Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

DUSP5

  • Official Full Name

    dual specificity phosphatase 5

  • Overview

    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily.These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.
  • Synonyms

    DUSP5; dual specificity phosphatase 5; dual specificity protein phosphatase 5; HVH3; VH1-like phosphatase 3; dual specificity protein phosphatase hVH3; serine/threonine specific protein phosphatase; DUSP;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DUSP5-28378TH Recombinant Human DUSP5 Wheat Germ N/A 99 amino acids
Human DUSP5-330H Recombinant Human DUSP5 Protein, His-tagged E.coli His
Human DUSP5-2943H Recombinant Human DUSP5 Protein, GST-tagged Wheat Germ GST
Human DUSP5-6772HCL Recombinant Human DUSP5 293 Cell Lysate HEK293 N/A
Human DUSP5-382H Recombinant Human DUSP5 Protein, His-tagged E.coli His Met1~Glu135
Human DUSP5-4110HF Recombinant Full Length Human DUSP5 Protein, GST-tagged In Vitro Cell Free System GST 384 amino acids
Mouse Dusp5-383M Recombinant Mouse Dusp5 Protein, His-tagged E.coli His Met1~Gln135
Rat DUSP5-1977R Recombinant Rat DUSP5 Protein Mammalian Cell His
Rat DUSP5-1636R Recombinant Rat DUSP5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DUSP5-1636R-B Recombinant Rat DUSP5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DUSP5-11845Z Recombinant Zebrafish DUSP5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DUSP5 Related Articles

DUSP5 involved in several pathways and played different roles in them. We selected most pathways DUSP5 participated on our site, such as ARMS-mediated activation, ATF-2 transcription factor network, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationSPTB;EGF;CSF2RA;EGFR;KBTBD7;IL17RD;SPRED2;PSMA8;PAQR3B
ATF-2 transcription factor networkATF2;JUN;CDK4;POU2F1;KCNA3;DUSP10;JUNB;RUVBL2;JUND
Axon guidanceCDK5;Unc5b;LAMTOR2;PAK6;DNM1;EFNA4;SCN2B;EPHA4A;SDCBP
Cytokine Signaling in Immune systemMARK3;PEA15;RASGEF1A;UBE2V1;GBP6;JAK1;IFITM3;IRF9;CSF2
DAP12 interactionsLCP2A;HBEGF;AGO2;AGO1;DAB2IPB;PRKAR1AA;CLEC5A;AHCYL1;PEA15A
DAP12 signalingIL17RD;THEM4;NRG3;DUSP2;AGO2;LAMTOR2;FRS2A;WDR83;AGO1
Developmental BiologyCDK19;EPHB4A;DPYSL5A;MED20;FOXH1;DUSP5;SCN9A;PCSK6;PEBP1
Direct p53 effectorsBCL2L14;CTSD;FOXA1;DDX5;FDXR;PCBP4;TADA2B;DGCR8;TRIAP1

DUSP5 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP5 itself. We selected most functions DUSP5 had, and list some proteins which have the same functions with DUSP5. You can find most of the proteins on our site.

Function Related Protein
MAP kinase tyrosine/serine/threonine phosphatase activityCTDSPL2A;DUSP6;DUSP2;CTDSPL2B;NT5DC3;SGPP2;DUSP18;DUSP14;DUSP1
protein bindingPER3;MYH10;CIB3;CASP10;MAP3K1;RFWD2;CARKD;C21orf2;SRRT
protein tyrosine phosphatase activityMTMR3;DUSP23;PTP4A2A;DUSP6;PTPREB;DUSP19B;PTPN11A;TPTE;DUSP10
protein tyrosine/serine/threonine phosphatase activityDUSP11;DUSP26;DUSP13A;SACM1LA;PTP4A2B;DUSP22B;DUSP16;TENC1;CTDSPL2B

DUSP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP5.

DUSP5

Boeckx, C; de Beeck, KO; et al. Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins. CANCER LETTERS 354:365-377(2014).
Moon, SJ; Lim, MA; et al. Dual-Specificity Phosphatase 5 Attenuates Autoimmune Arthritis in Mice via Reciprocal Regulation of the Th17/Treg Cell Balance and Inhibition of Osteoclastogenesis. ARTHRITIS & RHEUMATOLOGY 66:3083-3095(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All DUSP5 Products

Required fields are marked with *

My Review for All DUSP5 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends