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EXOSC6

Official Full Name

exosome component 6
Overview

This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.
Synonyms

EXOSC6; exosome component 6; exosome complex component MTR3; EAP4; hMtr3p; MTR3; Mtr3 (mRNA transport regulator 3) homolog (yeast); Mtr3p; p11; hMtr3; homolog of yeast mRNA transport regulator 3; Mtr3 (mRNA transport regulator 3)-homolog; exosome complex exonuclease MTR3; mRNA transport regulator 3 homolog;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	EXOSC6-3577H	Recombinant Human EXOSC6 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Mouse	EXOSC6-5386M	Recombinant Mouse EXOSC6 Protein	Mammalian Cell	His	Inquiry
Mouse	EXOSC6-2904M-B	Recombinant Mouse EXOSC6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	EXOSC6-2904M	Recombinant Mouse EXOSC6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	EXOSC6-2689Z	Recombinant Zebrafish EXOSC6	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

EXOSC6 involved in several pathways and played different roles in them. We selected most pathways EXOSC6 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOSC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
RNA degradation	EXOSC7;EXOSC10;DDX6;BTG4;WDR61;LSM8;MPHOSPH6;LSM7;LSM5

EXOSC6 has several biochemical functions, for example, RNA binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOSC6 itself. We selected most functions EXOSC6 had, and list some proteins which have the same functions with EXOSC6. You can find most of the proteins on our site.

Function	Related Protein
RNA binding	HNRNPL;EXOSC3;HNRNPC;HNRNPUL1;CWC15;PTBP2B;SARS;ADARB2;RPS14
poly(A) RNA binding	ZFML;ATXN2L;HELZ;RNPS1;KHSRP;PRAC;RPS26;MRPS14;PUS7

EXOSC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOSC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOSC6.

Ywhah; Nanog; Aicda