EPAS1
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Official Full Name
endothelial PAS domain protein 1
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Overview
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. -
Synonyms
EPAS1; endothelial PAS domain protein 1; endothelial PAS domain-containing protein 1; mHLF; EPAS-1; HIF2-alpha; HIF-2-alpha; Hif like protein; HIF-related factor; HIF1alpha-like factor; HIF1 alpha-like factor; HIF-1-alpha-like factor; HLF (HIF1alpha-like;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Baculovirus-Insect cells
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His|S
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | EPAS1-8053H | Recombinant Human EPAS1 protein, His-tagged | E.coli | His | Cys339~Gln541 (Accession # Q99814) | |
Human | EPAS1-12475H | Recombinant Human EPAS1, GST-tagged | E.coli | GST | 1-350a.a. | |
Human | EPAS1-29318TH | Recombinant Human EPAS1 | Wheat Germ | N/A | 320 amino acids | |
Human | EPAS1-150H | Recombinant Human EPAS1 protein, His/S-tagged | E.coli | His/S | ||
Human | EPAS1-3349H | Recombinant Human EPAS1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | EPAS1-6588HCL | Recombinant Human EPAS1 293 Cell Lysate | HEK293 | N/A | ||
Human | EPAS1-3021H | Recombinant Human EPAS1 protein, His-tagged | E.coli | His | 521-870 aa | |
Human | EPAS1-4349HF | Recombinant Full Length Human EPAS1 Protein, GST-tagged | In Vitro Cell Free System | GST | 870 amino acids | |
Human | EPAS1-2173H | Recombinant Human EPAS1 Protein, His-tagged | E.coli | N-His | Lys26-Ile347 | |
Human | EPAS1-0330H | Recombinant Human EPAS1 Protein (Ala34-Ser392), C-His-tagged | Baculovirus-Insect cells | C-His | Ala34-Ser392 | |
Human | EPAS1-2967H | Recombinant Human EPAS1 Protein (Leu239-Asn350), N-His tagged | E.coli | N-His | Leu239-Asn350 | |
Mouse | EPAS1-5229M | Recombinant Mouse EPAS1 Protein | Mammalian Cell | His | ||
Mouse | Epas1-8054M | Recombinant Mouse Epas1 protein, His-tagged | E.coli | His | Asp21~Cys336 (Accession # P97481) | |
Mouse | Epas1-151M | Recombinant Mouse Epas1 protein, His/S-tagged | E.coli | His/S | ||
Mouse | EPAS1-2808M | Recombinant Mouse EPAS1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | EPAS1-2808M-B | Recombinant Mouse EPAS1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | Epas1-8055R | Recombinant Rat Epas1 protein, His-tagged | E.coli | His | Arg24~Glu348 (Accession # Q9JHS1) | |
Rat | Epas1-152R | Recombinant Rat Epas1 protein, His/S-tagged | E.coli | His/S | ||
Rat | EPAS1-2115R | Recombinant Rat EPAS1 Protein | Mammalian Cell | His | ||
Rat | EPAS1-1772R-B | Recombinant Rat EPAS1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | EPAS1-1772R | Recombinant Rat EPAS1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Chicken | EPAS1-6370C | Recombinant Chicken EPAS1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- EPAS1 Related Research Area
EPAS1 involved in several pathways and played different roles in them. We selected most pathways EPAS1 participated on our site, such as Pathways in cancer, Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Pathways in cancer | SFPI1;RASSF5;SMAD4;RAC1;HDAC2;PLCB2;GNB4;RXRB;TPR |
Renal cell carcinoma | HRAS;BRAF;VEGFA;ARNT2;PIK3R2;MAPK1;AKT1;SLC2A1;MAP2K2 |
EPAS1 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, histone acetyltransferase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPAS1 itself. We selected most functions EPAS1 had, and list some proteins which have the same functions with EPAS1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
DNA binding | RFX2;ZBTB24;ZNF771;GTF2F2;FOXD1L;DDX3Y;SIX1A;INSM1B;SETDB1A |
RNA polymerase II transcription factor activity, sequence-specific DNA binding | SPI1;GATA6;OVOL2;RUNX3;SOX9A;EPAS1;TFAP2D;ELF2;MITFB |
histone acetyltransferase binding | MEF2A;FOXP3;ETS1;CEBPB;GLI3;EPAS1;CREB1;TAF7;TRP53 |
protein binding | LSM8;NRXN1;RAB37;POC1B;JUN;GIMAP5;DCTPP1;IPO11;VPS36 |
protein heterodimerization activity | RARA;IKZF3;TIRAP;IL12A;SLC3A1;TAF9B;ATF6;MEF2C;TOP2A |
contributes_to sequence-specific DNA binding | HDAC4;EPAS1;NEUROD1;HIF1A;FIGLA;HNRNPAB;PPARG;TRIM28;SMAD4 |
transcription factor binding | FOXC1;MYOD1;HMGB1;PSMD4;JUNB;PURA;MAFB;HDAC2;GPX3 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PLSCR1;GATA1;DLX3;CREB3;CDX4;EGR1;EBF4;KLF15;MYC |
EPAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPAS1.
EIF3E; SMAD3; USP8; BBS4; EGLN1; PDK1; PIAS2
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