Endog
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Official Full Name
endonuclease G
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Overview
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008] -
Synonyms
ENDOG; endonuclease G; endonuclease G, mitochondrial; endo G; mitochondrial endonuclease G;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|StrepII
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ENDOG-12448H | Recombinant Human ENDOG, His-tagged | E.coli | His | 63-297a.a. | |
Human | ENDOG-388H | Recombinant Human Endonuclease G, His-tagged, strepII-tagged | E.coli | His/StrepII | ||
Human | ENDOG-592H | Recombinant Human ENDOG protein, His & GST-tagged | E.coli | His/GST | Met1~Lys294 | |
Human | ENDOG-6602HCL | Recombinant Human ENDOG 293 Cell Lysate | HEK293 | N/A | ||
Human | ENDOG-4295HF | Recombinant Full Length Human ENDOG Protein, GST-tagged | In Vitro Cell Free System | GST | 297 amino acids | |
Human | ENDOG-696H | Recombinant Human ENDOG Protein, His-tagged | E.coli | His | Leu16~Lys290 | |
Mouse | ENDOG-5197M | Recombinant Mouse ENDOG Protein | Mammalian Cell | His | ||
Mouse | ENDOG-2788M-B | Recombinant Mouse ENDOG Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ENDOG-2788M | Recombinant Mouse ENDOG Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Endog-623R | Recombinant Rat Endonuclease G | E.coli | N/A | ||
Rat | Endog-697R | Recombinant Rat Endog Protein, His/GST-tagged | E.coli | His/GST | Met1~Lys294 | |
Zebrafish | ENDOG-2982Z | Recombinant Zebrafish ENDOG | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- Endog Related Articles
Endog involved in several pathways and played different roles in them. We selected most pathways Endog participated on our site, such as Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Endog were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Apoptosis | CFLARA;CASP3B;BID;MYC;DNM1L;IRF2;CASP6L1;YWHAQ;DFFB |
Endog has several biochemical functions, for example, deoxyribonuclease activity, endonuclease activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Endog itself. We selected most functions Endog had, and list some proteins which have the same functions with Endog. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
deoxyribonuclease activity | DNASE1L2;TATDN3;TATDN2;ENDOG;DNASE1L1;DNASE1L3;DNASE1L3L;NME1;TATDN1 |
endonuclease activity | RNASE2;RNASE6;ERN2;ZC3H12A;PNKP;ANG3;DIS3;PMS2;G3BP1 |
metal ion binding | ZRANB3;NAALAD2;ZNF167;PRMT3;ESYT1;ZFP746;MMP30;PPP4CA;ANKIB1 |
nuclease activity | SND1;CNOT6;RAG1;FANCM;REXO4;CNOT6L;ANG4;EAR4;DNASE1L3L |
nucleic acid binding | ZFP410;SFRS3A;U2AF2A;GIN1;ZFP629;ZFP821;HUG;FAM200A;ZBTB10 |
protein binding | E4F1;HOXC4;CPEB3;XAGE3;IGHMBP2;FAM53C;SSX2;KRTAP8-1;F2 |
Endog has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Endog here. Most of them are supplied by our site. Hope this information will be useful for your research of Endog.
DNAJA4; q96be0_human
- Q&As
- Reviews
Q&As (6)
Ask a questionThe structure of ENDOG includes multiple functional domains, including a hydrophobic transmembrane domain at the N-terminus, an uncoupling domain at the intermediate, and a proton pump domain at the C-terminus.
It catalyzes the electron transfer of NADH+H⁺ to the outside mitochondria via the uncoupling domain, while converting the proton electrochemical gradient of the inner mitochondrial membrane into heat energy.
ENDOG regulates mitochondrial energy metabolism and nutrient metabolism processes through uncoupling and proton pump action. For example, it can transfer electrons of NADH+H⁺ to the outside of mitochondria while converting the proton electrochemical gradient of the inner mitochondrial membrane into heat energy.
ENDOG HAS A VARIETY OF ASSOCIATIONS WITH OTHER PROTEINS. For example, it may interact with other proteins on the inner mitochondrial membrane to co-participate in mitochondrial function, and it may also interact with proteins in signal transduction pathways to participate in cell signaling.
There are differences in the expression levels of ENDOG in different tissues and cells. For example, it is expressed higher in muscle tissue and lower in brain tissue. This difference may be related to the energy requirements and metabolic characteristics of different tissues and cells.
Abnormal ENDOG levels may indicate a variety of diseases, especially tumors, neurodegenerative diseases, etc. For example, in tumors such as lung, breast, and colon cancer, expression levels of ENDOG may be abnormally elevated.
Customer Reviews (3)
Write a reviewThis protein synthesis process is efficient and reliable, reducing experimental time and cost.
ENDOG is easy to purify and manipulate, which improves the experimental efficiency.
The sensitivity and accuracy of the experiment were significantly improved by using this protein.
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