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ELAVL1

  • Official Full Name

    ELAV like RNA binding protein 1

  • Overview

    The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3 untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]
  • Synonyms

    ELAVL1; ELAV like RNA binding protein 1; HUR; Hua; MelG; ELAV1; ELAV-like protein 1; Hu antigen R; hu-antigen R; embryonic lethal, abnormal vision, drosophila, homolog-like 1; ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ELAVL1-01H Recombinant Human ELAVL1(1-326aa), GST-tagged Wheat Germ GST
Human ELAVL1-02H Recombinant Human ELAVL1(1-100aa), GST-tagged Wheat Germ GST
Human ELAVL1-6637HCL Recombinant Human ELAVL1 293 Cell Lysate HEK293 N/A
Human ELAVL1-75HFL Active Recombinant Full Length Human ELAVL1 Protein, C-Flag-tagged Mammalian cells Flag
Human ELAVL1-145HF Recombinant Full Length Human ELAVL1 Protein, GST-tagged In Vitro Cell Free System GST 1 a.a. - 326 a.a.
Human ELAVL1-832H-B Recombinant Human ELAVL1 Protein Pre-coupled Magnetic Beads HEK293
Human ELAVL1-6668H Recombinant Human ELAVL1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ELAVL1-832H Recombinant Human ELAVL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ELAVL1-76HFL Recombinant Full Length Human ELAVL1 Protein, GST-tagged E.coli GST 1-326 aa
Mouse ELAVL1-5123M Recombinant Mouse ELAVL1 Protein Mammalian Cell His
Mouse ELAVL1-2731M-B Recombinant Mouse ELAVL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Elavl1-1198M Recombinant Mouse Elavl1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ELAVL1-2731M Recombinant Mouse ELAVL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ELAVL1-9020Z Recombinant Zebrafish ELAVL1 Mammalian Cell His
Chicken ELAVL1-6396C Recombinant Chicken ELAVL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ELAVL1 involved in several pathways and played different roles in them. We selected most pathways ELAVL1 participated on our site, such as AMPK signaling, AMPK signaling pathway, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELAVL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AMPK signalingEIF4EBP1;CPT1B;PPARGC1B;INS-IGF2;ADRa1A;CDKN1A;ELAVL1;CAMKK2;CPT1A
AMPK signaling pathwayIGF1;LEP;GYS2;CREB5;PRKAA1;PPP2R5C;PRKAG3;PPARG;SREBF1
Gene ExpressionZNF136;MBD3A;ZNF74;NRBF2;ZNF234;SURF1;MTA2;ZNF224;PRMT5
HuR (ELAVL1) binds and stabilizes mRNASETB;HUG;ANP32A;ELAVL1;SET;SETA
Regulation of mRNA stability by proteins that bind AU-rich elementsELAVL1;ZFP36L1A;KHSRP;HUG;HNRNPD;ZFP36L1;ANP32A;SETA;SET

ELAVL1 has several biochemical functions, for example, AU-rich element binding, RNA binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELAVL1 itself. We selected most functions ELAVL1 had, and list some proteins which have the same functions with ELAVL1. You can find most of the proteins on our site.

Function Related Protein
AU-rich element bindingELAVL4;NUDT21;ZFP36L1;CPSF5;ELAVL3;ZFP36;ZFP36L3;EXOSC8;EXOSC9
RNA bindingAKAP1B;HNRNPH3;SRSF1B;HNRNPAB;TIAL1;JAKMIP1;UPF3A;EXOSC7;APOBEC3G
double-stranded RNA bindingEIF2C3;VIM;OAS2;OASL1;ZFP346;HMGB1;STAU2;RNASEN;SLC3A2
mRNA 3-UTR AU-rich region bindingCPEB2;CPEB1B;ZFP36;CPEB1;CPSF1;ELAVL1;CPEB3
mRNA 3-UTR bindingRNF20;RBM4;AUH;IGF2BP3;LARP1;ELAVL4;RIMS2;ELAVL1;SERBP1
mRNA bindingNUDT21;FXR1;RPL7;PAIP2;CSTF2;RPS26L;RBM38;ZFP36;FXR2
nucleotide bindingRBM42;LTK;ARF3A;CCC2;DNM2A;PIF1;CAMK1GA;NSFB;ABT1
poly(A) RNA bindingBOP1;MRPL41;BYSL;QKI;ADARB1;CSDE1;RPS23;RRP36;RPS3
protein bindingC1orf38;NR1H4;NOTCH1;NUTF2;Artn;CRYGC;ARHGEF12;NAT10;RRAS
protein kinase bindingSFN;ZC3HC1;ERRFI1;JTB;CCNE1;CCNT2B;MAPK6;CDC42;AGAP2

ELAVL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELAVL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELAVL1.

SDCBP; q99ib8-pro_0000045602; TOP1; Smurf2; UBC; SF3A2; RBFOX2; GJB3; PTBP1; NOS3

  • Q&As
  • Reviews

Q&As (6)

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Is relationship between the ELAVL1 gene and the immune system? 04/28/2022

Studies have shown that the ELAVL1 gene may be involved in the regulation of the immune system, especially in the inflammatory response.

What is the localization of the ELAVL1 gene in cells? 01/19/2021

The protein encoded by the ELAVL1 gene is mainly located in the cytoplasm and nucleus.

What is the change in the expression level of ELAVL1 gene in tumors? 10/24/2020

In some tumors, the expression level of ELAVL1 gene may be increased or decreased, which is related to the occurrence and progression of tumors.

What is the effect of ELAVL1 gene on apoptosis? 04/21/2020

This gene may play an important role in the process of apoptosis, but its specific mechanism of action still needs further research.

How is the ELAVL1 gene involved in the differentiation of nerve cells? 02/10/2020

ELAVL1 is involved in the differentiation of nerve cells by binding to and stabilizing neuronal cell-specific microRNAs.

In which tissues and organs is the ELAVL1 gene expressed? 02/08/2020

This gene isexpressed in many tissues and organs, including the brain, heart, liver, muscles, etc.

Customer Reviews (3)

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Reviews
12/19/2022

    It is very pure and can be used with confidence.

    07/20/2021

      In enzymatic experiments, ELAVL1 was found to have high catalytic efficiency.

      06/11/2020

        In immunological experiments, it was found that ELAVL1 had good antigenicity and could induce target immune response.

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