ercc2
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  • Official Full Name
  • excision repair cross-complementing rodent repair deficiency, complementation group 2
  • Background
  • The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ERCC2; excision repair cross-complementing rodent repair deficiency, complementation group 2; xeroderma pigmentosum complementary group D , XPD; TFIIH basal transcription factor complex helicase XPD subunit; EM9; excision repair cross complementing rodent
Cat.#:ERCC2-3457HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ERCC2 Protein, GST-tagged
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Cat.#:ERCC2-30131THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERCC2, His-tagged
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Cat.#:ERCC2-5285MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ERCC2 Protein
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Cat.#:ERCC2-11166ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ERCC2
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Cat.#:ERCC2-6566HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ERCC2 293 Cell Lysate
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Involved Pathway

ERCC2 involved in several pathways and played different roles in them. We selected most pathways ERCC2 participated on our site, such as Basal transcription factors, Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Basal transcription factors
GTF2A1; ERCC2; TAF6; GTF2I; GTF2IRD1; TAF3; TAF5L; GTF2H5; TBPL1; TBPL2
Nucleotide excision repair
CHD1L; ZFP830; COPS2; YY1; INO80E; RPA1; CUL4A; INO80; GTF2H3-2; POLD2

Protein Function

ERCC2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, 5-3 DNA helicase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC2 itself. We selected most functions ERCC2 had, and list some proteins which have the same functions with ERCC2. You can find most of the proteins on our site.
Function
Related Protein
Function 4 iron, 4 sulfur cluster binding
Related Protein POLD1; BRIP1; NTHL1; LIAS; DPYD; POLA1; NDUFV1; REV3L; DPYDB; RTEL1
Function 5-3 DNA helicase activity
Related Protein ERCC2; DNA2; C10orf2; PEO1
Function ATP binding
Related Protein PRKD2; BMPR1AA; HSPA1L; TSSK1; PET112L; MCM3; HIPK2; NARS2; JAK1; GLUL
Function ATP-dependent DNA helicase activity
Related Protein DHX9; DDX3X; DDX11; CHD1; ERCC2; CHD4; RTEL1; BRIP1; XRCC5; RECQL
Function DNA binding
Related Protein EGR3; FOXB1B; ZBTB3; FBXO21; SETDB2; HESX1; ZBED4; MSXD; HMGB1A; WRN
Function contributes_to DNA-dependent ATPase activity
Related Protein MNAT1; RBBP4; GTF2H4; BPTF; ERCC3; ERCC2; GTF2H2; GTF2H3; GTF2H1
Function DNA-dependent ATPase activity
Related Protein DHX36; TOP2A; CHD8; DMC1; RAD51C; DDX11; SMARCA4; ERCC2; MSH6; IGHMBP2
Function contributes_to RNA polymerase II carboxy-terminal domain kinase activity
Related Protein ERCC2; ERCC3; GTF2H4; GTF2H3; MNAT1; GTF2H2; GTF2H1
Function metal ion binding
Related Protein ZFP828; RNF187; NOS2A; WDFY3; ARFGAP1; INPP5B; TERT; ZC3H12A; AOX3L1; PPM1K
Function protein C-terminus binding
Related Protein MED12; ARL6IP5; ITGB3BP; SIAH1; SDCBP; PRDX3; ITPR1; ATXN2; PDZD11; PIAS3
Function protein N-terminus binding
Related Protein SNCA; GTF2H3; RPA2; RASSF1; ALOX5AP; VPS25; SCT; SLC6A3; SYNGR3; KCNIP2
Function protein binding
Related Protein KIAA1274; SNRPA; SOCS4; NTSR1; EML2; MTF1; MYL7; MAP4K1; ELN; MRPL10
Function contributes_to protein kinase activity
Related Protein GTF2H1; GTF2H4; GTF2H3; GTF2H2; ERCC2; ERCC3

Interacting Protein

ERCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC2.
GTF2H2C; b4dyc6_human; STIP1; HSF2; HSP90AB1; NUDCD3; q96be0_human; PPP5C; AARSD1; CACYBP; EGFR; CDK7; GTF2H5

ERCC2 Related Articles

Yu, M; Bell, RH; et al. Deficiency in Nucleotide Excision Repair Family Gene Activity, Especially ERCC3, Is Associated with Non-Pigmented Hair Fiber Growth. PLOS ONE 7:-(2012).
Capella, G; Pera, G; et al. DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 37:1316-1325(2008).