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Endog

  • Official Full Name

    endonuclease G

  • Overview

    The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]
  • Synonyms

    ENDOG; endonuclease G; endonuclease G, mitochondrial; endo G; mitochondrial endonuclease G;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|StrepII
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ENDOG-12448H Recombinant Human ENDOG, His-tagged E.coli His 63-297a.a.
Human ENDOG-388H Recombinant Human Endonuclease G, His-tagged, strepII-tagged E.coli His/StrepII
Human ENDOG-592H Recombinant Human ENDOG protein, His & GST-tagged E.coli His/GST Met1~Lys294
Human ENDOG-6602HCL Recombinant Human ENDOG 293 Cell Lysate HEK293 N/A
Human ENDOG-4295HF Recombinant Full Length Human ENDOG Protein, GST-tagged In Vitro Cell Free System GST 297 amino acids
Human ENDOG-696H Recombinant Human ENDOG Protein, His-tagged E.coli His Leu16~Lys290
Mouse ENDOG-5197M Recombinant Mouse ENDOG Protein Mammalian Cell His
Mouse ENDOG-2788M-B Recombinant Mouse ENDOG Protein Pre-coupled Magnetic Beads HEK293
Mouse ENDOG-2788M Recombinant Mouse ENDOG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Endog-623R Recombinant Rat Endonuclease G E.coli N/A
Rat Endog-697R Recombinant Rat Endog Protein, His/GST-tagged E.coli His/GST Met1~Lys294
Zebrafish ENDOG-2982Z Recombinant Zebrafish ENDOG Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Endog Related Articles

Endog involved in several pathways and played different roles in them. We selected most pathways Endog participated on our site, such as Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Endog were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisCFLARA;CASP3B;BID;MYC;DNM1L;IRF2;CASP6L1;YWHAQ;DFFB

Endog has several biochemical functions, for example, deoxyribonuclease activity, endonuclease activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Endog itself. We selected most functions Endog had, and list some proteins which have the same functions with Endog. You can find most of the proteins on our site.

Function Related Protein
deoxyribonuclease activityDNASE1L2;TATDN3;TATDN2;ENDOG;DNASE1L1;DNASE1L3;DNASE1L3L;NME1;TATDN1
endonuclease activityRNASE2;RNASE6;ERN2;ZC3H12A;PNKP;ANG3;DIS3;PMS2;G3BP1
metal ion bindingZRANB3;NAALAD2;ZNF167;PRMT3;ESYT1;ZFP746;MMP30;PPP4CA;ANKIB1
nuclease activitySND1;CNOT6;RAG1;FANCM;REXO4;CNOT6L;ANG4;EAR4;DNASE1L3L
nucleic acid bindingZFP410;SFRS3A;U2AF2A;GIN1;ZFP629;ZFP821;HUG;FAM200A;ZBTB10
protein bindingE4F1;HOXC4;CPEB3;XAGE3;IGHMBP2;FAM53C;SSX2;KRTAP8-1;F2

Endog has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Endog here. Most of them are supplied by our site. Hope this information will be useful for your research of Endog.

DNAJA4; q96be0_human

Zhang, XS; Bian, XW; et al. The Proapoptotic Protein BNIP3 Interacts with VDAC to Induce Mitochondrial Release of Endonuclease G. PLOS ONE 9:-(2014).
Zan, H; Zhang, JS; et al. Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions. MOLECULAR IMMUNOLOGY 48:610-622(2011).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the structure ENDOG? 09/17/2022

The structure of ENDOG includes multiple functional domains, including a hydrophobic transmembrane domain at the N-terminus, an uncoupling domain at the intermediate, and a proton pump domain at the C-terminus.

How is ENDOG involved in the uncoupling of the inner mitochondrial membrane? 01/25/2022

It catalyzes the electron transfer of NADH+H⁺ to the outside mitochondria via the uncoupling domain, while converting the proton electrochemical gradient of the inner mitochondrial membrane into heat energy.

How it affects energy metabolism and nutrient metabolism ENDOG? 11/14/2021

ENDOG regulates mitochondrial energy metabolism and nutrient metabolism processes through uncoupling and proton pump action. For example, it can transfer electrons of NADH+H⁺ to the outside of mitochondria while converting the proton electrochemical gradient of the inner mitochondrial membrane into heat energy.

Is it related to other ENDOG proteins? 09/03/2021

ENDOG HAS A VARIETY OF ASSOCIATIONS WITH OTHER PROTEINS. For example, it may interact with other proteins on the inner mitochondrial membrane to co-participate in mitochondrial function, and it may also interact with proteins in signal transduction pathways to participate in cell signaling.

What are the differences in the expression levels of ENDOG in different tissues and cells? 05/31/2021

There are differences in the expression levels of ENDOG in different tissues and cells. For example, it is expressed higher in muscle tissue and lower in brain tissue. This difference may be related to the energy requirements and metabolic characteristics of different tissues and cells.

What conditions might be indicated by abnormal ENDOG levels? 04/29/2021

Abnormal ENDOG levels may indicate a variety of diseases, especially tumors, neurodegenerative diseases, etc. For example, in tumors such as lung, breast, and colon cancer, expression levels of ENDOG may be abnormally elevated.

Customer Reviews (3)

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Reviews
04/24/2022

    This protein synthesis process is efficient and reliable, reducing experimental time and cost.

    12/27/2021

      ENDOG is easy to purify and manipulate, which improves the experimental efficiency.

      11/22/2021

        The sensitivity and accuracy of the experiment were significantly improved by using this protein.

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