Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

ERCC6

Official Full Name

excision repair cross-complementing rodent repair deficiency, complementation group 6
Overview

This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity; there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites. Mutations in this gene result in Cockayne syndrome type B.
Synonyms

ERCC6; excision repair cross-complementing rodent repair deficiency, complementation group 6; CSB; CKN2; COFS; ARMD5; COFS1; RAD26; DNA excision repair protein ERCC-6; Rad26 homolog; Cockayne syndrome B protein; ATP-dependent helicase ERCC6; cockayne syndrome protein CSB; Cockayne syndrome group B protein; OTTHUMP00000019581; EC 3.6.4.-; EC 3.6.1;

Type

Recombinant Proteins

Species

Human
Mouse

Source

E. coli
E.coli
HEK293
HEK293T
Wheat Germ

Tag

GST
His
T7
Myc
DDK
Myc|DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ERCC6-26417TH	Recombinant Human ERCC6	Wheat Germ	N/A	100 amino acids	Inquiry
Human	ERCC6-2672H	Recombinant Human ERCC6, His-tagged	E.coli	His		Inquiry
Human	ERCC6-3461H	Recombinant Human ERCC6 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ERCC6-4775H	Recombinant Human ERCC6 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	ERCC6-2114H	Recombinant Human ERCC6 Protein, His&T7-tagged	E. coli	His&T7	Val843~Tyr1002	Inquiry
Human	ERCC6-2113H	Recombinant Human ERCC6 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Mouse	Ercc6-2855M	Recombinant Mouse Ercc6 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	Ercc6-1435M	Recombinant Mouse Ercc6 Protein, His-tagged	E.coli	N-His	Gln13-Tyr179	Inquiry

Involved Pathway
Protein Function
Interacting Protein

ERCC6 involved in several pathways and played different roles in them. We selected most pathways ERCC6 participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Nucleotide excision repair	ERCC8;ERCC4;YY1;COPS5;ACTR5;COPS7B;USP45;RFC5;COPS7A

ERCC6 has several biochemical functions, for example, ATP binding, DNA binding, NOT DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC6 itself. We selected most functions ERCC6 had, and list some proteins which have the same functions with ERCC6. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	NLRP9B;ATP2A1L;Adcy4;PARS2;GTF2F2;EPHB4B;HSPA5;CMPK2;RLN1
DNA binding	ZNF354A;OASL1;FOXQ1B;ZNF230;EBF3A;HER8.2;LHX1B;CHST13;SOX21
NOT DNA helicase activity	ERCC6;DNA2;ERCC8
DNA-dependent ATPase activity	XRCC2;TOP2A;RAD51B;DHX36;MSH2;SMARCA4;IGHMBP2;MSH3;CDK7
chromatin binding	CDC45;PYGO2;PHF21A;WDHD1;SIRT2;MSGN1;ZGLP1;TADA2B;MTA1
protein C-terminus binding	KCNK3;HRAS;CSK;TAF13;BLOC1S2A;PFKM;SLC9A3R2;NPAT;STIP1
protein N-terminus binding	EIF3E;SCFD1;NCOA1;SYNGR3;KCNQ2;NPAT;GLRX;UNC13A;PEX5
protein binding	LRP4;DRD4;BAHD1;ETS1;PRDM10;ZNF404;JAK3;PPP2R4;PTPRJ
protein complex binding	KIF11;PAFAH1B1;AP2A2;SKAP1;CPS1;HADHA;KRT8;DLG4;PTK2B
protein tyrosine kinase activator activity	ERCC6;ERBB3;ABI1;AFAP1L2;ABI1B;NRG1;PAK2;ABI3A;ABI1A

ERCC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC6.

ERCC8; POLR2A; XAB2; NFKB1; RNF11; Srp72; CBX4; NOP56; CDK2AP1; Eif3a; RPL10; HNRNPU; BAX; HDAC1; Naa50; Rpl35; Mta1