espl1
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  • Official Full Name
  • extra spindle pole bodies homolog 1
  • Background
  • Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for;chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The;first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second;step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the;final separation of sister chromatids (Sun et al., 2009 (PubMed 19345191)).
  • Synonyms
  • ESPL1; extra spindle pole bodies homolog 1 (S. cerevisiae); extra spindle poles like 1 (S. cerevisiae); separin; ESP1; KIAA0165; SEPA; separase; caspase-like protein ESPL1; extra spindle poles like 1; extra spindle poles-like 1 protein; FLJ46492
Cat.#:ESPL1-3502HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ESPL1 Protein, GST-tagged
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Cat.#:ESPL1-5323MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ESPL1 Protein
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Involved Pathway

ESPL1 involved in several pathways and played different roles in them. We selected most pathways ESPL1 participated on our site, such as Cell cycle, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ESPL1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
ODF2B; HDAC2; ZBTB17; NCAPG; TUBB4A; MCM9; CENPH; CSNK2A2; PRKDC; INCENP
Oocyte meiosis
YWHAG; MAPK12B; PPP2R5D; PPP2R5A; CPEB3; PRKACAA; ANAPC11; REC8; CPEB1B; PPP3CCA

Protein Function

ESPL1 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ESPL1 itself. We selected most functions ESPL1 had, and list some proteins which have the same functions with ESPL1. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activity
Related Protein USP16; FAM49BA; CTSLL; ATG4C; ESPL1; USP28; CASP1; CTSS; CTSL.1; CASP10
Function cysteine-type peptidase activity
Related Protein CASP6L1; ESPL1; CASPA; CASPBL; ALG13; CAPN8; ATG4B; PGPEP1; CTSSA; CTSBB
Function hydrolase activity
Related Protein ACTG2; SPO11; FAM108A; HDAC7; NUDT4A; YDJC; PSMC1B; DAGLB; USP43A; NT5C3L
Function peptidase activity
Related Protein TMPRSS12; C6AST3; Reln; BACE1; STAMBPA; CAPN11; KLK1B8; CPD; TMPRSS11D; DUB1

Interacting Protein

ESPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ESPL1.
PTTG1; CDK1; CCNB1; C1QBP; ESPL1; BDP1; KIRREL; IMP4; PML; LONP1; MECP2; VAV2; GTF2I; ZMYM4; EFTUD1; DNAAF5; MB21D1; DOT1L; MMS19

ESPL1 Related Articles

Mukherjee, M; Ge, G; et al. MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER alpha)-positive mammary adenocarcinomas. ONCOGENE 33:5511-5522(2014).
Ansari, M; Poke, G; et al. Genetic heterogeneity in Cornelia de Lange syndrome (CdLS) and CdLS-like phenotypes with observed and predicted levels of mosaicism. JOURNAL OF MEDICAL GENETICS 51:659-668(2014).