DBNL
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Official Full Name
drebrin-like
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Overview
Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin. -
Synonyms
DBNL; drebrin-like; ABP1; HIP55; SH3P7; HIP-55; drebrin-like protein; drebrin-F; cervical SH3P7; SH3 domain-containing protein 7; cervical mucin-associated protein; HPK1-interacting protein of 55 kDa; src homology 3 domain-containing protein HIP-55;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Human cells
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- DBNL Related Articles
- DBNL Related Research Area
DBNL involved in several pathways and played different roles in them. We selected most pathways DBNL participated on our site, such as Apoptosis, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with DBNL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | IRAK4;CAPN1B;PTBP3;STK26;AKT2L;CASP3B;TNF;BOK;PIK3CD |
| Apoptotic cleavage of cellular proteins | DBNL;DSG1;BMX;CLSPN;STK24;SPNA2;OCLN;PLECA;PTBP3 |
| Apoptotic execution phase | CTNNB2;HMGB2;CASP6L1;CASP8L1;STK26;STK24B;HIST1H1D;PLECA;OCLN |
| Caspase-mediated cleavage of cytoskeletal proteins | DBNLB;DBNLA;GAS2;PLEC;CASP6L1;PLECA;VIML;CASP6L2;ADD1 |
| JNK signaling in the CD4+ TCR pathway | DBNL;MAP4K1 |
| Programmed Cell Death | DBNL;DAPK3;STK26;DSG1;HMGB2A;DIABLOB;CASP6L1;RIPK3;HMGB2 |
| TCR Signaling Pathway | CD83;DBNL |
| TCR signaling in naive CD4+ T cells | DBNL;STK39;SLA2 |
DBNL has several biochemical functions, for example, actin binding, actin filament binding, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DBNL itself. We selected most functions DBNL had, and list some proteins which have the same functions with DBNL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | EPS8;INO80;WAS;ABLIM1;PLEKHH2;BCL7B;ACTN3;PHACTR1;SPTBN1 |
| actin filament binding | WIPF2B;FSCN1A;TRPV4;DBNLB;USH1C;FLNA;MYO1E;ADD2;RCSD1 |
| enzyme activator activity | PITRM1;CLPS;GLC8;CXCL1;TAB1;PRKCE;ALOX5AP;CTSA;ALDH1A2 |
| protein C-terminus binding | HAND2;SDCBP2;CALCOCO1;HSPG2;MED12;AP2A1;SDCBP;PPP2CB;SHANK1 |
| protein binding | CYCS;Clec4n;HHEX;SSX1;SLAMF1;PAK6;ATP7B;CASQ2;TTC37 |
| protein domain specific binding | RAP2B;IST1;BHLHE40;SNCA;ABCC2;CRB3;ETV6;SORBS2;YWHABB |
DBNL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBNL here. Most of them are supplied by our site. Hope this information will be useful for your research of DBNL.
SH2D4A; SH3BP2; SH2D4A; ACD; HERC2
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