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DDIT3

  • Official Full Name

    DNA-damage-inducible transcript 3

  • Overview

    GADD 153 has been described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. GADD153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and merabolic perturbations. GADD153 functions to block cells in G1 to S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD153 dimers away from “classical” C/EBP binding sites, recognizing instead unique “nonclassical” sites.
  • Synonyms

    DDIT3; DNA-damage-inducible transcript 3; DNA damage-inducible transcript 3 protein; C/EBP zeta; CHOP; CHOP10; GADD153; DDIT-3; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; growth arrest and DNA damage-inducible protein GADD153; CEBPZ; CHOP-10; MGC4154;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDIT3-130H Recombinant Human DNA-damage-inducible Transcript 3 E.coli His
Human DDIT3-1361H Recombinant Human DNA-damage-inducible Transcript 3, GST-tagged E.coli GST
Human DDIT3-2442H Recombinant Human DDIT3 Protein, GST-tagged Wheat Germ GST
Human DDIT3-126H Recombinant Human DDIT3 protein, T7/His-tagged E.coli T7/His
Human DDIT3-4948H Recombinant Human DNA-Damage-Inducible Transcript 3, His-tagged Human His
Human DDIT3-859H Recombinant Human DDIT3 Protein, GST-His-tagged E.coli GST/His
Human DDIT3-217H Recombinant Human DDIT3 Protein, GST/His-tagged E.coli GST/His
Human DDIT3-26512TH Recombinant Human DDIT3, His-tagged E.coli His
Human DDIT3-7027HCL Recombinant Human DDIT3 293 Cell Lysate HEK293 N/A
Human DDIT3-3923H Recombinant Human DDIT3 protein, His-tagged E.coli His 1-169 aa
Human DDIT3-2450HF Recombinant Full Length Human DDIT3 Protein, GST-tagged In Vitro Cell Free System GST 169 amino acids
Human DDIT3-1935H Recombinant Human DDIT3 Protein (Met1-Ala169), N-His tagged E.coli N-His Met1-Ala169
Human DDIT3-3639H Recombinant Human DDIT3 protein, GST-tagged E.coli GST 1-169 aa
Mouse DDIT3-4387M Recombinant Mouse DDIT3 Protein Mammalian Cell His
Mouse DDIT3-2255M Recombinant Mouse DDIT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DDIT3-2255M-B Recombinant Mouse DDIT3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ddit3-1655M Recombinant Mouse Ddit3 protein, His & GST-tagged E.coli His/GST Met1~Ala168 (Accession # P35639)
Rhesus Macaque DDIT3-1206R Recombinant Rhesus monkey DDIT3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DDIT3-1031R-B Recombinant Rhesus Macaque DDIT3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DDIT3-1031R Recombinant Rhesus Macaque DDIT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DDIT3-5226Z Recombinant Zebrafish DDIT3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DDIT3 Related Articles
  • DDIT3 Related Research Area

DDIT3 involved in several pathways and played different roles in them. We selected most pathways DDIT3 participated on our site, such as ATF-2 transcription factor network, ATF4 activates genes, ATF6-alpha activates chaperone genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDIT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ATF-2 transcription factor networkCBFB;HRK;RUVBL2;POU2F1;JUND;KCNA3;MAPK14;JDP2;GADD45A
ATF4 activates genesDDIT3;DCP2;EXOSC8;KCNA3
ATF6-alpha activates chaperone genesDDIT3;KCNA3
ATF6-alpha activates chaperonesYY2;DDIT3;KCNA3
AdipogenesisFOXC2;HMGA1;FRZB;NRIP1;AHR;CEBPD;NDN;GATA2A;AGPAT2
MAPK signaling pathwayTRP53;JUND;MKNK2A;RRAS;CACNA1G;HSPA6;NLK2;RPS6KAL;ACVR1C
Metabolism of proteinsNANP;ST8SIA2;PFDN1;PAPPAB;ADAMTS15;PCSK1;SAE1;GATA6;ALG2
Non-alcoholic fatty liver disease (NAFLD)NDUFS1;NDUFB5;PIK3CG;NDUFB9;NDUFA12;UQCRB;Casp3;XBP1;SOCS3

DDIT3 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, cAMP response element binding protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDIT3 itself. We selected most functions DDIT3 had, and list some proteins which have the same functions with DDIT3. You can find most of the proteins on our site.

Function Related Protein
DNA bindingMBD1B;DNASE1L2;RNF11;DNAJB6;ZNF143;BARHL1A;RNF141;TRP63;HOXA5
RNA polymerase II core promoter proximal region sequence-specific DNA bindingJUNBA;NR6A1;EBF1;HAND1;PLAG1;ASCL2;NCOA2;CREB3L2;FOSL1A
cAMP response element binding protein bindingCRTC2;CRTC1;KCNA3;CREM;CREB3;ATF2;CRTC1A;DAPK3;DDIT3
leucine zipper domain bindingPAWR;MKL1;NRL;ERC1;PMF1;CRX;DDIT3;DAPK3;KCNA3
protein bindingDNER;ACTA1;SMPD1;NOG;SLAMF6;HOXA10;ROCK1;FANCF;C1QTNF2
protein heterodimerization activityITGA3;DMBX1;HER1;HIST1H4C;BRAF;POLA1;SMAD2;TAF13;BMP2B
NOT protein homodimerization activityNUDT16L1;KCNA3;DDIT3;MSH6;MSH3;MYO9B;MLXIPL;EXT2;MECOM
transcription corepressor activitySKOR1A;SAP30;TRIB3;MTA1;JUNB;SP100;SAP18;DR1;NR0B2A
transcription factor activity, sequence-specific DNA bindingZFP551;NFYC;PPARA;PPARAB;HOMEZ;ATF4B2;KLF5;ZNF792;E2F8
transcription factor bindingAr;TFDP2;PELP1;SMARCD3;KCNA3;BRD7;IFT172;DRG1;SNF8
transcription regulatory region DNA bindingHDAC1;RREB1;FOXI1;TCF7L1A;CCNT1;IKZF3;TBL1X;FOXM1;KLF1
transcription regulatory region sequence-specific DNA bindingTBX18;SFPQ;NFE2L3;POU2F1;NR5A2;MEF2AA;NR5A1A;ARNTL1A;KDM3A
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingCAMTA2;EGR2;HOXA5;ARID3B;GLI3;ETV2;MEIS3;TLX1;CEBPG

DDIT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDIT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDIT3.

CEBPG; BATF; DBP; BACH1; CREB3; FOS; HBZ; ATF2; FOSL2; JUNB; ATF7; CEBPB; ATF3

Richards, M; Phoon, CW; et al. A New Class of Pluripotent Stem Cell Cytotoxic Small Molecules. PLOS ONE 9:-(2014).
Carvalheira, GM; Nozima, BHN; et al. DDIT3, STT3A (ITM1), ARG2 and FAM129A (Niban, C1orf24) in diagnosing thyroid carcinoma: variables that may affect the performance of this antibody-based test and promise. MODERN PATHOLOGY 26:611-613(2013).
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