Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

EWSR1

  • Official Full Name

    Ewing sarcoma breakpoint region 1

  • Overview

    This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
  • Synonyms

    EWSR1; Ewing sarcoma breakpoint region 1; RNA-binding protein EWS; EWS; Ewings sarcoma EWS-Fli1 (type 1) oncogene; bK984G1.4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EWSR1-3553H Recombinant Human EWSR1 Protein, GST-tagged Wheat Germ GST
Human EWSR1-28336TH Recombinant Human EWSR1 Wheat Germ N/A 96 amino acids
Human EWSR1-6514HCL Recombinant Human EWSR1 293 Cell Lysate HEK293 N/A
Human EWSR1-05H Active Recombinant Human EWSR1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human EWSR1-876H Recombinant Human EWSR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EWSR1-67HFL Active Recombinant Full Length Human EWSR1 Protein, C-Flag-tagged Mammalian cells Flag
Human EWSR1-876H-B Recombinant Human EWSR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse EWSR1-5364M Recombinant Mouse EWSR1 Protein Mammalian Cell His
Mouse EWSR1-2890M-B Recombinant Mouse EWSR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ewsr1-985M Recombinant Mouse Ewsr1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse EWSR1-2890M Recombinant Mouse EWSR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey EWSR1-500C Recombinant Cynomolgus EWSR1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey EWSR1-245C Recombinant Cynomolgus Monkey EWSR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey EWSR1-245C-B Recombinant Cynomolgus Monkey EWSR1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EWSR1-1513R Recombinant Rhesus monkey EWSR1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque EWSR1-1338R-B Recombinant Rhesus Macaque EWSR1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EWSR1-1338R Recombinant Rhesus Macaque EWSR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken EWSR1-3331C Recombinant Chicken EWSR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EWSR1 Related Articles

EWSR1 involved in several pathways and played different roles in them. We selected most pathways EWSR1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with EWSR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Transcriptional misregulation in cancerNGFR;MEIS1;MAX;TLX1;EWSR1;LRP2BP;CDK14;HIST1H3D;TMPRSS2

EWSR1 has several biochemical functions, for example, RNA binding, calmodulin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EWSR1 itself. We selected most functions EWSR1 had, and list some proteins which have the same functions with EWSR1. You can find most of the proteins on our site.

Function Related Protein
RNA bindingRPL7A;RPUSD1;AGFG1A;PABPC1L;ZFP36L3;CELF1;NCBP1;PAPOLG;RNASEL4
calmodulin bindingEPB41;PHKA1;SPATA17;CNGA2;STRN4;GAP43;GM101;DCX;PPP3CA
identical protein bindingUSP2;BRI3;VIM;SHMT2;C1QTNF2;DNMT3A;KHDC1B;IK;COL18A1
nucleotide bindingRBM42;KIF20B;NSFA;DYRK1AA;CNOT4B;SBK3;HNRNPA0L;SRSF2B;GTF2F2A
poly(A) RNA bindingMRPL10;PARN;STXBP1;ADARB1;DDX56;HSPA9;PCBP4;SRPK2;PCBP2
protein bindingNACC2;ROCK2;ABT1;OXR1;CASP14;IL5RA;SDHB;C6orf108;TRPC2
zinc ion bindingNR2F5;TP53;TRIM17;TRIM35-22;MORC3;CRIP3;PPARA;XAF1;KMT2A

EWSR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EWSR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EWSR1.

MAPK1IP1L; PLSCR1; RASSF1; SEC24D; SEC24A; TRAF2

Soon, GST; Petersson, F; et al. Beware of immunohistochemistry - report of a cytokeratin-, desmin- and INI-1-negative pelvic desmoplastic small round cell tumor in a 51 year old woman. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8:973-982(2015).
Shibuya, R; Matsuyama, A; et al. The combination of CD99 and NKX2.2, a transcriptional target of EWSR1-FLI1, is highly specific for the diagnosis of Ewing sarcoma. VIRCHOWS ARCHIV 465:599-605(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All EWSR1 Products

Required fields are marked with *

My Review for All EWSR1 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends