EPHX1
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Official Full Name
epoxide hydrolase 1, microsomal (xenobiotic)
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Overview
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
EPHX1; epoxide hydrolase 1, microsomal (xenobiotic); EPHX; epoxide hydrolase 1; epoxide hydratase; MEH; EPOX; HYL1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Oryctolagus cuniculus (Rabbit)
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Sus scrofa (Pig)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect cell
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- MYC
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
EPHX1 involved in several pathways and played different roles in them. We selected most pathways EPHX1 participated on our site, such as Metabolism of xenobiotics by cytochrome P, Bile secretion, Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPHX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of xenobiotics by cytochrome P | UGT1A1;CBR1L;UGT1A4;MGST1.1;UGT2A1;SULT2A1;MGST2;UGT2A3;UGT1AB |
| Bile secretion | ATP1B2;AQP1;ATP1A4;ABCC2;AQP9;AQP4;EPHX1;NR0B2;SLC9A1 |
| Chemical carcinogenesis | EPHX1;UGT1A4;CYP3A7-CYP3AP1;GSTP2;PTGS2;UGT1A9;GSTA1;CYP2C19;ADH2-2 |
EPHX1 has several biochemical functions, for example, cis-stilbene-oxide hydrolase activity, epoxide hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EPHX1 itself. We selected most functions EPHX1 had, and list some proteins which have the same functions with EPHX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cis-stilbene-oxide hydrolase activity | |
| epoxide hydrolase activity | RNPEP;EPHX4;EPHX3;Npepo;EPHX1;EPHX2;LTA4H |
EPHX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPHX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPHX1.
- Q&As
- Reviews
Q&As (7)
Ask a questionGenetic variations in EPHX1 can influence drug metabolism, affecting individual responses to medications.
EPHX1 modulates inflammatory processes, potentially impacting the development and severity of inflammatory conditions.
EPHX1 is involved in metabolizing xenobiotics and endogenous compounds, playing a role in chemical detoxification.
EPHX1 impacts the development of respiratory diseases by modulating the metabolism of lung irritants.
Changes in EPHX1 expression or function can alter disease risk, particularly in chronic conditions like cancer and cardiovascular diseases.
EPHX1 helps detoxify environmental pollutants and carcinogens, reducing their harmful effects.
EPHX1 processes EETs, important for cardiovascular function and blood pressure regulation.
Customer Reviews (3)
Write a reviewEfficient protein purification, delivers high yield and purity consistently.
Dependable expertise in protein engineering, unmatched quality.
Invaluable protein-protein interaction assays, integral to our research.
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