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EDEM1

Official Full Name

ER degradation enhancer, mannosidase alpha-like 1
Overview

ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene.
Synonyms

EDEM1; ER degradation enhancer, mannosidase alpha-like 1; ER degradation-enhancing alpha-mannosidase-like 1; EDEM; KIAA0212; OTTHUMP00000206910; OTTHUMP00000206911;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	EDEM1-3050H	Recombinant Human EDEM1 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Mouse	EDEM1-4986M	Recombinant Mouse EDEM1 Protein	Mammalian Cell	His	Inquiry
Mouse	EDEM1-2637M	Recombinant Mouse EDEM1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	EDEM1-2637M-B	Recombinant Mouse EDEM1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	EDEM1-1376R	Recombinant Rhesus monkey EDEM1 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	EDEM1-1201R-B	Recombinant Rhesus Macaque EDEM1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	EDEM1-1201R	Recombinant Rhesus Macaque EDEM1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	EDEM1-11406Z	Recombinant Zebrafish EDEM1	Mammalian Cell	His	Inquiry
Chicken	EDEM1-1295C	Recombinant Chicken EDEM1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
EDEM1 Related Articles

EDEM1 involved in several pathways and played different roles in them. We selected most pathways EDEM1 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDEM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Protein processing in endoplasmic reticulum	DNAJC1;EDEM1;UBE2G1;UBQLN2;UBE2D3;UBE2D1;EIF2AK2;CALRL2;SELS

EDEM1 has several biochemical functions, for example, NOT alpha-mannosidase activity, amylase activity, beta-6-sulfate-N-acetylglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EDEM1 itself. We selected most functions EDEM1 had, and list some proteins which have the same functions with EDEM1. You can find most of the proteins on our site.

Function	Related Protein
NOT alpha-mannosidase activity
amylase activity	EDEM1;Amy1;MAN1A;AMY2A5
beta-6-sulfate-N-acetylglucosaminidase activity	EDEM1;MAN1A
beta-glucanase activity	MAN1A;EDEM1
calcium ion binding	EFEMP2;CBLB;PCDHA10;EFCAB4B;CDH7;EML1;GUCA1B;SYTL2;CMLC1
dextrin alpha-glucosidase activity	MAN1A;EDEM1
fucosidase activity	MAN1A;EDEM1
galactosidase activity	EDEM1;MAN1A
glucan endo-1,4-beta-glucosidase activity	EDEM1;MAN1A
glucosidase activity	EDEM1;MAN1A
glycoprotein binding	SELP;AZGP1;SERPINA1A;Serpina1b;SDC1;LACRT;OS9;SERPINA1D;FBXO27
hexosaminidase activity	EDEM1;MAN1A
lytic transglycosylase activity	EDEM1;MAN1A
mannosidase activity	MAN1A;EDEM1;MAN1A1
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	EDEM2;MAN1A;MAN1A2;EDEM1;MAN1A1;MAN1C1;MAN1B1
mannosyl-oligosaccharide mannosidase activity	MAN1A;EDEM1
misfolded protein binding	SDF2L1;HSPD1;DNAJC3;TOR1A;BAG6;EDEM1;STUB1;DNAJC10;CLU
protein binding	TARBP2;HYLS1;HIST1H4F;ZNF423;RHOC;NDFIP2;APTX;UPRT;EIF4EA
starch alpha-glucosidase activity	EDEM1;MAN1A
trehalase activity	EDEM1;MAN1A

EDEM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDEM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EDEM1.

DNAJC10; P4HB; PDIA4; HSP90B1; CALR; CANX; PDIA3; PDIA6

Sokolowska, I; Pilka, ES; et al. Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells. BMC CELL BIOLOGY 16:-(2015).

Ninagawa, S; Okada, T; et al. EDEM1/2/3 are alpha 1,2-mannosidases essential for endoplasmic reticulum-associated degradation of glycoproteins. GLYCOBIOLOGY 24:1097-1097(2014).