epas1
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  • Official Full Name
  • endothelial PAS domain protein 1
  • Background
  • This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
  • Synonyms
  • EPAS1; endothelial PAS domain protein 1; endothelial PAS domain-containing protein 1; mHLF; EPAS-1; HIF2-alpha; HIF-2-alpha; Hif like protein; HIF-related factor; HIF1alpha-like factor; HIF1 alpha-like factor; HIF-1-alpha-like factor; HLF (HIF1alpha-like
Cat.#:EPAS1-3349HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EPAS1 Protein, GST-tagged
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Cat.#:EPAS1-12475HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EPAS1, GST-tagged
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Cat.#:EPAS1-150HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EPAS1 protein, His/S-tagged
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Cat.#:EPAS1-29318THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human EPAS1
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Cat.#:EPAS1-8053HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EPAS1 protein, His-tagged
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Cat.#:Epas1-151MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Epas1 protein, His/S-tagged
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Cat.#:EPAS1-5229MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EPAS1 Protein
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Cat.#:Epas1-8054MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Epas1 protein, His-tagged
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Cat.#:Epas1-152RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Epas1 protein, His/S-tagged
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Cat.#:EPAS1-2115RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EPAS1 Protein
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Cat.#:Epas1-8055RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Epas1 protein, His-tagged
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Cat.#:EPAS1-6370CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EPAS1
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Cat.#:EPAS1-6588HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EPAS1 293 Cell Lysate
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Involved Pathway

EPAS1 involved in several pathways and played different roles in them. We selected most pathways EPAS1 participated on our site, such as Pathways in cancer, Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pathways in cancer
PDGFB; TCEB2; PLCB4; RALBP1; GNG13; FADD; MECOM; PRKACG; PTCH1; WNT8B
Renal cell carcinoma
EPAS1; AKT2; PAK6; PIK3R2; RAPGEF1; RAC1; ARNT2; FH1; GAB1; SOS1

Protein Function

EPAS1 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, histone acetyltransferase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPAS1 itself. We selected most functions EPAS1 had, and list some proteins which have the same functions with EPAS1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein FOXD1; KLF7; GLYR1; ZHX2; POLM; TOP1MT; DMBX1A; NR5A1B; NOTO; POLR2L
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein TFAP2E; TAL2; ZNF131; SIM2; SOX21; ATF5; SIX1A; EPAS1B; ATF4B2; FOXO3A
Function histone acetyltransferase binding
Related Protein NR4A3; KAT2B; MTF1; TRP53; EID1; EGR1; SIRT2; TAF7; CREB1; TP53
Function protein binding
Related Protein CLK3; PPID; RIN1; LSM10; CBFA2T3; ATL1; USO1; TCTE3; MBD4; DIP2A
Function protein heterodimerization activity
Related Protein HIST1H2BH; ALG2; MEF2A; SLC3A1; MPP7; P4HB; VAPA; PDGFA; IRAK3; IKBKB
Function contributes_to sequence-specific DNA binding
Related Protein TRIM28; HDAC4; TCF3; SMAD4; PPARG; EPAS1; ARNT; HIF1A; FIGLA; HNRNPAB
Function transcription factor binding
Related Protein SRY; HEY2; BRD7; PSMC5; FOXO1; PAX6; PAX2; MAPK1; SNF8; MYBBP1A
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein NEUROD1; RFX4; SOX9; JUNB; ETV4; CREB3L1; EBF3A; OTX2; PHOX2B; ETV1

Interacting Protein

EPAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPAS1.
EIF3E; SMAD3; USP8; BBS4; EGLN1; PDK1; PIAS2