erbb4
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  • Official Full Name
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
  • Background
  • c-erbB-4 is the fourth member of class 1 receptor kinase family. HER-4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDA-MB-330 and MDA-MB-361. Expression of erbB-4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
  • Synonyms
  • ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); v erb a avian erythroblastic leukemia viral oncogene homolog like 4; receptor tyrosine-protein kinase erbB-4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; HER4; p180erbB4; MGC138404
Cat.#:Erbb4-7416MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Erbb4 Protein, His tagged
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Cat.#:ERBB4-2052HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB4 Protein, Fc/His-tagged
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Cat.#:ERBB4-2116HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB4 Protein, MYC/DDK-tagged
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Cat.#:ERBB4-3450HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ERBB4 Protein, GST-tagged
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Cat.#:ERBB4-3451HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ERBB4 Protein, GST-tagged
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Cat.#:ERBB4-385HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERBB4 Protein, His-tagged
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Cat.#:Erbb4-473MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian)
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Cat.#:ERBB4-358HTag:human|IgG1|Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB4 protein, Fc-tagged
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Cat.#:ERBB4-139HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ERBB4 Protein, DDK-tagged
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Cat.#:ERBB4-140HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ERBB4 Protein, DDK-tagged
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Cat.#:ERBB4-141HTag:DDK|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB4 Protein, DDK/HIS-tagged
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Cat.#:ERBB4-216HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ERBB4, His-tagged
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Cat.#:ERBB4-233HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB4, C13&N15-labeled
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Cat.#:ERBB4-26848THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ERBB4
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Cat.#:ERBB4-288HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB4, Fc-His tagged
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Cat.#:ERBB4-329HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ERBB4, GST-tagged, Active
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Cat.#:ERBB4-622HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ERBB4, His-tagged, Biotinylated
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Cat.#:ERBB4-623HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ERBB4, Fc-tagged, Biotinylated
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Cat.#:ErbB4-7282HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ErbB4, Fc tagged
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Cat.#:ErbB4-7283HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ErbB4, His tagged
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Cat.#:ERBB4-7284HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB4, His-tagged
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Cat.#:ERBB4-2134RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ERBB4 Protein
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Cat.#:ERBB4-217RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Erbb4, His tagged
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Cat.#:Erbb4-8720RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Erbb4, Fc tagged
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Cat.#:ERBB4-2237CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ERBB4
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Cat.#:ERBB4-1126HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian), GST-tagged
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Cat.#:ERBB4-1218HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian), GST-tagged
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Cat.#:ERBB4-001HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ERBB4 cell lysate
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Cat.#:ERBB4-1543HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB4 cell lysate
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Cat.#:ERBB4-1417MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ERBB4 cell lysate
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Cat.#:ERBB4-895RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat ERBB4 cell lysate
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Involved Pathway

ERBB4 involved in several pathways and played different roles in them. We selected most pathways ERBB4 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERBB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
MYCB; CAMK2D2; CDKN1BB; NCK2; PTK2; PLCG2; CBLB; AKT2; MAP2K4; PTK2AA
Calcium signaling pathway
GNAQ; PTGFR; PHKA1; PHKB; DRD1A; PTAFR; MLCK2; CAMK2D1; TNNC2; PPP3CA
Endocytosis
ARR3B; GRK1A; VPS24; VPS26BL; HLA-B; FMNL3; KITA; TRAF6; RHOAD; D6WSU116E
Proteoglycans in cancer
CAMK2B; ERBB2; CDC42; WNT2B; SMAD2; WNT5B; Casp3; ITPR1; HOXD10; ITGA5

Protein Function

ERBB4 has several biochemical functions, for example, ATP binding, epidermal growth factor receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERBB4 itself. We selected most functions ERBB4 had, and list some proteins which have the same functions with ERBB4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CDC42BPB; TRIP13; TAP2; DCLK1; NEK8; ACTR2A; FGFR4; DDR2; KATNAL2; MINK1
Function epidermal growth factor receptor binding
Related Protein RNF126; MS4A1; PLSCR1; YES1; LINGO1B; HBEGFB; EPGN; VAV2; EFEMP1; TNK2
Function protein binding
Related Protein CREB5; SYF2; C7orf42; CCNB3; CDC42; GAN; WFDC9; STAT4; SUSD2; RBP4
Function protein homodimerization activity
Related Protein TPR; PDZD7; ATPIF1; MIXL1; VWF; CUL3; CARS; GALE; IKZF4; MGLL
Function protein tyrosine kinase activity
Related Protein PDGFRB; TNK2; NTRK2B; FGFR1; HCK; KIAA1804; EPHA7; EPHB2B; Fert2; EPHB4A
Function receptor signaling protein tyrosine kinase activity
Related Protein SYK; ERBB3B; EGFRA; ERBB4; KITB; EGFR; ERBB4A; ERBB2; KIT; INSR
Function transcription regulatory region DNA binding
Related Protein PROX1; MTERFD3; CREB3L1; TRP53; XRCC5; ERBB4; ZNF174; SIX1; BASP1; FOXA3
Function transmembrane receptor protein tyrosine kinase activity
Related Protein ERBB3B; NPTNB; ROR2; TYRO3; PDGFRA; FGFR1B; IGF1RA; KITA; EPHA4A; TRIM27

Interacting Protein

ERBB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERBB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERBB4.
ERBB2; DLG4; SHC1; ERBB3; GRB2

ERBB4 Related Articles

Nevoltris, D; Lombard, B; et al. Conformational Nanobodies Reveal Tethered Epidermal Growth Factor Receptor Involved in EGFR/ErbB2 Predimers. ACS NANO 9:1388-1399(2015).
D'Souza, JW; Reddy, S; et al. Combining Anti-ERBB3 Antibodies Specific for Domain I and Domain III Enhances the Anti-Tumor Activity over the Individual Monoclonal Antibodies. PLOS ONE 9:-(2014).