egf
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  • Official Full Name
  • epidermal growth factor
  • Background
  • This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
  • Synonyms
  • Beta urogastrone; EGF; EGF-HUMAN; Epidermal Growth Factor; HOMG4; OTTHUMP00000219721; OTTHUMP00000219722; Pro epidermal growth factor; URG; Urogastrone
Cat.#:EGF-333HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human EGF Protein (Asn 971 - Arg 1023)
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Cat.#:EGF-362CTag:His
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine EGF Protein, His-tagged
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Cat.#:EGF-407HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human EGF Protein (Asn971-Arg1023)
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Cat.#:EGF-1379HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGF Protein, MYC/DDK-tagged
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Cat.#:EGF-3112HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGF Protein
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Cat.#:EGF-3113HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EGF Protein, GST-tagged
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Cat.#:EGF-4366CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine EGF Protein
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Cat.#:EGF-4412CTag:
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken EGF Protein
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Cat.#:EGF-4362STag:
Source (Host):YeastSpecies:Swine
Product nameRecombinant Swine EGF Protein
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Cat.#:EGF-4411FTag:
Source (Host):YeastSpecies:Feline
Product nameRecombinant Feline EGF Protein
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Cat.#:EGF-556HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Epidermal Growth Factor
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Cat.#:Egf-557MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Epidermal Growth Factor
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Cat.#:EGF-166HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Epidermal Growth Factor 21-Leu
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Cat.#:EGF-479HTag:Met
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGF, Met
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Cat.#:Egf-05HTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Murine Epidermal Growth Factor
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Cat.#:EGF-023HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human EGF Protein
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Cat.#:EGF-08HTag:
Source (Host):Rice GrainSpecies:Human
Product nameRecombinant Human EGF protein
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Cat.#:EGF-12320HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGF, GST-tagged
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Cat.#:EGF-1549HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human EGF, Active, His-tagged
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Cat.#:EGF-18HTag:His
Source (Host):Barley grain (Hordeum vulgare)Species:Human
Product nameRecombinant Human EGF, His-tagged
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Cat.#:EGF-201HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGF, Fc tagged
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Cat.#:EGF-204HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGF protein, His/S-tagged
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Cat.#:EGF-214HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGF, StrepII-tagged
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Cat.#:EGF-232HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human EGF, Fc-tagged
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Cat.#:EGF-2812HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGF protein, His-tagged
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Cat.#:EGF-2813HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGF protein, His-tagged
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Cat.#:EGF-470HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human EGF, His-tagged
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Cat.#:EGF-545HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Mouse Epidermal Growth Factor, MIgG2a Fc-tagged
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Cat.#:EGF-546HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Mouse Epidermal Growth Factor, HIgG1 Fc-tagged, mutant
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Cat.#:EGF-547HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Mouse Epidermal Growth Factor, HIgG1 Fc-tagged
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Cat.#:EGF-550HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human EGF, MIgG2a Fc-tagged
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Cat.#:EGF-551HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human EGF, HIgG1 Fc-tagged
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Cat.#:EGF-6HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Epidermal Growth Factor
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Cat.#:EGF-9HTag:N/A
Source (Host):Hordeum vulgareSpecies:Human
Product nameRecombinant human EGF
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Cat.#:EGF-261MTag:FC/His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Egf, None tagged
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Cat.#:Egf-2814MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Egf protein, His & GST-tagged
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Cat.#:EGF-306MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Egf, Gly & Pro tagged
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Cat.#:EGF-316MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse EGF, MIgG2a Fc-tagged
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Cat.#:EGF-561MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Epidermal Growth Factor, MIgG2a Fc-tagged, mutant
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Cat.#:Egf-631MTag:Met
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Egf
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Cat.#:Egf-868MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Egf, Fc tagged
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Cat.#:Egf-873MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Egf Protein, His-tagged
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Cat.#:Egf -636RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Egf protein
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Cat.#:EGF-2026RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EGF Protein
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Cat.#:Egf-2816RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Egf protein, His & GST-tagged
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Cat.#:Egf-550RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Egf
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Cat.#:Egf-636RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Egf
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Cat.#:EGF-2809DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog EGF protein, His-tagged
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Cat.#:EGF-2810DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog EGF protein, His-tagged
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Cat.#:EGF-2811DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog EGF protein, His-tagged
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Cat.#:EGF-1079CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EGF
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Cat.#:EGF-11750ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EGF
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Cat.#:EGF-2815PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig EGF protein, His-tagged
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Cat.#:EGF-020ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGF (971-1023aa), Met tagged
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Cat.#:Egf-038ETag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Egf (977-1029aa), Met tagged
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Cat.#:EGF-632HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Epidermal Growth Factor
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Cat.#:EGF-866MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Epidermal Growth Factor, His-tagged
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Cat.#:Egf-460RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Epidermal Growth Factor
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Cat.#:EGF-23HTag:
Source (Host):Male urineSpecies:Human
Product nameNative Human EGF protein
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Cat.#:EGF-26462THTag:
Source (Host):Species:Human
Product nameNative Human EGF
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Cat.#:Egf -634MTag:N/A
Source (Host):Mouse Submaxillary GlandSpecies:Mouse
Product nameNative Mouse Egf protein
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Cat.#:Egf-634MTag:N/A
Source (Host):Mouse Submaxillary GlandSpecies:Mouse
Product nameNative Mouse Egf
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Cat.#:Egf -635RTag:N/A
Source (Host):Adult Male Rat Submandibular GlandsSpecies:Rat
Product nameNative Rat Egf protein
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Cat.#:Egf-635RTag:N/A
Source (Host):Adult Male Rat Submandibular Glands.Species:Rat
Product nameNative Rat Egf
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Cat.#:EGF-2716HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGF cell lysate
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Cat.#:EGF-973MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EGF cell lysate
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Cat.#:EGF-100HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human EGF Protein
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Cat.#:EGF-107HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Epidermal Growth Factor (rDNA derived) Reference standard
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Cat.#:EGF-108HTag:
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human Epidermal Growth Factor (1-52) (rDNA derived) Reference standard
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Involved Pathway

EGF involved in several pathways and played different roles in them. We selected most pathways EGF participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Arf6 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
DUSP1; JAK1; SPRED2; FGF18B; DUSP5; FRS2; FGF8B; CNKSR1; SPTA1; MARK3
Adaptive Immune System
RNF138; IFI30; CREB1B; RAP1GAP2B; LRSAM1; ACTR1B; AMICA1; KLRG1; CD200R2; RBCK1
Arf6 signaling events
EPHA2; USP6; ADAP1; ARAP2; IPCEF1; FBXO8; EGFR; EGF; ADRB2; AGTR1
Axon guidance
EPHB6; COL4A3; GPC1A; DPYSL5B; SEMA4C; ROBO3; EFNB3B; TRPC3; ROBO2; KLB
Bladder cancer
MAP2K2; MYC; E2F2; RPS6KA5; DAPK1; TYMP; BRAF; FGFR3; EGF; IL-8
Ceramide signaling pathway
CRADD; CTSD; EGF; DERL3; PAWR
Choline metabolism in cancer
SLC22A3; GPCPD1; PDPK1; PRKCB; MAP2K1; MTOR; KRAS; SOS1; SLC22A5; WAS
Constitutive Signaling by Aberrant PI3K in Cancer
HBEGF; EGF; TRAT1; FRS2; KLB; NRG3; NRG4

Protein Function

EGF has several biochemical functions, for example, calcium ion binding, epidermal growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EGF itself. We selected most functions EGF had, and list some proteins which have the same functions with EGF. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein DNASE1L3; EDEM1; PLA2G5; PLA2G2A; BMP1B; FLG2; ITSN2; KCNIP4; CAPN2; CETN1
Function epidermal growth factor receptor binding
Related Protein BTC; PLSCR1; MS4A1; EFEMP1; GRB2; SNX1; EGF; VAV2; HBEGFB; ATXN2
Function growth factor activity
Related Protein FGF10; FGF7; MANF; NRG2; FGF6A; LEFTY2; GDF3; PSPN; FGF1; IGF3
Function protein binding
Related Protein RNF139; IK; AKAP9; LGI4; SMAD2; DAB2; TRIM59; NEURL1B; HDHD3; NR1H4
Function transmembrane receptor protein tyrosine kinase activator activity
Related Protein NRG3; EFNA5; EGF; NRG1; GREM1; ANGPT4

Interacting Protein

EGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGF here. Most of them are supplied by our site. Hope this information will be useful for your research of EGF.
EGFR; S100A4; Egfr

EGF Related Articles

Ganji, R; Nabiuni, M; et al. Development of Mouse Preantral Follicle after In Vitro Culture in A Medium Containing Melatonin. CELL JOURNAL 16:546-553(2015).
Chen, XH; Liu, ZC; et al. TGF-beta and EGF induced HLA-I downregulation is associated with epithelial-mesenchymal transition (EMT) through upregulation of snail in prostate cancer cells. MOLECULAR IMMUNOLOGY 65:34-42(2015).