Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

ETV6

  • Official Full Name

    ets variant 6

  • Overview

    This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]
  • Synonyms

    ETV6; ets variant 6; TEL; TEL/ABL; transcription factor ETV6; TEL1 oncogene; ETS-related protein Tel1; ETS translocation variant 6; ets variant gene 6 (TEL oncogene);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ETV6-3540H Recombinant Human ETV6 Protein, GST-tagged Wheat Germ GST
Human ETV6-6519HCL Recombinant Human ETV6 293 Cell Lysate HEK293 N/A
Human ETV6-1247HFL Recombinant Full Length Human ETV6 Protein, C-Flag-tagged Mammalian cells Flag
Human ETV6-4372HF Recombinant Full Length Human ETV6 Protein, GST-tagged In Vitro Cell Free System GST 452 amino acids
Human ETV6-874H-B Recombinant Human ETV6 Protein Pre-coupled Magnetic Beads HEK293
Human ETV6-861H Recombinant Human ETV6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ETV6-874H Recombinant Human ETV6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ETV6-5354M Recombinant Mouse ETV6 Protein Mammalian Cell His
Mouse ETV6-2884M Recombinant Mouse ETV6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ETV6-2884M-B Recombinant Mouse ETV6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Etv6-981M Recombinant Mouse Etv6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque ETV6-1512R Recombinant Rhesus monkey ETV6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ETV6-1337R-B Recombinant Rhesus Macaque ETV6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ETV6-1337R Recombinant Rhesus Macaque ETV6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ETV6-8526Z Recombinant Zebrafish ETV6 Mammalian Cell His
Zebrafish ETV6-9341Z Recombinant Zebrafish ETV6 Mammalian Cell His
Chicken ETV6-4254C Recombinant Chicken ETV6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ETV6 Related Articles
  • ETV6 Related Research Area

ETV6 involved in several pathways and played different roles in them. We selected most pathways ETV6 participated on our site, such as Dorso-ventral axis formation, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ETV6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Dorso-ventral axis formationKRAS;PPP1R2P9;PIWIL1;CPEB1A;ETV6;SOS1;NOTCH1A;PIWIL2;NOTCH4
Transcriptional misregulation in cancerBCL2L1;PAX7;KLF3;HHEX;PROM1;HIST1H3H;FLT3;IGF1R;NCOR1

ETV6 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETV6 itself. We selected most functions ETV6 had, and list some proteins which have the same functions with ETV6. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingE2F8;RFX3;ZNF680;NCOA2;EP300;JDP2;ESR1;GCFC2;ELF4
RNA polymerase II regulatory region sequence-specific DNA bindingBHLHA15;SP1;E2F7;GATA2B;MNT;ZNF79;FERD3L;GATA5;NR1I2
RNA polymerase II transcription factor activity, sequence-specific DNA bindingSOX8;FOXD5;RUNX2;FOXD4L1;SPDEF;ETV4;FOXA;SIM1;TFAP2A
protein bindingFBXO32;UTP14A;SNRPD2;ATXN7;MUL1;SYTL2;PPARD;LRRC7;SCYL1
protein domain specific bindingERCC1;ATP1A1;ARHGEF4;CA;HNRNPM;CNOT1;SKI;RAN;STXBP1
transcription factor activity, sequence-specific DNA bindingZNF606;HOXB8B;E4F1;SP1;ZNF567;MYT1LA;RBPJA;NKX2-1;POU6F1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingSOX11;SOX4;ESR1;CEBPB;DLX3;STK16;EBF2;HEYL;HOXA7
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific bindingZC3H8;ZEB1;ARID5B;NFKB1;ETV7;CHCHD3;ESX1;JARID2;ETV6

ETV6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETV6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETV6.

WDYHV1; AP1M1; HDAC9; HDAC9; HDAC9; HDAC9; UBE2I; q81la6_bacan; fldB; MYC; SNW1; VPS26B; USP7

Manda, SS; Nirujogi, RS; et al. Identification and Characterization of Proteins Encoded by Chromosome 12 as Part of Chromosome-centric Human Proteome Project. JOURNAL OF PROTEOME RESEARCH 13:3166-3177(2014).
Linka, Y; Ginzel, S; et al. The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods. BLOOD CANCER JOURNAL 3:-(2013).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All ETV6 Products

Required fields are marked with *

My Review for All ETV6 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends