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ECI1

Official Full Name

enoyl-CoA delta isomerase 1
Overview

This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described.
Synonyms

ECI1; enoyl-CoA delta isomerase 1; DCI, dodecenoyl CoA isomerase , dodecenoyl Coenzyme A delta isomerase (3,2 trans enoyl Coenzyme A isomerase); enoyl-CoA delta isomerase 1, mitochondrial; 3; 2 trans enoyl CoA isomerase; 3,2 trans enoyl Coenzyme A isomerase; Acetylene allene isomerase; D3,D2 enoyl CoA isomerase; DCI protein; Delta(3),Delta(2) enoyl CoA isomerase; Delta3, delta2 enoyl CoA isomerase; Dodecenoyl CoA delta Isomerase; Dodecenoyl CoA isomerase; Dodecenoyl Coenzyme A delta isomerase; Dodecenoyl Coenzyme A delta isomerase (3,2 trans enoyl Coenzyme A isomerase); Dodecenoyl Coenzyme A delta isomerase 3,2 trans enoyl Coenzyme A isomerase, isoform CRA a; OTTHUMP00000159049; dodecenoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; acetylene-allene isomerase; 3,2 trans-enoyl-CoA isomerase; delta3, delta2-enoyl-CoA isomerase; 3,2 trans-enoyl-Coenzyme A isomerase; delta(3),Delta(2)-enoyl-CoA isomerase; 3,2-trans-enoyl-CoA isomerase, mitochondrial; dodecenoyl-CoA delta isomerase (3,2 trans-enoyl-CoA isomerase); dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase); DCI;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ECI1-2445H	Recombinant human ECI1, His-tagged	E.coli	His		Inquiry
Human	ECI1-298H	Recombinant Human ECI1 Protein, His-tagged	E.coli	His		Inquiry
Human	ECI1-5131H	Recombinant Human ECI1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ECI1-445HCL	Recombinant Human ECI1 cell lysate		N/A		Inquiry
Human	ECI1-1398H	Recombinant Human ECI1 Protein, His-tagged	E.coli	N-His	Ala158-Gly302	Inquiry
Human	ECI1-3751HF	Recombinant Full Length Human ECI1 Protein, GST-tagged	In Vitro Cell Free System	GST	243 amino acids	Inquiry
Mouse	ECI1-4970M	Recombinant Mouse ECI1 Protein	Mammalian Cell	His		Inquiry
Mouse	ECI1-2626M-B	Recombinant Mouse ECI1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Eci1-1400M	Recombinant Mouse Eci1 Protein, His-tagged	E.coli	N-His	Phe29-Gly289	Inquiry
Mouse	ECI1-2626M	Recombinant Mouse ECI1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Eci1-1399R	Recombinant Rat Eci1 Protein, His-tagged	E.coli	N-His	Phe29-Gly289	Inquiry
Chicken	ECI1-4968C	Recombinant Chicken ECI1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ECI1 Related Articles

ECI1 involved in several pathways and played different roles in them. We selected most pathways ECI1 participated on our site, such as Fatty Acid Beta Oxidation, Fatty acid degradation, Fatty acid, triacylglycerol, and ketone body metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ECI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Fatty Acid Beta Oxidation	DECR1;CPT1B;ECI1;CPT2;CPT1A;CRAT;CHKB;SLC25A20
Fatty acid degradation	CYP4A12A;ADH2-1;GCDHA;ACAA1;CYP4A11;PECI;ALDH9A1A.1;ACSL5;HADHA
Fatty acid, triacylglycerol, and ketone body metabolism	ACOT12;CDK8;DGAT1B;PPARGC1B;TMEM195;CDK19;ACOT13;GRHL1;MED21
Metabolism	AK7A;NOSIP;CYP2A13;ACSM1;CKM;UST;MPC1;GC;FAAH2B
Metabolism of lipids and lipoproteins	ESRRA;ANKRD1;GLTPA;APOEA;CERS3B;FABP1B.1;MED7;PLBD1;CHKA
Mitochondrial Fatty Acid Beta-Oxidation	ACAD11;ECI1;DECR1
Mitochondrial LC-Fatty Acid Beta-Oxidation	CPT2;SLC25A20;ECI1;EHHADH
fatty acid beta-oxidation

ECI1 has several biochemical functions, for example, dodecenoyl-CoA delta-isomerase activity, identical protein binding, intramolecular oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ECI1 itself. We selected most functions ECI1 had, and list some proteins which have the same functions with ECI1. You can find most of the proteins on our site.

Function	Related Protein
dodecenoyl-CoA delta-isomerase activity	PECI;EHHADH;ECI2;ECI1
identical protein binding	AIM2;HCN4;IL12B;SNCAIP;GSTM3;JMJD6;ADIPOR2;SDK2;RYR2
intramolecular oxidoreductase activity

ECI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ECI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ECI1.

MAPKAP1; POT1; ICT1

Filppula, SA; Yagi, AI; et al. Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase from rat liver - Molecular characterization. JOURNAL OF BIOLOGICAL CHEMISTRY 273:349-355(1998).

DieuaideNoubhani, M; Novikov, D; et al. Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver - Relationship between the different dehydrogenases and evidence that fatty acids and the C-27 bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins. EUROPEAN JOURNAL OF BIOCHEMISTRY 240:660-666(1996).