ephx2
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  • Official Full Name
  • epoxide hydrolase 2, cytoplasmic
  • Background
  • This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
  • Synonyms
  • EPHX2; epoxide hydrolase 2, cytoplasmic; epoxide hydrolase 2; epoxide hydratase; epoxide hydrolase, soluble; epoxide hydrolase 2, cytosolic; CEH; SEH
Cat.#:EPHX2-3409HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EPHX2 Protein, GST-tagged
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Cat.#:EPHX2-584HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human EPHX2 Protein, His-tagged
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Cat.#:EPHX2-638HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPHX2 Protein, His-tagged
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Cat.#:EPHX2-2124RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EPHX2 Protein
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Cat.#:EPHX2-3265CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EPHX2
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Cat.#:EPHX2-1928ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EPHX2
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Cat.#:EPHX2-6585HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EPHX2 293 Cell Lysate
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Involved Pathway

EPHX2 involved in several pathways and played different roles in them. We selected most pathways EPHX2 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPHX2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
CYP2P7; AWAT2; GPX8; PLA2G4C; PTGES3B; PLA2G2E; ALOX5B.2; DPEP1; PTGES3; PLA2G5
Metabolic pathways
SDHA; NDUFB1; UCK2; AOC1; MVDA; ENOPH1; HSD17B12; MGAT1B; HAAO; GULO
Peroxisome
NOS2A; CROT; CAT; PEX16; PEX11B; ACOX1; PXMP2; GNPAT; ABCD2; ACSL5

Protein Function

EPHX2 has several biochemical functions, for example, 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity, epoxide hydrolase activity, lipid phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EPHX2 itself. We selected most functions EPHX2 had, and list some proteins which have the same functions with EPHX2. You can find most of the proteins on our site.
Function
Related Protein
Function 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
Related Protein EPHX2
Function epoxide hydrolase activity
Related Protein LTA4H; EPHX1; EPHX3; EPHX4; EPHX2; Npepo; RNPEP
Function lipid phosphatase activity
Related Protein PTENA; LPPR5A; LPPR2A; EPHX2; LPPR5B; PPAP2CB; PTENB; PPAP2B; PPAP2C; LPPR1
Function magnesium ion binding
Related Protein SIK2; NUDT16; RPS6KA6; COMTB; CLYBL; NT5C3L; ICK; PGM5; RPS6KA2; CDC42BPA
Function phosphatase activity
Related Protein ALPI.2; DUSP11; CTDSPL2A; MTMR1A; CTDSPLA; SACM1LA; CTDSPLB; DUSP3B; PHOSPHO2; C12orf5
Function protein homodimerization activity
Related Protein TRIM37; GNB2L1; CHMP4A; PEX7; RPS19; TRIM5; PLEK; FAP; SLC26A5; MAP3K5
Function receptor binding
Related Protein TNFSF15; ACOX2; NRG4; RND1; LRP6; SERPINE2; TNFSF12; TNFSF8; CNPY3; TNFSF13
Function toxic substance binding
Related Protein AZU1; CHRNA7; EPHX2; DSG1; H2-AB1; NEFH; ASS1; A4GALT; PHAX; GUCY2C

Interacting Protein

EPHX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPHX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPHX2.
TERF1; MVP; papC; NIPSNAP3A

EPHX2 Related Articles

Ma, WJ; Sun, YH; et al. Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 94:13-19(2015).
Lindh, M; Svensson, F; et al. Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data. JOURNAL OF CHEMICAL INFORMATION AND MODELING 55:343-353(2015).