ercc3
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  • Official Full Name
  • excision repair cross-complementation group 3
  • Background
  • ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ERCC3; excision repair cross-complementation group 3; XPB; BTF2; GTF2H; RAD25; TFIIH; TFIIH basal transcription factor complex helicase XPB subunit; BTF2 p89; TFIIH p89; TFIIH 89 kDa subunit; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; basic transcription factor 2 89 kDa subunit; xeroderma pigmentosum, complementation group B; xeroderma pigmentosum group B-complementing protein; TFIIH basal transcription factor complex 89 kDa subunit; excision repair cross-complementing rodent repair deficiency, complementation group 3;
Cat.#:ERCC3-3459HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ERCC3 Protein, GST-tagged
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Cat.#:ERCC3-1692HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERCC3 protein, His & T7-tagged
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Cat.#:ERCC3-2671HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERCC3, His-tagged
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Cat.#:ERCC3-30702THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ERCC3
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Cat.#:ERCC3-5286MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ERCC3 Protein
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Cat.#:ERCC3-2137RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ERCC3 Protein
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Cat.#:ERCC3-494CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ERCC3 Protein, His-tagged
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Cat.#:ERCC3-1491RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ERCC3 Protein, His-tagged
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Cat.#:ERCC3-1661CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ERCC3
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Cat.#:ERCC3-11564ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ERCC3
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Cat.#:ERCC3-6565HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ERCC3 293 Cell Lysate
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Involved Pathway

ERCC3 involved in several pathways and played different roles in them. We selected most pathways ERCC3 participated on our site, such as Basal transcription factors, Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Basal transcription factors
TAF4B; GTF2E1; CDK7; GTF2H2; TAF5; GTF2H2C_2; GTF2H4; GTF2H3; TAF7L; TAF15
Nucleotide excision repair
ERCC8; ACTR5; YY1; MNAT1; RAD23B; GTF2H4; GTF2H2C; INO80B; GTF2H1; GTF2H3

Protein Function

ERCC3 has several biochemical functions, for example, 3-5 DNA helicase activity, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC3 itself. We selected most functions ERCC3 had, and list some proteins which have the same functions with ERCC3. You can find most of the proteins on our site.
Function
Related Protein
Function 3-5 DNA helicase activity
Related Protein WRN; ERCC3; CDC45; FBXO18; GINS1
Function ATP binding
Related Protein KIF14; MCM5; NETO2; ITM2C; CUL9; DDX4; UBA2; AURKA; UBE2N; INSRB
Function ATP-dependent DNA helicase activity
Related Protein ERCC3; DDX3X; FBXO18; CHD4; XRCC5; DDX11; RTEL1; RUVBL2; CHD1; RECQL
Function ATPase activity
Related Protein VWA8; KIF6; ABCC8; EIF4A1A; ABCB6A; IDE; HAND2; DNAH6; ABCC5; MACF1
Function DNA binding
Related Protein POLR2EB; FOXG1A; EBF4; KIN; MBD3B; ZNF280D; POLR1A; ZNF74; HES7; ARHGAP35
Function contributes_to DNA-dependent ATPase activity
Related Protein ERCC3; BPTF; RBBP4; GTF2H2; GTF2H4; ERCC2; GTF2H1; GTF2H3; MNAT1
Function GTP binding
Related Protein NKIRAS1; GCH2; NUDT2; GNAZ; RAB43; SEPT3; GBP1; ARL15A; RAB5B; RAB6B
Function contributes_to RNA polymerase II carboxy-terminal domain kinase activity
Related Protein GTF2H2; GTF2H1; MNAT1; ERCC2; ERCC3; GTF2H4; GTF2H3
Function dATP binding
Related Protein ST13; HSP90AB1; ERCC3
Function damaged DNA binding
Related Protein XRCC1; ERCC1; RAD23B; POLI; POLH; RAD1; MGMT; MPG; HMGB1; POLB
Function peptide binding
Related Protein CLTA; HCRTR2; ERCC3; NUP98; ENPEP; RNPEPL1; RPS6KB1; RPS6KB2; AVPR1B; H2-Q10
Function protein C-terminus binding
Related Protein ERCC4; NEFL; CDC20; TFCP2; SAE1; DLG1; DBNL; PPP1R9B; IFT52; SP1
Function protein N-terminus binding
Related Protein STX5; PARP1; DAXX; NPAT; YWHAQ; SUV39H1; ALG2; HESX1; RND2; ACOX1
Function protein binding
Related Protein ACTL7A; CNOT7; SGOL1; NPHP1; AKAP9; AHCYL2; TGM1; TSPAN2; TMED9; GLP1R
Function contributes_to protein kinase activity
Related Protein GTF2H4; GTF2H1; ERCC2; GTF2H2; GTF2H3; ERCC3
Function transcription factor binding
Related Protein KCNA3; HIF1A; ENPP2; YWHAZ; APBB3; EPN1; SOX17; UBE2I; BRD7; PSMD10

Interacting Protein

ERCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC3.
PSMC5; Psmc5; XIAP; CEP70; SRPK2; XPC; a8k1f4_human