Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

ERCC2

Official Full Name

excision repair cross-complementing rodent repair deficiency, complementation group 2
Overview

The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms

ERCC2; excision repair cross-complementing rodent repair deficiency, complementation group 2; xeroderma pigmentosum complementary group D , XPD; TFIIH basal transcription factor complex helicase XPD subunit; EM9; excision repair cross complementing rodent;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ERCC2-3457H	Recombinant Human ERCC2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ERCC2-30131TH	Recombinant Human ERCC2, His-tagged	E.coli	His		Inquiry
Human	ERCC2-6566HCL	Recombinant Human ERCC2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ERCC2-2397H	Recombinant Human ERCC2 Protein (Ala404-Leu637), N-His tagged	E.coli	N-His	Ala404-Leu637	Inquiry
Human	ERCC2-13H	Recombinant Human ERCC2 Protein	E.coli			Inquiry
Human	ERCC2-4548HF	Recombinant Full Length Human ERCC2 Protein, GST-tagged	In Vitro Cell Free System	GST	405 amino acids	Inquiry
Mouse	ERCC2-5285M	Recombinant Mouse ERCC2 Protein	Mammalian Cell	His		Inquiry
Mouse	ERCC2-2842M	Recombinant Mouse ERCC2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	ERCC2-2842M-B	Recombinant Mouse ERCC2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	ERCC2-11166Z	Recombinant Zebrafish ERCC2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ERCC2 Related Articles
ERCC2 Related Research Area

ERCC2 involved in several pathways and played different roles in them. We selected most pathways ERCC2 participated on our site, such as Basal transcription factors, Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Basal transcription factors	GTF2E2;GTF2E1;TAF5L;ERCC2;GTF2H4;GTF2H3;CDK7;TAF7L;GTF2F2A
Nucleotide excision repair	RPA3;MNAT1;COPS6;RPA1;ERCC8;INO80C;ZFP830;ERCC6;GTF2H4

ERCC2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, 5-3 DNA helicase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC2 itself. We selected most functions ERCC2 had, and list some proteins which have the same functions with ERCC2. You can find most of the proteins on our site.

Function	Related Protein
4 iron, 4 sulfur cluster binding	ETFDH;DPYDB;NDUFS8B;ISCU;RTEL1;REV3L;EXO5;SDHB;NUBP1
5-3 DNA helicase activity	PEO1;ERCC2;C10orf2;DNA2
ATP binding	XRCC3;ATP2B3A;PTK2AB;NME3;NEK9;NADK;KIF14;PFAS;PFTK1
ATP-dependent DNA helicase activity	CHD4;ERCC2;XRCC5;FBXO18;DHX9;G3BP1;BLM;RECQL;ERCC3
DNA binding	ZNF32;KCNIP3;CDAN1;ZBTB44;SMYD1;LIN28A;BARX2;ZNF493;TGIF2LY
contributes_to DNA-dependent ATPase activity	BPTF;GTF2H3;RBBP4;ERCC3;MNAT1;GTF2H4;GTF2H2;GTF2H1;ERCC2
DNA-dependent ATPase activity	TOP2A;RAD51L3;RAD51L1;DHX36;MSH6;DDX11;XRCC2;RAD51C;RAD51D
contributes_to RNA polymerase II carboxy-terminal domain kinase activity	GTF2H2;ERCC3;ERCC2;MNAT1;GTF2H3;GTF2H4;GTF2H1
metal ion binding	ZFP628;GLRX5;PAN3;LMX1BB;FEZF2;OBSCN;PTGS2;HELZ2;MORC2A
protein C-terminus binding	ERCC2;BLOC1S2A;IFT52;PPP1R9B;YWHAQ;PLEKHB1;CEP120;PCGF1;PEX12
protein N-terminus binding	PEX5;HAX1;MAP2K1;KCNB1;KCNIP1;RBPJ;PARP1;VWF;HESX1
protein binding	UBE2O;TOR1B;ASB7;INS;ARPIN;USP49;SCRN2;WDR25;FGF3
contributes_to protein kinase activity	GTF2H1;ERCC3;GTF2H3;ERCC2;GTF2H2;GTF2H4

ERCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC2.

GTF2H2C; b4dyc6_human; STIP1; HSF2; HSP90AB1; NUDCD3; q96be0_human; PPP5C; AARSD1; CACYBP; EGFR; CDK7; GTF2H5

Yu, M; Bell, RH; et al. Deficiency in Nucleotide Excision Repair Family Gene Activity, Especially ERCC3, Is Associated with Non-Pigmented Hair Fiber Growth. PLOS ONE 7:-(2012).

Capella, G; Pera, G; et al. DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 37:1316-1325(2008).

Nucleotide Excision Repair/Transcription Coupled Repair