EEF2
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Official Full Name
eukaryotic translation elongation factor 2
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Overview
eEF2 (eukaryotic translation elongation factor 2) is essential for protein synthesis. It promotes the GTP-dependent translocation during peptide chain elongation. eEF2 is phosphorylated and inhibited by eEF2 kinase (eEF2K) on Thr56. eEF2K activity is inhibited by phosphorylation by both mTOR and p70S6K. This in turn up regulates eEF2 activity and protein synthesis. Similarly, AMPK down regulates protein synthesis by inhibited the activity of both p70S6K and mTOR, through TSC2. -
Synonyms
EEF2; eukaryotic translation elongation factor 2; EF2; elongation factor 2; EEF 2; polypeptidyl tRNA translocase; polypeptidyl-tRNA translocase; EF-2; EEF-2;
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- His
- His (Fc)
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- Myc|DDK
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- Involved Pathway
- Protein Function
- Interacting Protein
- EEF2 Related Articles
- EEF2 Related Signal Pathway
EEF2 involved in several pathways and played different roles in them. We selected most pathways EEF2 participated on our site, such as AMPK signaling, AMPK signaling pathway, BDNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EEF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling | ADRa1A;INS-IGF2;SLC2A4RG;ADRA1B;CPT1B;CAMKK2;EEF2;PPARGC1B;EIF4EBP1 |
| AMPK signaling pathway | PDPK1;LEPR;AKT1S1;EEF2K;SCD5;PPP2R3C;PPP2R5C;CRTC2;INS |
| BDNF signaling pathway | EGR1;FRS3;YBX1;DPYSL2;CSNK2A1P;IGF2BP1;CDH2;DOK5;GNB2L1 |
| Disease | TCEA1;FDX1L;DERL2;DOCK2;RDBP;CYP11A1;AP2A2;LTF;TRAT1 |
| Eukaryotic Translation Elongation | EEF2;EEF1D;EEF1G;RPL35;EEF1B2;EEF1A2;EEF1A1 |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | ARSF;ATPBD4;FURINB;DPH2;PROCA;ARSI;EIF5A2;ARSH;PROZ |
| Gene Expression | ZNF671;ZNF225;EEF1A1;QTRT1;EIF2C3;ZNF529;NR2F1B;MED23;ZNF701 |
| Infectious disease | DOCK2;CPSF4;ANTXR1;EEF2;SYT2;CCDC167;APOBEC3G;AP1S1;PDCD6IP |
EEF2 has several biochemical functions, for example, GTP binding, GTPase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EEF2 itself. We selected most functions EEF2 had, and list some proteins which have the same functions with EEF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RAP1AB;RAP2AB;RAB27A;RALB;RAB42B;ARF3B;RABL2B;RHOC;ARL5B |
| GTPase activity | MTIF2;TUBD1;RAB1BA;GNG11;RAN;GPN1;GNA12;GTPBP10;RAB42A |
| poly(A) RNA binding | GTF2F1;MRPL37;NHP2;EIF2AK2;RBM28;NUDT21;C11orf68;MRPL28;CDK13 |
| protein binding | APLP2;WDR74;CLDN1;ATG4B;TXNDC12;CNST;AZIN2;ISCA2;PRMT3 |
| protein kinase binding | CD36;FGFR1OP;NIPAL1;SUFU;RHOD;CCNE1;RELA;CCNL1B;SYK |
| translation elongation factor activity | EEF1A1B;EEF1A1L2;TUFM;EEF1DA;EEF1D;EEF1B2;EIF5A2;EEF1A1;EEF1A1L1 |
EEF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EEF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EEF2.
Akt2; RAD23A; MAX; YWHAZ; NDRG1; q81y32_bacan; MLH1; argD; sppA; glk1; q5nfm0_fratt; q7chc3_yerpe; trpE; q7cit1_yerpe; cysK; ytrA; q81qg7_bacan; ssuA
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