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DKC1

Official Full Name

dyskeratosis congenita 1, dyskerin
Overview

This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Synonyms

DKC1; dyskeratosis congenita 1, dyskerin; DKC; CBF5; DKCX; NAP57; NOLA4; XAP101; H/ACA ribonucleoprotein complex subunit 4; CBF5 homolog; snoRNP protein DKC1; nucleolar protein NAP57; nucleolar protein family A member 4; nopp140-associated protein of 57 kDa;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DKC1-261H	Recombinant Human DKC1 protein, GST-tagged	Wheat Germ	GST	1 a.a. - 514 a.a.	Inquiry
Human	DKC1-6916HCL	Recombinant Human DKC1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	DKC1-570HF	Recombinant Full Length Human DKC1 Protein, GST-tagged	In Vitro Cell Free System	GST	514 amino acids	Inquiry
Human	DKC1-685H	Recombinant Human DKC1 Protein, His-tagged	E.coli	His	Arg298~Leu465	Inquiry
Mouse	Dkc1-686M	Recombinant Mouse Dkc1 Protein, His-tagged	E.coli	His	Arg298~Glu509	Inquiry
Rat	DKC1-1875R	Recombinant Rat DKC1 Protein	Mammalian Cell	His		Inquiry
Rat	DKC1-1533R	Recombinant Rat DKC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Dkc1-687R	Recombinant Rat Dkc1 Protein, His-tagged	E.coli	His	Lys298~Gly509	Inquiry
Rat	DKC1-1533R-B	Recombinant Rat DKC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	DKC1-1272R	Recombinant Rhesus monkey DKC1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	DKC1-1097R-B	Recombinant Rhesus Macaque DKC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	DKC1-1097R	Recombinant Rhesus Macaque DKC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	DKC1-3393Z	Recombinant Zebrafish DKC1	Mammalian Cell	His		Inquiry
Chicken	DKC1-2787C	Recombinant Chicken DKC1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
DKC1 Related Articles

DKC1 involved in several pathways and played different roles in them. We selected most pathways DKC1 participated on our site, such as Cell Cycle, Chromosome Maintenance, Extension of Telomeres, which may be useful for your reference. Also, other proteins which involved in the same pathway with DKC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell Cycle	CEP57;CKAP5;CENPI;CUL1B;SMC1A;SMC2;BRE;RAD21B;RBL2
Chromosome Maintenance	CENPO;ITGB3BP;NPM1;TINF2;APITD1;CENPP;CENPL;SMARCA5;TERF2
Extension of Telomeres	DKC1;RUVBL2;WRAP53
Regulation of Telomerase	NR2F2;SP3;CMTM2A;TNKS;PINX1;DKC1;MXD1
Ribosome biogenesis in eukaryotes	FBLL1;NXF1;NAT10;IMP3;RAN;PWP2H;RPP25;RPP40;GTPBP4
Telomere Extension By Telomerase	DKC1;WRAP53
Telomere Maintenance	DKC1;WRAP53

DKC1 has several biochemical functions, for example, RNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DKC1 itself. We selected most functions DKC1 had, and list some proteins which have the same functions with DKC1. You can find most of the proteins on our site.

Function	Related Protein
RNA binding	TLR13;RBM4;ILF3;RBMY1F;ZFR;SNRPA;SAMHD1;EIF4EB;DHX34
poly(A) RNA binding	RPS27.2;HLA-A;EIF4E;PPIL4;RPS26;DSP;MAK16;LSM14A;RBM12B2
protein binding	PPIAL4A;GK;COMP;CPNE1;RAB39B;MAGED1;OAS1A;ZNF490;EPHB4
pseudouridine synthase activity	PUS7L;PUS3;RPUSD2;RPUSD4;RPUSD1;RPUSD3;DKC1;PUS10;PUS7
telomerase RNA binding	PINX1;WRAP53;DKC1;TERT;NHP2;GAR1;HNRNPU;HNRNPC;NOP10
telomerase activity	CTU1;PRIM2;CCDC111;TERT;PTGES3;DKC1;UAP1L1

DKC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DKC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DKC1.

NAF1; WRAP53; RUVBL1

Cerrudo, CS; Gomez, DLM; et al. Novel Insights into the Evolution and Structural Characterization of Dyskerin Using Comprehensive Bioinformatics Analysis. JOURNAL OF PROTEOME RESEARCH 14:874-887(2015).

Gao, JJ; Roy, S; et al. Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. ENVIRONMENTAL RESEARCH 136:462-469(2015).