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DAXX

  • Official Full Name

    death-domain associated protein

  • Overview

    Daxx is a ubiquitously expressed protein that was originally identified through a yeast two-hybrid screen as an interactor with the cytoplasmic domain of Fas. It was found to enhance Fas-mediated apoptosis and activate the JNK pathway (1). However, additi
  • Synonyms

    DAXX; death-domain associated protein; death associated protein 6; death domain-associated protein 6; DAP6; Fas-binding protein; CENP-C binding protein; ETS1-associated protein 1; death-associated protein 6; fas death domain-associated protein; EAP1; BING2; MGC126245; MGC126246;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DAXX-2352H Recombinant Human DAXX Protein, GST-tagged Wheat Germ GST
Human DAXX-11834H Recombinant Human DAXX, GST-tagged E.coli GST 1-349a.a.
Human DAXX-7071HCL Recombinant Human DAXX 293 Cell Lysate HEK293 N/A
Human DAXX-1182H Recombinant Human DAXX Protein (1-233 aa), GST-tagged E.coli GST 1-233 aa
Human DAXX-418H Recombinant Human DAXX Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human DAXX-717H-B Recombinant Human DAXX Protein Pre-coupled Magnetic Beads HEK293
Human DAXX-335HFL Active Recombinant Full Length Human DAXX Protein, C-Flag-tagged Mammalian cells Flag
Human DAXX-4829H Recombinant Human DAXX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DAXX-2009H Recombinant Human DAXX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DAXX-1315H Recombinant Human DAXX Protein, His&GST-tagged E.coli N-His&GST Met1-Pro160
Human DAXX-717H Recombinant Human DAXX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DAXX-2536HF Recombinant Full Length Human DAXX Protein, GST-tagged In Vitro Cell Free System GST 740 amino acids
Mouse DAXX-4311M Recombinant Mouse DAXX Protein Mammalian Cell His
Mouse Daxx-2458M Recombinant Mouse Daxx Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DAXX-2205M Recombinant Mouse DAXX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DAXX-2205M-B Recombinant Mouse DAXX Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DAXX-4046Z Recombinant Zebrafish DAXX Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DAXX Related Articles
  • DAXX Related Research Area
  • DAXX Related Signal Pathway

DAXX involved in several pathways and played different roles in them. We selected most pathways DAXX participated on our site, such as Amyotrophic lateral sclerosis (ALS), Androgen receptor signaling pathway, Apoptosis Modulation and Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAXX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amyotrophic lateral sclerosis (ALS)GRIN2B;BAD;GRIA1;NEFH;CCS;CASP9;TNF;PPP3CA;Casp3
Androgen receptor signaling pathwayKAT5;CARM1;GNB2L1;KAT7B;MYST2;KAT7;CTNNB2;RAD9A;RUNX2A
Apoptosis Modulation and SignalingCASP2;SEPT4;BCL2L10;BLK;BAG3;PTRH2;BOK;CDKN2A;CAPNS1
FAS pathway and Stress induction of HSP regulationLMNB2;DFFA;DAXX;FAF1
HIV-1 Nef: Negative effector of Fas and TNF-alphaDAXX;CRADD;CASP2;DFFA
Herpes simplex infectionIFNB;MED8;TBPL1;IFNA10;FAS;HLA-E;SKP2;POLR2A;MAPK9
IL-6 Signaling PathwayDAXX;BMX;EIF2A;CDK5R1B
Integrated Pancreatic Cancer PathwayTOP1;IL11;BRF1;MYT1;FKBP3;JUND;AGA;RAPGEF3;DAXX

DAXX has several biochemical functions, for example, androgen receptor binding, enzyme binding, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAXX itself. We selected most functions DAXX had, and list some proteins which have the same functions with DAXX. You can find most of the proteins on our site.

Function Related Protein
androgen receptor bindingKDM1A;CCNE1;CDK7;RNF14;FHL2;PRKCB;CALR;RAN;DDX5
enzyme bindingNCOA1;LDB2;TOP2A;RPS19BP1;UGT1A6;HLCS;TARBP2;ARPC4;HIST1H2AI
heat shock protein bindingHSPA1L;HDAC2;LMAN2;PDXP;DNAJC7;CDC37;LIMK1;BAX;IRAK1
histone bindingBRD7;LEF1;NPM1;ASF1B;HIST1H4D;CTCFL;HIST1H4A;PYGO2;ZMYND11
p53 bindingRNF34;ZNF385B;TAF3;ZFP385C;GSK3B;RNF20;PSME3;TP63;HSPD1
protein N-terminus bindingTP53;ACOX1;PEX19;MYO7A;EIF3E;STX5;PARP1;EXOC4;RPA2
protein bindingDES;HDAC3;GEMIN6;RFX4;ATG7;PYDC1;MCL1;C6orf108;HSPB9
protein homodimerization activityIZUMO3;UNC13A;NOS2;CEBPA;LRRK2;AMBP;PLEKHB1;ZFP652;FBXO4
protein kinase activator activityMARK2;AGAP2;PRKAG2;EPO;FAM58A;STK11;MAPK8IP2;NKX3;WNT11
protein kinase bindingPPP1R15A;ATF2;PPP1CC;CCNL1A;PIWIL1;BAG5;DCX;CCNB1;VRK1
receptor signaling protein activityARAF;PLCE1;DOK1;RAF1A;IL4R;NCR1;RGS14A;BAG1;PDCL
transcription corepressor activityZNF274;DAXX;HIPK2;NOC2L;YWHAB;LOXL2;PROX1;ATF7IP;E2F6
transcription factor bindingDR1;PRKDC;HES7;IFT172;TBL1X;RNF19A;NCOA2;TLE1;CCND1
ubiquitin protein ligase bindingPRKAR2A;TCEB2;GABARAP;SUMO1;AKTIP;TSG101;NPLOC4;SMC6;TRAF6

DAXX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAXX here. Most of them are supplied by our site. Hope this information will be useful for your research of DAXX.

MDM2; TP53

Schreiner, S; Kinkley, S; et al. SPOC1-Mediated Antiviral Host Cell Response Is Antagonized Early in Human Adenovirus Type 5 Infection. PLOS PATHOGENS 9:-(2013).
Weisbrod, AB; Zhang, LS; et al. Altered PTEN, ATRX, CHGA, CHGB, and TP53 Expression Are Associated with Aggressive VHL-Associated Pancreatic Neuroendocrine Tumors. HORMONES & CANCER 4:165-175(2013).
  • Q&As
  • Reviews

Q&As (5)

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How does DAXX protein interact with other cellular proteins in the context of clinical applications? 01/01/2023

DAXX protein interacts with a wide range of cellular proteins, including transcription factors, histones, and chromatin remodeling complexes, which has implications for its clinical relevance in various cellular processes.

What are the potential therapeutic implications of targeting DAXX protein? 09/03/2020

Targeting DAXX protein may have therapeutic implications in cancer treatment, as well as in aging-related diseases and neurodegenerative disorders, by modulating its functions and interactions with other cellular proteins.

Are there any clinical implications of DAXX protein in aging-related diseases? 02/22/2019

Studies have suggested that DAXX protein may have implications in aging-related diseases, particularly in relation to telomere dysfunction and cellular senescence.

How does DAXX protein contribute to the development of neurodegenerative diseases? 10/22/2017

DAXX protein has been implicated in neurodegenerative diseases through its involvement in cellular stress responses and protein aggregation, which are hallmarks of diseases such as Alzheimer's and Parkinson's.

Can DAXX protein be used as a therapeutic target for cancer treatment? 07/30/2016

DAXX protein has been identified as a potential therapeutic target for cancer treatment due to its involvement in regulating the activity of key oncogenes and tumor suppressor genes.

Customer Reviews (3)

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Reviews
01/29/2021

    Its ability to provide accurate and reliable results in this particular application makes it a preferred choice for researchers studying antigen-antibody interactions and immune responses.

    09/27/2019

      The DAXX protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.

      10/26/2018

        the DAXX protein has proven to be invaluable in protein electron microscopy structure analysis.

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