Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

FBXL7

Official Full Name

F-box and leucine-rich repeat protein 7
Overview

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats.
Synonyms

FBXL7; F-box and leucine-rich repeat protein 7; F-box/LRR-repeat protein 7; FBL6; FBL7; KIAA0840; F-box protein Fbl7; F-box protein FBL6/FBL7;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FBXL7-3910H	Recombinant Human FBXL7 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FBXL7-273HCL	Recombinant Human FBXL7 lysate	HEK293	N/A		Inquiry
Human	FBXL7-5005HF	Recombinant Full Length Human FBXL7 Protein, GST-tagged	In Vitro Cell Free System	GST	491 amino acids	Inquiry
Mouse	FBXL7-5727M	Recombinant Mouse FBXL7 Protein	Mammalian Cell	His		Inquiry
Mouse	FBXL7-3151M	Recombinant Mouse FBXL7 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	FBXL7-3151M-B	Recombinant Mouse FBXL7 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	FBXL7-1656R	Recombinant Rhesus monkey FBXL7 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	FBXL7-1480R	Recombinant Rhesus Macaque FBXL7 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	FBXL7-1480R-B	Recombinant Rhesus Macaque FBXL7 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
FBXL7 Related Articles

FBXL7 involved in several pathways and played different roles in them. We selected most pathways FBXL7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

FBXL7 has several biochemical functions, for example, contributes_to ubiquitin protein ligase activity, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL7 itself. We selected most functions FBXL7 had, and list some proteins which have the same functions with FBXL7. You can find most of the proteins on our site.

Function	Related Protein
contributes_to ubiquitin protein ligase activity	MED11;CUL2;FBXL4;FBXL12;FBXL3A;FBXL3B;FBXL17;CUL4A;FBXL3
ubiquitin-protein transferase activity	RNF144AB;ITCH;WDSUB1;FEM1B;PDZRN3B;BTR22;FBXO7;FANCL;RNF20

FBXL7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL7.

b4dyc6_human; SKP1; NUDCD2; NUDC; ggt

Liu, Y; Lear, T; et al. F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. CELL DEATH & DISEASE 6:-(2015).

Rodrigues-Campos, M; Thompson, BJ; et al. The ubiquitin ligase FbxL7 regulates the Dachsous-Fat-Dachs system in Drosophila. DEVELOPMENT 141:4098-4103(2014).