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ELAC2

Official Full Name

elaC homolog 2 (E. coli)
Overview

The protein encoded by this gene has a C-terminal domain with tRNA 3&#8242; processing endoribonuclease activity, which catalyzes the removal of the 3 trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

ELAC2; elaC homolog 2 (E. coli); elaC (E. coli) homolog 2; zinc phosphodiesterase ELAC protein 2; FLJ10530; HPC2; tRNase Z (long form); ElaC homolog protein 2; ELC2; FLJ36693; FLJ42848; Heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z 2; Ribonuclease Z2; RNase Z 2; RNase Z2; RNZ2_HUMAN; tRNA 3 endonuclease 2; tRNase Z 2; tRNase Z2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ELAC2-12395H	Recombinant Human ELAC2, GST-tagged	E.coli	GST	86-385a.a.	$319 / 25ug
Human	ELAC2-3229H	Recombinant Human ELAC2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ELAC2-6638HCL	Recombinant Human ELAC2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ELAC2-6299H	Recombinant Human ELAC2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	ELAC2-4335HF	Recombinant Full Length Human ELAC2 Protein, GST-tagged	In Vitro Cell Free System	GST	826 amino acids	Inquiry
Mouse	Elac2-2796M	Recombinant Mouse Elac2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	ELAC2-2073R	Recombinant Rat ELAC2 Protein	Mammalian Cell	His		Inquiry
Rat	ELAC2-1730R	Recombinant Rat ELAC2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	ELAC2-1730R-B	Recombinant Rat ELAC2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	ELAC2-8126Z	Recombinant Zebrafish ELAC2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ELAC2 Related Articles

ELAC2 involved in several pathways and played different roles in them. We selected most pathways ELAC2 participated on our site, such as Gene Expression, RNA transport, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gene Expression	ZNF383;NR1D2;GATAD2A;ZNF561;ZNF334;ZNF584;CBX3A;DNMT3A;CSTF2
RNA transport	THOC3;EIF4E1C;NUP214;NUP153;SEC13;SUMO3;XPO5;TPRB;EIF3JA
tRNA processing	C22orf28;XPOT;TSEN2;C2orf49;FAM98B;TYW5;LCMT2;ALKBH8;TRDMT1
tRNA processing in the nucleus	RPP30;C2orf49;C14orf166;TSEN54;RPP14;TSEN34;POP1;RPP38;TSEN2

ELAC2 has several biochemical functions, for example, 3-tRNA processing endoribonuclease activity, metal ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELAC2 itself. We selected most functions ELAC2 had, and list some proteins which have the same functions with ELAC2. You can find most of the proteins on our site.

Function	Related Protein
3-tRNA processing endoribonuclease activity	ELAC2;ELAC1
metal ion binding	EGR2A;TRIM35-7;ADCY8;NRP2;FBXO5;ZNF562;CPSF3;KDM1B;ZSCAN23
poly(A) RNA binding	HSP90AB1;C3orf26;PPHLN1;FASTKD1;SUGP2;RPL5B;COX4I2;CPEB3;PDIA4

ELAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELAC2.

PUF60; NDUFA7; CUX1; GOLM1; ASCC2; q9wmx2-pro_0000037549; Rpl35; CAMKK1; Bag2

Cartwright, R; Mangera, A; et al. Systematic Review and Meta-analysis of Candidate Gene Association Studies of Lower Urinary Tract Symptoms in Men. EUROPEAN UROLOGY 66:752-768(2014).

Zhou, H; Zhou, M; et al. RNase Z(S1) processes Ub(L40) mRNAs and controls thermosensitive genic male sterility in rice. NATURE COMMUNICATIONS 5:-(2014).