EHHADH
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Official Full Name
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
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Overview
The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; ECHD, enoyl Coenzyme A, hydratase/3 hydroxyacyl Coenzyme A dehydrogenase; peroxisomal bifunctional enzyme; 3 hydroxyacyl CoA dehydrogenase; 3,2 trans enoyl CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; ECHD; ECHP_HUMAN; Enoyl Coenzyme A, hydratase/3 hydroxyacyl Coenzyme A dehydrogenase; L 3 hydroxyacyl CoA dehydrogenase; L bifunctional protein, peroxisomal; L PBE; LBFP; LBP; MGC120586; MS730; PBE; PBFE; Peroxisomal enoyl CoA hydratase; 3,2-trans-enoyl-CoA isomerase; peroxisomal enoyl-CoA hydratase; L-3-hydroxyacyl-CoA dehydrogenase; L-bifunctional protein, peroxisomal; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; L-PBE;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
EHHADH involved in several pathways and played different roles in them. We selected most pathways EHHADH participated on our site, such as Biosynthesis of antibiotics, Butanoate metabolism, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with EHHADH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Biosynthesis of antibiotics | DAO;DLD;DBT;ADSL;LDHAL6A;ECHS1;CS;NME6;SDS |
Butanoate metabolism | OXCT1;BDH2;OXCT2;HMGCL;GAD1B;L2HGDH;ACSM4;HADHAA;ACAT2 |
Carbon metabolism | DLAT;PGAM1B;FBP1A;GPT2L;PDHB;PC;PRPS2;GOT1;CAT |
Fatty acid degradation | ACAT1;ACSL5;ADH1C;EHHADH;ACSL4B;ACOX3;ALDH2.2;ACSBG1;GCDHB |
Fatty acid metabolism | SCD;ACSL4A;SCDB;ACSBG2;ACADS;TECRB;Scd2;ACADSB;ACAA2 |
Lysine degradation | AGXT2L2;ALDH2.1;SETDB1;EHMT1B;MLL1;ALDH7A1;HADH;COLGALT2;AADAT |
Metabolic pathways | PIGF;ITPKA;QARS;PKMA;GPIB;CYP4F14;ST3GAL6;AMY2B;PAFAH1B2 |
Mitochondrial LC-Fatty Acid Beta-Oxidation | ECI1;EHHADH;CPT2;SLC25A20 |
EHHADH has several biochemical functions, for example, 3-hydroxyacyl-CoA dehydrogenase activity, dodecenoyl-CoA delta-isomerase activity, enoyl-CoA hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EHHADH itself. We selected most functions EHHADH had, and list some proteins which have the same functions with EHHADH. You can find most of the proteins on our site.
Function | Related Protein |
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3-hydroxyacyl-CoA dehydrogenase activity | HADHAA;HADHAB;HSD17B4;HSD17B8;HSD17B10;H2-KE6;HADHA;HADH;HADHB |
dodecenoyl-CoA delta-isomerase activity | ECI2;ECI1;PECI;EHHADH |
enoyl-CoA hydratase activity | HADHB;HADHA;HADHAA;EHHADH;ECHS1;HADHAB;AUH |
enzyme binding | GSTM1;CUTA;UGT1A1;ATP6AP2;MDM2;NOS1;TSPAN17;SELS;SLC12A3 |
protein binding | INHBB;ASNS;LCORL;NR2C2AP;TSPAN15;AIDA;DSCAM;PARVG;FN1 |
receptor binding | HILPDA;PTK2B;FGF12B;IDUA;TNFSF18;ANG;RARA;CD70;PDGFRB |
EHHADH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EHHADH here. Most of them are supplied by our site. Hope this information will be useful for your research of EHHADH.
CCDC102B; NECAB2; BHLHE40; MID1; SSNA1; TRIM27; DES
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