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ESR1

  • Official Full Name

    estrogen receptor 1

  • Overview

    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
  • Synonyms

    ESR1; estrogen receptor 1; ER; ESR; Era; ESRA; ESTRR; NR3A1; estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; nuclear receptor subfamily 3 group A member 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Insect cells
  • Insects cell
  • Mammalian Cell
  • Mammalian cells
  • S.frugiperda
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • FLAG
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ESR1-1033H Active Recombinant Human Estrogen Receptor 1 Sf9 Insect Cell N/A
Human ESR1-8487H Active Recombinant Human ESR1, His-tagged Sf21 Insect Cell His
Human ESR1-12557H Recombinant Human ESR1, GST-tagged E.coli GST 65-280a.a.
Human ESR1-24H Recombinant Human ESR1 Protein Insects cell N/A
Human ESR1-28402TH Recombinant Human ESR1 protein, His-tagged E.coli His Ser178~Met438
Human ESR1-27977TH Recombinant Human ESR1, His-tagged Insect Cell His
Human ESR1-28401TH Recombinant Human ESR1 protein E.coli N/A
Human ESR1-784H Recombinant Human ESR1 Protein, His-tagged E.coli His
Human ESR1-121H Recombinant Human ESR1, GST-tagged Sf9 Insect Cell GST
Human ESR1-356H Recombinant Human ESR1 protein, His/MBP-tagged E.coli His/MBP 395-595 aa
Human ESR1-117H Recombinant Human ESR1, His-tagged E.coli N/A
Human ESR1-3504H Recombinant Human ESR1 Protein, GST-tagged Wheat Germ GST
Human ESR1-227H Recombinant Human ESR1, StrepII-tagged Human Cell Strep II 2-181, 180 a.a.
Human ESR1-102H Recombinant Human Estrogen alpha receptor LBD/Hsp90 complex, GST-tagged Sf9 Insect Cell GST
Human ESR1-116H Recombinant Human Estrogen Receptor 1 E.coli N/A
Human ESR1-2639H Recombinant Human Estrogen Receptor 1 S.frugiperda N/A
Human ESR1-6540HCL Recombinant Human ESR1 293 Cell Lysate HEK293 N/A
Human ESR1-118H Recombinant Human ESR1 protein, His-tagged E.coli His Met297-Ser554
Human ESR1-1250H Recombinant Human ESR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ESR1-2299H Recombinant Human ESR1 Protein (Met1-Val595), C-His tagged Mammalian cells C-His Met1-Val595
Human ESR1-014H Recombinant Human ESR1 Protein E.coli
Human ESR1-18H Recombinant Human ESR1 Protein, His-tagged E.coli His
Human ESR1-4217H Recombinant Human ESR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ESR1-2300H Recombinant Human ESR1 Protein (Met1-Gln116), N-His tagged E.coli N-His Met1-Gln116
Human ESR1-2416H Recombinant Human ESR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ESR1-38HFL Active Recombinant Full Length Human ESR1 Protein, C-Flag-tagged Mammalian cells Flag
Human ESR1-17H Recombinant Human ESR1 Protein, His-tagged E.coli His
Human ESR1-2301H Recombinant Human ESR1 Protein (Met297-Ser554), His tagged E.coli His Met297-Ser554
Human ESR1-04H Recombinant Human ESR1 Protein, His-tagged E.coli His
Human ESR1-1390H Recombinant Human ESR1 Protein (10-595 aa), His-tagged Yeast His 10-595 aa
Human ESR1-14H Recombinant Human ESR1 Protein E.coli
Human ESR1-01H Recombinant Human Estrogen Receptor 1, His-tagged E. coli His
Human ESR1-4720HF Recombinant Full Length Human ESR1 Protein, GST-tagged In Vitro Cell Free System GST 595 amino acids
Human ESR1-02H Recombinant Human ESR1 Protein, His-tagged E. coli His
Human ESR1-868H Recombinant Human ESR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ESR1-868H-B Recombinant Human ESR1 Protein Pre-coupled Magnetic Beads HEK293
Human ESR1-2534H Recombinant Human ESR1 protein(191-270 aa), C-His-tagged E. coli C-His 191-270 aa
Human ESR1-13HFL Recombinant Human ESR1 Protein, Full Length, N-FLAG tagged Insect cells N-FLAG Full Length
Mouse Esr1-1438M Recombinant Mouse Esr1 protein, His & GST-tagged E.coli His/GST Ile233~Leu483
Mouse Esr1-977M Recombinant Mouse Esr1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat ESR1-2151R Recombinant Rat ESR1 Protein Mammalian Cell His
Rat Esr1-1439R Recombinant Rat Esr1 protein, His & GST-tagged E.coli His/GST Arg248~Leu484 (Accession # P06211)
Rat ESR1-1808R-B Recombinant Rat ESR1 Protein Pre-coupled Magnetic Beads HEK293
Rat ESR1-1808R Recombinant Rat ESR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ESR1-9425Z Recombinant Zebrafish ESR1 Mammalian Cell His
Chicken ESR1-6738C Recombinant Chicken ESR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ESR1 Related Articles

ESR1 involved in several pathways and played different roles in them. We selected most pathways ESR1 participated on our site, such as Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ESR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Estrogen signaling pathwaySHC1;PLCB4;SHC4;CREB3L2;CREB3L3;GRM1;PIK3CB;GPR30;KCNJ5
Prolactin signaling pathwaySOCS7;MAPK9;STAT3;INS1;LHB;ESR1;CSH;SHC1;STAT5B
Thyroid hormone signaling pathwayNOTCH3;MAP2K1;ATP1A4;PLCG1;PIK3R1;RHEB;PIK3CG;THRB;MDM2
Endocrine and other factor-regulated calcium reabsorptionFXYD2;ATP2B1;ATP1A1;KLK1B1;PRKCA;ATP1A3;KLK1B26;PLCB3;KL
Proteoglycans in cancerFGF2;PPP1R12B;HIF1A;IGF1;PIK3R1;ERBB3;MTOR;PTCH1;WNT3

ESR1 has several biochemical functions, for example, ATPase binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ESR1 itself. We selected most functions ESR1 had, and list some proteins which have the same functions with ESR1. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingSYVN1;ALDOB;ANK2;BBC3;ATP6V1G1;GRIN2A;PKD2;CHMP4A;ESR1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingNEUROG3;PLAG1;MYBL1;ATF7;LEF1;HNRNPK;NCOA2;EN1;RFX1A
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA bindingESR2B;ESR1;ESR2A
beta-catenin bindingNF2;PROP1;HDAC6;TCF7;SLC9A3R1;CDH24;BCL9;CHD8;CBY1
chromatin bindingHDGF2;NCAPD2;SMAD6;ASH1L;MTA3;MEN1;GATA3;UBTFL;HMG20B
core promoter sequence-specific DNA bindingNR1D1;MEOX1;GATA3;ATF4;REST;PRMT5;CREM;NRIP1;NR4A3
enzyme bindingZFP36;LAMP1;PLCE1;BIRC5;DAOA;SELS;CASP2;GSTM2;UGT1A3
estrogen receptor activityESR2;ESR1;NKX3;GPR30;ESR2B;ESR2A;NKX3-1;LEF1
estrogen response element bindingTOX3;TRIM24;ESR1;ESR2
identical protein bindingCLDN9;IIGP1;MRAP2;CLDN16;CEP72;IK;CCDC91;PRNP;FHL2
nitric-oxide synthase regulator activityESR1;AKT1;CALM3;HSP90AA1.1;CALM2;HSP90AB1;HSP90AA1;CALM1
protein bindingTLR13;ABHD16A;TDO2;E2F8;MAP2K5;TNFSF13B;NUAK1;MTMR7;CARD10
steroid bindingESR2A;UGT1A1;HSD3B4;PAQR8;PGRMC2;NR3C1;NR3C2;ESRRGA;PAQR5A
steroid hormone receptor activityESRRB;RARA;VDRB;NR1H2;VDR;PPARDB;RORC;NR1H3;GPR30
transcription factor activity, sequence-specific DNA bindingEVX1;SLC25A46;FOSL2;BARX1;HOXC6B;CBL;ZFP354C;EGR2;ZC3H8
transcription factor bindingHEY2;BCL2;CEBPA;TFDP1A;IGHMBP2;HEYL;PBX1;ZBTB49;JUNB
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingSREBF1;HNRNPK;MIXL1;SIX4;TXK;ETV1;DBP;WT1;ONECUT1
zinc ion bindingRFWD3;RABGEF1L;TAF2;ESR1;RNF169;TRIM29;ZSWIM1;FBXO30A;RORCA

ESR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ESR1.

NCOA1; DDX5

Yu, T; Zhou, ZC; et al. A novel anti-cancer agent, acetyltanshinone IIA, inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor. CANCER LETTERS 346:94-103(2014).
Pogue-Geile, KL; Kim, C; et al. Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1782-1788(2013).
  • Q&As
  • Reviews

Q&As (5)

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What are the clinical implications of ESR1 mutations in breast cancer? 04/13/2023

ESR1 mutations can lead to resistance to endocrine therapies in breast cancer patients, impacting treatment outcomes.

How does ESR1 testing impact the prognosis of breast cancer patients? 10/02/2022

ESR1 testing can provide important prognostic information by helping to predict the likelihood of a favorable response to hormone therapy.

How is ESR1 protein detected in clinical practice? 09/27/2021

ESR1 protein can be detected through various laboratory techniques, including immunohistochemistry (IHC) and immunoblotting.

Can ESR1 mutations be targeted in breast cancer treatment? 02/23/2021

Research is ongoing, and there are efforts to develop targeted therapies for ESR1-mutated breast cancer, but it's still an evolving field.

How is ESR1 status determined in breast cancer patients? 05/05/2019

ESR1 status is determined through the examination of tumor tissue samples, often using IHC or molecular testing.

Customer Reviews (3)

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Reviews
05/30/2021

    Its high specificity and robust activity make it an ideal candidate for investigating intricate molecular interactions and elucidating complex biological mechanisms.

    04/24/2019

      Tthe manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed. he manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed.

      12/08/2017

        With the ESR1 protein, I can confidently pursue my scientific objectives and overcome experimental obstacles, enabling me to make significant strides in my field of study.

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