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FAN1

  • Official Full Name

    FANCD2/FANCI-associated nuclease 1

  • Overview

    Myotubularin related protein 15 (MTMR15) bears a coiled-coil and Rad18-type zinc finger domain. The function of MTMR15 remains uncharacterized; but it may play a role in DNA repair. Alternative names for MTMR15 include coiled-coil domain-containing protei
  • Synonyms

    FAN1; FANCD2/FANCI-associated nuclease 1; KIAA1018 , MTMR15, myotubularin related protein 15; fanconi-associated nuclease 1; myotubularin related protein 15; myotubularin-related protein 15; fanconi anemia associated nuclease 1; coiled-coil domain-contai;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FAN1-911HCL Recombinant Human FAN1 cell lysate N/A
Mouse FAN1-5666M Recombinant Mouse FAN1 Protein Mammalian Cell His
Mouse FAN1-3109M Recombinant Mouse FAN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FAN1-3109M-B Recombinant Mouse FAN1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish FAN1-4133Z Recombinant Zebrafish FAN1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FAN1 Related Articles

FAN1 involved in several pathways and played different roles in them. We selected most pathways FAN1 participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fanconi anemia pathwayHES1;CDK5R2;BRCA2;ERCC4;FANCA;C19orf40;HER6;MLH1;WDR48

FAN1 has several biochemical functions, for example, 5-3 exonuclease activity, 5-flap endonuclease activity, flap-structured DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAN1 itself. We selected most functions FAN1 had, and list some proteins which have the same functions with FAN1. You can find most of the proteins on our site.

Function Related Protein
5-3 exonuclease activityXRN2;DCLRE1C;FAN1;POLN;FEN1;EXO1;DOM3Z;CPSF3;DXO
5-flap endonuclease activitySLX1B;DNA2;FAN1;FEN1
flap-structured DNA binding
magnesium ion bindingNT5C1B;ENO2;DUT;PTENA;FOXK2;PRPS1B;NT5C1BA;MAP2K7;CDC42BPG
phosphodiesterase I activityFAN1;ENPP1;APEX1;ENPP2
protein bindingCTSZ;NGFR;PCDH18B;PCDHA4;SRSF10;FAM3C;SIM1;ZNF614;ZC3H14
ubiquitin bindingFAM125A;DNAJC2;UBXN2B;IDE;TOP2A;TSG101;CXCR4;USP16;PARK2

FAN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FAN1.

b4dt77_human; PPP2R1A; PIK3C2B; PSMD11; SUPT5H; AKR7A2; AP2A2; SDPR; HEXA; MLH1; PMS1; PMS2; HIST1H3D; TRAP1; PRPF4B; FSCN1; ANKLE2; WDR75; MIER1

Yan, PX; Huo, YG; et al. Crystal structure of human Fanconi-associated nuclease 1. PROTEIN & CELL 6:225-228(2015).
Zhao, Q; Xue, XY; et al. Structural insights into 5 ' flap DNA unwinding and incision by the human FAN1 dimer. NATURE COMMUNICATIONS 5:-(2014).
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