
Synonyms
DYSF; dysferlin; MMD1; FER1L1; LGMD2B; fer-1-like protein 1; dystrophy-associated fer-1-like 1; dystrophy-associated fer-1-like protein; limb girdle muscular dystrophy 2B (autosomal recessive); dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive);
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | DYSF-2773H | Recombinant Human DYSF Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | DYSF-4000H | Recombinant Human DYSF Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | DYSF-684H | Recombinant Human DYSF Protein, His-tagged | E.coli | His | Met1~Tyr479 | |
Human | DYSF-796H | Recombinant Human DYSF Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | DYSF-518HFL | Recombinant Full Length Human DYSF Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | DYSF-796H-B | Recombinant Human DYSF Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Dysf-2703M | Recombinant Mouse Dysf Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Zebrafish | DYSF-8213Z | Recombinant Zebrafish DYSF | Mammalian Cell | His |
- DYSF Related Articles
DYSF involved in several pathways and played different roles in them. We selected most pathways DYSF participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DYSF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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DYSF has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DYSF itself. We selected most functions DYSF had, and list some proteins which have the same functions with DYSF. You can find most of the proteins on our site.
Function | Related Protein |
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DYSF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYSF here. Most of them are supplied by our site. Hope this information will be useful for your research of DYSF.
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, some variants in the DYSF gene are associated with insulin resistance, which may be one of the reasons for its increased risk of type 2 diabetes.
The protein encoded by the DYSF gene is a muscle-specific kinase that plays an important role in the structure and function of muscle cells.
There is currently no definitive way to alter the variant in the DYSF gene. However, the risk of type 2 diabetes can be reduced by adhering to a healthy lifestyle, such as eating a balanced diet, exercising moderately, avoiding excessive stress, etc.
There is currently no specific treatment or intervention for the DYSF gene variant. However, the risk of type 2 diabetes can be reduced through a combination of measures such as lifestyle modifications and medications.
Yes, some variants in the DYSF gene are also involved in β cell function, which may also be one of the reasons why it affects the risk of type 2 diabetes.
Variants in the DYSF gene include single nucleotide polymorphisms (SNPs), insertions/deletions, and some of these variants are associated with an increased risk of type 2 diabetes.
Customer Reviews (3)
Write a reviewIt has good stability and is suitable for long-term storage.
The detection method is sensitive and can detect trace amounts of protein, which is very suitable for our research.
DYSF is easy to operate and improves the efficiency of the experiment.
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