EGR2
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Official Full Name
early growth response 2
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Overview
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] -
Synonyms
EGR2; early growth response 2; AT591; CMT1D; CMT4E; KROX20; E3 SUMO-protein ligase EGR2; zinc finger protein Krox-20; early growth response protein 2; KROX-20, Drosophila, homolog (early growth response-2);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- EGR2 Related Articles
EGR2 involved in several pathways and played different roles in them. We selected most pathways EGR2 participated on our site, such as Adipogenesis, BDNF signaling pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adipogenesis | KLF7A;HMGA1;MIXL1;KLF6A;BMP3;GTF3AA;GADD45A;NDN;HMGA1-RS1 |
BDNF signaling pathway | EIF4E;GNB2L1;FRS3;EIF4EBP1;MAP3K2;CDKL5;DPYSL2;CDK5;CFL1 |
Calcineurin-regulated NFAT-dependent transcription in lymphocytes | IRF4;EGR4;IKZF1;EGR3;CSF2;BATF3;EGR1;DGKA;POU2F1 |
Developmental Biology | GFRA1;MYF6;DPYSL4;TCF3A;NR6A1;DUSP2;MED31;SIAH2;CHL1 |
HTLV-I infection | RELB;HRAS;XIAP;NRAS;KAT2A;MYB;PCNA;SFPI1;HLA-DRB3 |
Hepatitis B | TGFBR1;PIK3R2;CCNE1;Casp3;STAT6;Ifna11;CCNA1;PIK3R3;PIK3CD |
IL4-mediated signaling events | RETNLB;MYB;CCL26;IRF4;TFF3;NIPAL1;EGR2;IgG3;DOK2 |
Transcriptional regulation of white adipocyte differentiation | MED9;CDK19;MED29;MED18;MED19;NR2F2;EBF1;EGR2;MED22 |
EGR2 has several biochemical functions, for example, HMG box domain binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGR2 itself. We selected most functions EGR2 had, and list some proteins which have the same functions with EGR2. You can find most of the proteins on our site.
Function | Related Protein |
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HMG box domain binding | SP1;ALX4;OLIG2;POU3F3;EGR2;GATA3;HOXA3;JUN;HHEX |
RNA polymerase II activating transcription factor binding | TBX20;TBX3;NFE2L2;ATF2;TP53BP1;ISL1;SETD3;LDB1;EOMES |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | PRDM5;ATF4;MYBL1;CEBPZ;MYBL2;ESRRA;KDM6A;FOS;POU1F1 |
chromatin binding | GATA3;KLF6A;OVOL2;PHF13;ARID3C;SOX9;ARX;MITF;CHAF1B |
ligase activity | TTC3;TRIM33;BARD1;UBE2L3B;RNF14;MID1;HERC5;UBE4B;TRIM71 |
metal ion binding | DDAH1;ZFP524;MAN1A;FUZ;ABAT;PKM;PVALB7;PPM1DA;VPS29 |
protein binding | ITGB2;CTPS2;PAXIP1;ACTN4;METTL1;DPP4;BAZ1B;CCDC41;ZKSCAN5 |
transcription factor activity, sequence-specific DNA binding | TARDBP;POU5F1;SHOX;CDX2;SOX9;HOXC8;HOXB8A;FOXN2B;IRF3 |
transcription regulatory region DNA binding | HDAC1;SIX1;FOS;HOXA13;GATA3;TAF7L;IKZF4;FOXM1;OVOL2 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | SOX2;GLIS2;FLI1;POU4F2;HOXC13;ALS2CR8;KLF4;EBF1;HOXA10 |
ubiquitin protein ligase binding | TRAF4;DIO2;IKBKE;SMAD2;DBT;TP53;BAG4;TNFRSF1B;KDM4A |
EGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGR2.
NDUFS2; BPGM; ACP5; HCFC1; RPL7L1; RBM15B; HN1L; RIMKLB; MED31; Nab2
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