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FARS2

  • Official Full Name

    phenylalanyl-tRNA synthetase 2, mitochondrial

  • Overview

    Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.
  • Synonyms

    FARS2; phenylalanyl-tRNA synthetase 2, mitochondrial; FARS1, phenylalanine tRNA synthetase 1 (mitochondrial); phenylalanyl-tRNA synthetase, mitochondrial; dJ236A3.1; phenylalanine tRNA ligase 2; mitochondrial; dJ236A3.1 (phenylalanine tRNA synthetase); dJ520B18.2 (FARS1 (phenylalanine tRNA synthetase)); FARS1; HSPC320; Phenylalanine translase; Phenylalanine tRNA ligase 2, mitochondrial; Phenylalanine tRNA ligase; Phenylalanine tRNA synthetase 1 (mitochondrial); Phenylalanine tRNA synthetase 2 (mitochondrial); Phenylalanine--tRNA ligase; Phenylalanyl tRNA synthetase 2; PheRS; SYFM_HUMAN; OTTHUMP00000015986; dJ236A3.1 (phenylalanine-tRNA synthetase); phenylalanine-tRNA synthetase 1 (mitochondrial); phenylal; dJ520B18.2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FARS2-12748H Recombinant Human FARS2, GST-tagged E.coli GST 109-451a.a.
Human FARS2-3844H Recombinant Human FARS2 Protein, GST-tagged Wheat Germ GST
Human FARS2-8210H Recombinant Human FARS2 protein, His & T7-tagged E.coli His/T7 Met1~Phe451 (Accession # O95363)
Human FARS2-976H Recombinant Human Phenylalanyl-tRNA Synthetase 2, His-tagged E.coli His
Human FARS2-28164TH Recombinant Human FARS2, His-tagged E.coli His 415 amino acids
Human FARS2-6327HCL Recombinant Human FARS2 293 Cell Lysate HEK293 N/A
Human FARS2-3439H Recombinant Human FARS2 Protein (Met1-Phe451), N-His tagged E.coli N-His Met1-Phe451
Human FARS2-4758HF Recombinant Full Length Human FARS2 Protein, GST-tagged In Vitro Cell Free System GST 451 amino acids
Mouse Fars2-8211M Recombinant Mouse Fars2 protein, His & T7-tagged E.coli His/T7 Met1~Phe451 (Accession # Q99M01)
Mouse Fars2-2955M Recombinant Mouse Fars2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Fars2-8212R Recombinant Rat Fars2 protein, His & T7-tagged E.coli His/T7 Met1~Phe472 (Accession # Q6AYQ3)
Rat FARS2-2272R Recombinant Rat FARS2 Protein Mammalian Cell His
Rat FARS2-1929R Recombinant Rat FARS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FARS2-1929R-B Recombinant Rat FARS2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish FARS2-6014Z Recombinant Zebrafish FARS2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FARS2 Related Articles

FARS2 involved in several pathways and played different roles in them. We selected most pathways FARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, Gene Expression, Mitochondrial tRNA aminoacylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aminoacyl-tRNA biosynthesisMADD;PARS2;IARS2;LARS2;AARS2;TARSL2;FARSB;SARS;MARS
Gene ExpressionTSEN15;HNRNPH1;RBM5;CSTF1;SUZ12B;APOBEC1;ZNF480;ZNF443;PAIP1
Mitochondrial tRNA aminoacylationWARS2;KARS;FARS2;EARS2
tRNA AminoacylationDARS;FARSB;EEF1E1;EARS2;FARS2;AIMP2;WARS2;KARS;MADD

FARS2 has several biochemical functions, for example, ATP binding, magnesium ion binding, phenylalanine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FARS2 itself. We selected most functions FARS2 had, and list some proteins which have the same functions with FARS2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingOAS1;SUPV3L1;ANKK1;DDX46;MAST4;RTCD1;KCNJ1;LMTK2;ABL1
magnesium ion bindingTSSK3;RPS6KA3A;MAST4;ADPRHL1;PRPS1L1;TSSK4;GLUL;ALPP;PKM2
phenylalanine-tRNA ligase activityFARSB;FARS2;FDXACB1;FARSA
protein bindingFSTL5;GAB3;GNAI1;KIF27;YAF2;GAGE8;CAML;CORO1C;FZD5
tRNA bindingKARS;CTU2;CTU1;PTCD1;RARS;FDXACB1;MARS;ALKBH8;TRMT11

FARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FARS2.

KRT13; TADA2A; STX11; RCBTB2; TRIM27; KRTAP10-5

Klipcan, L; Moor, N; et al. Crystal Structure of Human Mitochondrial PheRS Complexed with tRNA(Phe) in the Active "Open" State. JOURNAL OF MOLECULAR BIOLOGY 415:527-537(2012).
Finarov, I; Moor, N; et al. Structure of Human Cytosolic Phenylalanyl-tRNA Synthetase: Evidence for Kingdom-Specific Design of the Active Sites and tRNA Binding Patterns. STRUCTURE 18:343-353(2010).
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