fars2
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  • Official Full Name
  • phenylalanyl-tRNA synthetase 2, mitochondrial
  • Background
  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.
  • Synonyms
  • FARS2; phenylalanyl-tRNA synthetase 2, mitochondrial; FARS1, phenylalanine tRNA synthetase 1 (mitochondrial); phenylalanyl-tRNA synthetase, mitochondrial; dJ236A3.1; phenylalanine tRNA ligase 2; mitochondrial; dJ236A3.1 (phenylalanine tRNA synthetase); dJ520B18.2 (FARS1 (phenylalanine tRNA synthetase)); FARS1; HSPC320; Phenylalanine translase; Phenylalanine tRNA ligase 2, mitochondrial; Phenylalanine tRNA ligase; Phenylalanine tRNA synthetase 1 (mitochondrial); Phenylalanine tRNA synthetase 2 (mitochondrial); Phenylalanine--tRNA ligase; Phenylalanyl tRNA synthetase 2; PheRS; SYFM_HUMAN; OTTHUMP00000015986; dJ236A3.1 (phenylalanine-tRNA synthetase); phenylalanine-tRNA synthetase 1 (mitochondrial); phenylal; dJ520B18.2
Cat.#:FARS2-3844HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FARS2 Protein, GST-tagged
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Cat.#:FARS2-976HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Phenylalanyl-tRNA Synthetase 2, His-tagged
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Cat.#:FARS2-12748HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FARS2, GST-tagged
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Cat.#:FARS2-28164THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FARS2, His-tagged
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Cat.#:FARS2-8210HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FARS2 protein, His & T7-tagged
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Cat.#:Fars2-8211MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fars2 protein, His & T7-tagged
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Cat.#:FARS2-2272RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FARS2 Protein
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Cat.#:Fars2-8212RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fars2 protein, His & T7-tagged
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Cat.#:FARS2-6014ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FARS2
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Cat.#:FARS2-6327HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FARS2 293 Cell Lysate
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Involved Pathway

FARS2 involved in several pathways and played different roles in them. We selected most pathways FARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, Gene Expression, Mitochondrial tRNA aminoacylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aminoacyl-tRNA biosynthesis
CARS; WARS2; FARS2; RARS; SARS; SEPSECS; RARS2; NARS2; TARS; PSTK
Gene Expression
C14orf166; CLNS1A; ZNF548; CCAR1; ZNF613; ZFP28; ZNF100; NR2E3; IGF2BP2; SKIB
Mitochondrial tRNA aminoacylation
WARS2; FARS2; EARS2; KARS
tRNA Aminoacylation
DARS; EARS2; KARS; EEF1E1; MADD; AIMP1; FARSB; WARS2; FARS2; AIMP2

Protein Function

FARS2 has several biochemical functions, for example, ATP binding, magnesium ion binding, phenylalanine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FARS2 itself. We selected most functions FARS2 had, and list some proteins which have the same functions with FARS2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DCK; SGK1; PIP4K2C; ADCY9; ATP2B1A; ALPK2; UBE2R2; ACSM2B; GRK1; PIP4K2A
Function magnesium ion binding
Related Protein MAP3K5; NT5C1B; IDH1; PGM3; GLUL; RPS6KA2; BPNT1; RPS6KA3B; PPM1NB; ATP9A
Function phenylalanine-tRNA ligase activity
Related Protein FARS2; FARSB; FARSA; FDXACB1
Function protein binding
Related Protein LAMA4; MAPKBP1; FBXO44; NR1D1; RWDD2B; RPSA; ACOT8; NR4A2; ABL2; SLC1A1
Function tRNA binding
Related Protein MARS; TRMT1L; TRMT1; TRMT11; XPO5; IGHMBP2; AIMP1; KARS; SSB; FDXACB1

Interacting Protein

FARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FARS2.
KRT13; TADA2A; STX11; RCBTB2; TRIM27; KRTAP10-5

FARS2 Related Articles

Klipcan, L; Moor, N; et al. Crystal Structure of Human Mitochondrial PheRS Complexed with tRNA(Phe) in the Active "Open" State. JOURNAL OF MOLECULAR BIOLOGY 415:527-537(2012).
Finarov, I; Moor, N; et al. Structure of Human Cytosolic Phenylalanyl-tRNA Synthetase: Evidence for Kingdom-Specific Design of the Active Sites and tRNA Binding Patterns. STRUCTURE 18:343-353(2010).