ercc6l
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  • Official Full Name
  • excision repair cross-complementing rodent repair deficiency, complementation group 6-like
  • Background
  • Plk1-interacting checkpoint helicase (PICH ) is an essential component of the spindle assembly checkpoint (Baumann, C., et al. (2007). Cell 128:101–114). This protein is an ATPase family SNF2 member, and serves as a binding partner and substrate for Plk1. When PICH is phosphorylated, it retrieves Plk1 which serves to mediate the localization of PICH. As a DNA helicase, PICH gathers at kinetochores and centromeres during prometaphase, acting as a necessary part of the spindle assembly checkpoint by recruiting MAD2 and mediating chromatin centromeric tension. Depleted PICH results in the cancellation of the spindle checkpoint causing large scale missegregation of the chromosome.
  • Synonyms
  • ERCC6L; excision repair cross-complementing rodent repair deficiency, complementation group 6-like; DNA excision repair protein ERCC-6-like; FLJ20105; PICH; PLK1 interacting checkpoint helicase; tumor antigen BJ-HCC-15; SNF2/RAD54 family protein; ATP-dependent helicase ERCC6-like; excision repair protein ERCC6-like; Plk1-interacting checkpoint helicase; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; MGC131695
Cat.#:ERCC6L-3462HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ERCC6L Protein, GST-tagged
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Cat.#:ERCC6L-5290MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ERCC6L Protein
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Cat.#:ERCC6L-5868ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ERCC6L
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Cat.#:ERCC6L-634HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ERCC6L cell lysate
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Involved Pathway

ERCC6L involved in several pathways and played different roles in them. We selected most pathways ERCC6L participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC6L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
BLZF1; GMNN; SUN1; POT1; SMAD2; TCTN2; PDS5B; SMC3; YWHAE1; OIP5
Cell Cycle, Mitotic
H3F3D; NUF2; CSNK2A1; E2F2; CENPI; DYNC1H1; NDEL1; CENPA; ENSA; MCM10
M Phase
ARPP19A; BLZF1; NCAPD2; ARPP19; CNEP1R1; SPC25; DSN1; KIF18A; CENPA; MCPH1
Mitotic Anaphase
SPC25; CENPN; CENPK; SGOL1; ZW10; KNTC1; CENPL; AHCTF1; PDS5A; ZWINT
Mitotic Metaphase and Anaphase
LEMD3; WAPAL; NDEL1B; CENPC1; MLF1IP; ERCC6L; CENPP; KNTC1; SPC25; TMPO
Mitotic Prometaphase
CENPQ; B9D2; CENPK; NDEL1; NDEL1A; PDS5B; NSL1; SKA1; CDCA5; NDEL1B
PLK1 signaling events
ECT2; BORA; NDC80; TCTN2; TPT1; PLK1S1; ERCC6L; TPX2; SPC24
RHO GTPase Effectors
NCKAP1; WASF3; NF2A; LIN7B; TAX1BP3; KDM4C; SGOL2; SKA2; SPC24; NCKIPSD

Protein Function

ERCC6L has several biochemical functions, for example, ATP binding, DNA binding, helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC6L itself. We selected most functions ERCC6L had, and list some proteins which have the same functions with ERCC6L. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF22; ALK; UPF1; IQCA1; PI4KA; UBE2D1B; XRCC2; DHX57; LACE1A; NAIP7
Function DNA binding
Related Protein ZNF697; ZNF26; SFPI1; CASZ1; POLR2J3; ZNF317; LBX2; ZNF771; SSH3; FOXA
Function helicase activity
Related Protein UPF1; MCM6L; CHD7; DDX58; MOV10B.1; HELLS; WRN; EIF4A1B; MCM8; SMARCAL1
Function protein binding
Related Protein NUFIP1; GEMIN4; AEN; TBL1X; NCBP2; KCNA3; BRMS1; BNIP3L; SCARF1; WDR25

Interacting Protein

ERCC6L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC6L here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC6L.
LMO4; PLK1; HTT; RPA3; Plk1; Ercc6l; RB1CC1; ZDHHC17; LDHA; EIF4B; BLM; TOP3A; CDC5L; RMI1