Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

ESRP1

Official Full Name

epithelial splicing regulatory protein 1
Overview

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Synonyms

ESRP1; epithelial splicing regulatory protein 1; RNA-binding protein 35A; RNA binding motif protein 35A; RNA-binding motif protein 35A; Rbm35a; BC031468; A630065D16; RP23-322G9.1; 2210008M09Rik; MGC25805; Esrp1; epithelial splicing regulatory protein 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Insect Cell
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ESRP1-12559H	Recombinant Human ESRP1, His-tagged	E.coli	His	27-226a.a.	$319 / 25ug
Human	ESRP1-6538HCL	Recombinant Human ESRP1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ESRP1-2465H	Recombinant Human ESRP1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	ESRP1-587H	Recombinant Human ESRP1 Protein (Met1-Ile681), His-tagged	Insect Cell	His	Met1-Ile681	Inquiry
Mouse	Esrp1-2872M	Recombinant Mouse Esrp1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	ESRP1-2153R	Recombinant Rat ESRP1 Protein	Mammalian Cell	His		Inquiry
Rat	ESRP1-1810R	Recombinant Rat ESRP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	ESRP1-1810R-B	Recombinant Rat ESRP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	ESRP1-5073Z	Recombinant Zebrafish ESRP1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ESRP1 Related Articles

ESRP1 involved in several pathways and played different roles in them. We selected most pathways ESRP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ESRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

ESRP1 has several biochemical functions, for example, mRNA binding, nucleotide binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ESRP1 itself. We selected most functions ESRP1 had, and list some proteins which have the same functions with ESRP1. You can find most of the proteins on our site.

Function	Related Protein
mRNA binding	CSTF2T;PAIP2;G3BP1;CELF1;AGO2;PIWIL2;TRA2B;SSB;PARK7
nucleotide binding	CHD9;PAK2A;CPEB1B;WEE2;DAZL;POLE;NADKD1;GNA12A;TARDBPL
protein binding	ARMC1;PICK1;GOSR2;HSP90B1;ABTB1;MPP1;TTBK2;HMG20B;USP19

ESRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ESRP1.

ATXN1

Marzese, DM; Liu, M; et al. Brain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome. PIGMENT CELL & MELANOMA RESEARCH 28:-(2015).

Ueda, J; Matsuda, Y; et al. Epithelial splicing regulatory protein 1 is a favorable prognostic factor in pancreatic cancer that attenuates pancreatic metastases. ONCOGENE 33:4485-4495(2014).