exoc4
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  • Official Full Name
  • exocyst complex component 4
  • Background
  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Synonyms
  • EXOC4; exocyst complex component 4; SEC8 like 1 (S. cerevisiae) , SEC8L1; KIAA1699; MGC27170; REC8; SEC8; Sec8p; dSec8; EXOC 4; EXOC4_HUMAN; Exocyst complex component Sec8; REC 8; rSec 8; Sec 8; Sec 8p; SEC8 like 1; SEC8 protein; Sec8L1; SEC8-like 1
Cat.#:EXOC4-137HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EXOC4 Protein, HIS-tagged
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Cat.#:EXOC4-5373MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EXOC4 Protein
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Cat.#:EXOC4-2167RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EXOC4 Protein
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Cat.#:EXOC4-4261CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EXOC4
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Cat.#:EXOC4-3256ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EXOC4
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Cat.#:EXOC4-6510HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EXOC4 293 Cell Lysate
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Cat.#:EXOC4-6511HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EXOC4 293 Cell Lysate
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Involved Pathway

EXOC4 involved in several pathways and played different roles in them. We selected most pathways EXOC4 participated on our site, such as Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Tight junction
CLDN9; MYH9A; RHOAA; MYL9A; PRKCB; ACTN4; PPP2CB; GNAI1; VMHC; RHOA

Protein Function

EXOC4 has several biochemical functions, for example, PDZ domain binding, Ral GTPase binding, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOC4 itself. We selected most functions EXOC4 had, and list some proteins which have the same functions with EXOC4. You can find most of the proteins on our site.
Function
Related Protein
Function PDZ domain binding
Related Protein SLC9A3R1; ARHGEF16; SRR; FZD8; LNX2; SDC2; SNTA1; LIN7B; ATP2B4; SLC22A5
Function Ral GTPase binding
Related Protein FLNA; PIH1D2; LSM2; RAB34; RALBP1; MYO1C; PRKCH; EXOC8; EXOC5; RNF41
Function protein N-terminus binding
Related Protein CHMP6; APTX; ZWINT; ERCC5; TGFB1; SERPINB1A; SMARCC1; TARBP2; RBPJ; SLC6A3
Function protein binding
Related Protein AP3M1; TACSTD2; GBF1; ARHGAP5; MARVELD3; CCBE1; EIF4EBP3; PRTFDC1; THBS2; TEX19.1

Interacting Protein

EXOC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOC4.
SPAG9; BIRC6; LAPTM4B; EGFR; nef; WASH1; MYC; BECN1; NFKBIB; Poc1b; Atg5; DTNBP1; EXOC1

EXOC4 Related Articles

Zuo, XF; Zhang, J; et al. Exo70 interacts with the Arp2/3 complex and regulates cell migration. NATURE CELL BIOLOGY 8:1383-U38(2006).