ercc6
Share
  • Official Full Name
  • excision repair cross-complementing rodent repair deficiency, complementation group 6
  • Background
  • This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity; there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites. Mutations in this gene result in Cockayne syndrome type B.
  • Synonyms
  • ERCC6; excision repair cross-complementing rodent repair deficiency, complementation group 6; CSB; CKN2; COFS; ARMD5; COFS1; RAD26; DNA excision repair protein ERCC-6; Rad26 homolog; Cockayne syndrome B protein; ATP-dependent helicase ERCC6; cockayne syndrome protein CSB; Cockayne syndrome group B protein; OTTHUMP00000019581; EC 3.6.4.-; EC 3.6.1
Cat.#:ERCC6-2113HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERCC6 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:ERCC6-3461HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ERCC6 Protein, GST-tagged
+Inquiry
Cat.#:ERCC6-26417THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ERCC6
+Inquiry
Cat.#:ERCC6-2672HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERCC6, His-tagged
+Inquiry

Involved Pathway

ERCC6 involved in several pathways and played different roles in them. We selected most pathways ERCC6 participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Nucleotide excision repair
POLE4; COPS6; TFPT; GTF2H1; GTF2H3; GTF2H2; POLE; COPS5; BIVM-ERCC5; ACTR5

Protein Function

ERCC6 has several biochemical functions, for example, ATP binding, DNA binding, NOT DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC6 itself. We selected most functions ERCC6 had, and list some proteins which have the same functions with ERCC6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NPR2; CDK14; MMAB; PFKFB4; PPP1CA; PRKACAB; PTK6B; HSPA4A; PI4KA; SYN1
Function DNA binding
Related Protein KLF8; BAZ2B; ZKSCAN5; ONECUT1; TCF4; STAT1A; SP100; ZNF319; ABL1; ZNF671
Function NOT DNA helicase activity
Related Protein ERCC8; DNA2; ERCC6
Function DNA-dependent ATPase activity
Related Protein RAD51C; XRCC3; DDX11; RAD51L3; TTF2; DMC1; RAD51B; ERCC6; CDK7; MSH2
Function chromatin binding
Related Protein BRD3; ADNP; ELK1; CHAF1B; RELA; TRP53; CBX7; HINFP; ARID5A; PATZ1
Function protein C-terminus binding
Related Protein NCF2; MYO1C; CTBP1; SREBF2; DLG4; PROP1; CDC20; CDK7; MKI67; HIC2
Function protein N-terminus binding
Related Protein BIRC2; GTF2H3; ERCC6; SMARCC1; YWHAQ; EIF5A; PARP1; MORF4L1; NCOA1; CSNK2A2
Function protein binding
Related Protein PKN2; RPL7A; IFNA2; RCBTB2; DDX6; HGF; PRICKLE1; IL23R; CLN5; SMC4
Function protein complex binding
Related Protein SIX2; KIF11; GNB1; IGBP1; PRKACA; AKAP5; UQCRC2; SHARPIN; UGT1A6A; TAPBPL
Function protein tyrosine kinase activator activity
Related Protein NRG1; AFAP1L2; ABI1B; GAS6; ABI1; ERCC6; PAK2; Cd24a; ABI1A; CD24

Interacting Protein

ERCC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC6.
ERCC8; POLR2A; XAB2; NFKB1; RNF11; Srp72; CBX4; NOP56; CDK2AP1; Eif3a; RPL10; HNRNPU; BAX; HDAC1; Naa50; Rpl35; Mta1